The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Kallikrein‐mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin
Abstract
The presence of cathelicidin antimicrobial peptides provides an important mechanism for prevention of infection against a wide variety of microbial pathogens. The activity of cathelicidin is controlled by enzymatic processing of the proform (hCAP18 in humans) to a mature peptide (LL‐37 in human neutrophils). In this study, elements important to the processing of cathelicidin in the skin were examined. Unique cathelicidin peptides distinct from LL‐37 were identified in normal skin. Through the use of selective inhibitors, SELDI‐TOF‐MS, Western blot, and siRNA, the serine proteases stratum corneum tryptic enzyme (SCTE, kallikrein 5) and stratum corneum chymotryptic protease (SCCE, kallikrein 7) were shown to control activation of the human cathelicidin precursor protein hCAP18 and also influence further processing to smaller peptides with alternate biological activity. The importance of this serine protease activity to antimicrobial activity in vivo was illustrated in SPINK5 ‐deficent mice that lack the serine protease inhibitor LEKTI. Epidermal extracts of these animals show a significant increase in antimicrobial activity compared with controls, and immunoabsorption of cathelicidin diminished antimicrobial activity. These observations demonstrate that the balance of proteolytic activity at an epithelial interface will control innate immune defense.—Yamasaki, K., Schauber, J., Coda, A., Lin, H., Dorschner, R. A., Schechter, N. M., Bonnart, C., Descargues, P., Hovnanian, A., Gallo, R. L. Kallikrein‐mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. FASEB J. 20, 2068–2080 (2006)
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Cites
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citationCutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression
Wang, T.-T., Nestel, F. P., Bourdeau, V., Nagai, Y., Wang, Q., Liao, J., Tavera-Mendoza, L., Lin, R., Hanrahan, J. W., Mader, S., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.2909 · Cited by 1,637
Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J. M., Wooters, J., Oppenheim, J. J., & Chertov, O. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1069 · Cited by 1,240
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citationCathelicidins, multifunctional peptides of the innate immunity
Zanetti, M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0403147 · Cited by 988
Sørensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., & Borregaard, N. (2001) · Blood · doi:10.1182/blood.v97.12.3951 · Cited by 894
An angiogenic role for the human peptide antibiotic LL-37/hCAP-18
Koczulla, R., von Degenfeld, G., Kupatt, C., Krötz, F., Zahler, S., Gloe, T., Issbrücker, K., Unterberger, P., Zaiou, M., Lebherz, C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17545 · Cited by 863
Self-citationMutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
Chavanas, S., Bodemer, C., Rochat, A., Hamel-Teillac, D., Ali, M., Irvine, A. D., Bonafé, J.-L., Wilkinson, J., Taïeb, A., Barrandon, Y., et al. (2000) · Nature Genetics · doi:10.1038/75977 · Cited by 856
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Alarmins: chemotactic activators of immune responses
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Cited by
Wang, G., Mishra, B., Epand, R. F., & Epand, R. M. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.01.016 · Cited by 184
Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem
Chen, H., Zhao, Q., Zhong, Q., Duan, C., Krutmann, J., Wang, J., & Xia, J. (2022) · Phenomics · doi:10.1007/s43657-022-00073-y · Cited by 79
Metadata
- Authors
- Yamasaki, K., Schauber, J., Coda, A., Lin, H., Dorschner, R. A., Schechter, N. M., Bonnart, C., Descargues, P., Hovnanian, A., & Gallo, R. L.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2006-10
- Volume
- 20
- Issue
- 12
- Pages
- 2068-2080
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1979258089
- Cited by
- 462
- References
- 50
- FWCI
- 17.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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