Cited by 826Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

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Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

Junttila, Melissa R., Li, Song‐Ping, Westermarck, Jukka·2008·The FASEB Journal

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Abstract

Mitogen-activated protein kinase (MAPK) pathways constitute a large modular network that regulates a variety of physiological processes, such as cell growth, differentiation, and apoptotic cell death. The function of the ERK pathway has been depicted as survival-promoting, in essence by opposing the proapoptotic activity of the stress-activated c-Jun NH(2)-terminal kinase (JNK)/p38 MAPK pathways. However, recently published work suggests that extracellular regulated kinase (ERK) pathway activity is suppressed by JNK/p38 kinases during apoptosis induction. In this review, we will summarize the current knowledge about JNK/p38-mediated mechanisms that negatively regulate the ERK pathway. In particular, we will focus on phosphatases (PP2A, MKPs) as inhibitors of ERK pathway activity in regulating apoptosis. A model proposed in this review places the negative regulation of the ERK pathway in a central position for the cellular decision-making process that determines whether cells will live or die in response to apoptosis-promoting signals. In addition, we will discuss the potential functional relevance of negative regulation of ERK pathway activity, for physiological and pathological conditions (e.g., cellular transformation).

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Authors: Junttila, M. R., Li, S., & Westermarck, J.
Affiliations: Åbo Akademi University (FI)
University of Helsinki (FI)
ORCID: Junttila, Melissa R.
Westermarck, Jukka
Venue: The FASEB Journal
Publisher: Wiley
Published: 2007-11-26
Volume: 22
Issue: 4
Pages: 954-965
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.06-7859rev
OpenAlex: W2003060606
Cited by: 826
References: 138
Citations by year: 2026: 12 · 2025: 21 · 2024: 24 · 2023: 19 · 2022: 32 · 2021: 48 · 2020: 28 · 2019: 36 · 2018: 42 · 2017: 41 · 2016: 58 · 2015: 49 · 2014: 76 · 2013: 72 · 2012: 74
FWCI: 3.08
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: ERK signaling, phosphatase, protein phosphatase 2A, apoptosis, cell survival
MeSH terms: Animals, Cell Survival, Humans, Models, Biological, Phosphoprotein Phosphatases, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

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Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

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