Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961 · cited 1×

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

Hunter, T. R. (1995) · Cell · doi:10.1016/0092-8674(95)90405-0 · Cited by 2,961

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Roberts, P. J., & Der, C. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210422 · Cited by 2,788

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

Roux, P. P., & Blenis, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.2.320-344.2004 · Cited by 2,540

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

Bengtsson, L., Schwappacher, R., Roth, M., Boergermann, J. H., Haßel, S., & Knaus, P. I. (2009) · Journal of Cell Science · doi:10.1242/jcs.039552 · Cited by 52

The inhibition of TNF ‐α‐induced leucocyte apoptosis by melatonin involves membrane receptor MT 1/ MT 2 interaction

Espino, J., Rodríguez, A. B., & Pariente, J. A. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12042 · Cited by 51

Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance

Olsen, C. E., Weyergang, A., Edwards, V. T., Berg, K., Brech, A., Weisheit, S., Høgset, A., & Selbo, P. K. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.08.002 · Cited by 51

Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

Zeng, Q., Zhang, H., Qin, J., Xu, Z., Gui, L., Liu, B., Liu, C., Xu, C., Liu, W., Zhang, S., et al. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1976-1 · Cited by 52

T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of MKP1 Protein Prevents Solar Ultraviolet Light-induced Inflammation through Inhibition of the p38 Protein Signaling Pathway

Li, S., Zhu, F., Zykova, T. A., Kim, M. O., Cho, Y. Y., Bode, A. M., Peng, C., Ma, W., Carper, A., Langfald, A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.225813 · Cited by 51

Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I

Watson, C. S., Jeng, Y., Hu, G., Wozniak, A. L., Bulayeva, N. N., & Guptarak, J. (2011) · Steroids · doi:10.1016/j.steroids.2011.12.025 · Cited by 50

rhPDGF-BB Via ERK Pathway Osteogenesis and Adipogenesis Balancing in ADSCs for Critical-Sized Calvarial Defect Repair

Jin, Y., Zhang, W., Liu, Y., Zhang, M., Xu, L., Wu, Q., Zhang, X., Zhu, Z., Huang, Q., & Jiang, X. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0556 · Cited by 50

Ceramide-dependent PP2A regulation of TNFα-induced IL-8 production in respiratory epithelial cells

Cornell, T. T., Hinkovska‐Galcheva, V., Sun, L., Cai, Q., Hershenson, M. B., VanWay, S. M., & Shanley, T. P. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90516.2008 · Cited by 50

Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease

Jiang, Q., Chen, S., Hu, C., Huang, P., Shen, H., & Zhao, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5542 · Cited by 50

The breast cancer stem cell potency of copper( ii ) complexes bearing nonsteroidal anti-inflammatory drugs and their encapsulation using polymeric nanoparticles

Eskandari, A., Boodram, J. N., Cressey, P., Lü, C., Bruno, P. M., Hemann, M. T., & Suntharalingam, K. (2016) · Dalton Transactions · doi:10.1039/c6dt03811e · Cited by 50

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models

Chiacchiera, F., Grossi, V., Cappellari, M., Peserico, A., Simonatto, M., Germani, A., Russo, S., Moyer, M. P., Resta, N., Murzilli, S., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.05.006 · Cited by 50

Modulation of viability and apoptosis of UVB-exposed human keratinocyte HaCaT cells by aqueous methanol extract of laver (Porphyra yezoensis)

Kim, S., You, D. H., Han, T., & Choi, E.-M. (2014) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2014.10.012 · Cited by 49

Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis

Zaidan, I., Tavares, L. P., Sugimoto, M. A., Lima, K. M., Negreiros-Lima, G. L., Teixeira, L. C. R., Miranda, T. C., Valiate, B. V. S., Cramer, A. T., Vago, J. P., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.147819 · Cited by 50

Ribose‐5‐phosphate isomerase A regulates hepatocarcinogenesis via PP2A and ERK signaling

Ciou, S., Chou, Y., Liu, Y., Nieh, Y., Lu, J., Huang, S.-F. K., Chou, Y., Cheng, L., Lo, J., Chen, M., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29361 · Cited by 53

S100A16 promotes cell proliferation and metastasis via AKT and ERK cell signaling pathways in human prostate cancer

Zhu, W., Xue, Y., Liang, C., Zhang, R., Zhang, Z., Li, H., Su, D., Liang, X., Zhang, Y., Huang, Q., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-5096-9 · Cited by 49

Upregulation of the oncoprotein SET determines poor clinical outcomes in hepatocellular carcinoma and shows therapeutic potential

Hung, M.-H., Chen, Y.-L., Chu, P.-Y., Shih, C.-T., Yu, H.-C., Tai, W.-T., Shiau, C.-W., & Chen, K.-F. (2016) · Oncogene · doi:10.1038/onc.2016.21 · Cited by 48

Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development

Beier, A., Teichert, I., Krisp, C., Wolters, D. A., & Kück, U. (2016) · mBio · doi:10.1128/mbio.00870-16 · Cited by 51

Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells

Rahman, M. M., Rumzhum, N. N., Hansbro, P. M., Morris, J. C., Clark, A. R., Verrills, N. M., & Ammit, A. J. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.01.009 · Cited by 48

Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression

Gao, J., Ulekleiv, C. H., & Halstensen, T. S. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0422-z · Cited by 48

Breast Cancer Stem Cell Potent Copper(II)–Non‐Steroidal Anti‐Inflammatory Drug Complexes

Boodram, J. N., Mcgregor, I. J., Bruno, P. M., Cressey, P., Hemann, M. T., & Suntharalingam, K. (2016) · Angewandte Chemie · doi:10.1002/ange.201510443 · Cited by 48

Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

Dessauges, C., Mikelson, J., Dobrzyński, M., Jacques, M., Frismantiene, A., Gagliardi, P. A., Khammash, M., & Pertz, O. (2022) · Molecular Systems Biology · doi:10.15252/msb.202110670 · Cited by 48

Synthetic Phosphorylation of p38α Recapitulates Protein Kinase Activity

Chooi, K. P., Galan, S. R. G., Raj, R., McCullagh, J., Mohammed, S., Jones, L. H., & Davis, B. G. (2014) · Journal of the American Chemical Society · doi:10.1021/ja4095318 · Cited by 47

Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma

Yu, H.-C., Chen, H.-J., Chang, Y.-L., Liu, C., Shiau, C., Cheng, A., & Chen, K. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.009 · Cited by 47

CD24 enhances DNA damage-induced apoptosis by modulating NF-κB signaling in CD44-expressing breast cancer cells

Ju, J.-H., Jang, K., Lee, K., Kim, M., Kim, J., Yi, J. Y., Noh, D., & Shin, I. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr173 · Cited by 50

Substance P stimulates the recovery of bone marrow after the irradiation

An, Y. S., Lee, E., Kang, M., Hong, H. S., Kim, M., Jang, W. S., Son, Y., & Yi, J. Y. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22447 · Cited by 47

Leptin regulates disc cartilage endplate degeneration and ossification through activation of the MAPK‐ERK signalling pathway in vivo and in vitro

Han, Y., Ma, B., Guo, S., Yang, M., Li, L., Wang, S., & Tan, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13398 · Cited by 51

Cadmium induces apoptosis in primary rat osteoblasts through caspase and mitogen-activated protein kinase pathways

Zhao, H., Liu, W., Wang, Y., Dai, N., Gu, J., Yuan, Y., Liu, X., Bian, J., & Liu, Z. (2015) · Journal of Veterinary Science · doi:10.4142/jvs.2015.16.3.297 · Cited by 47

Correction: Integrative Modelling of the Influence of MAPK Network on Cancer Cell Fate Decision

Grieco, L., Calzone, L., Bernard‐Pierrot, I., Radvanyi, F., Kahn‐Perlès, B., & Thieffry, D. (2013) · PLoS Computational Biology · doi:10.1371/annotation/90e5e4be-952b-42b8-b56d-46baae3479ed · Cited by 47

Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures

Lü, Q., Rau, T. F., Harris, V. K., Johnson, M. H., Poulsen, D. J., & Black, S. M. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07786.x · Cited by 46

Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome

Yu, H.-C., Hou, D., Liu, C., Lin, C., Shiau, C., Cheng, A., & Chen, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055705 · Cited by 46

Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation

Liu, H., Xiao, Y., Xiong, C., Wei, A., & Ruan, J. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.036 · Cited by 46

Role of the p38 pathway in mineral trioxide aggregate‐induced cell viability and angiogenesis‐related proteins of dental pulp cell in vitro

Huang, S., Wu, B.-C., Kao, C. ‐., Huang, T., Hung, C. ‐., & Shie, M. (2014) · International Endodontic Journal · doi:10.1111/iej.12305 · Cited by 46

Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently

Choy, K. W., Lau, Y. S., Murugan, D. D., Vanhoutte, P. M., & Mustafa, M. R. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245217 · Cited by 46

Reactive oxygen species regulate prosurvival ERK1/2 signaling and bFGF expression in gliosis within the retina

Groeger, G., Doonan, F., Cotter, T. G., & Donovan, M. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-10525 · Cited by 45

Role and interaction of p53, BAX and the stress-activated protein kinases p38 and JNK in benzo(a)pyrene-diolepoxide induced apoptosis in human colon carcinoma cells

Donauer, J., Schreck, I., Liebel, U., & Weiß, C. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0757-3 · Cited by 45

Astragaloside IV Alleviates Lipopolysaccharide-Induced Acute Kidney Injury Through Down-Regulating Cytokines, CCR5 and p-ERK, and Elevating Anti-Oxidative Ability

Zhou, W., Chen, Y., & Zhang, X. (2017) · Medical Science Monitor · doi:10.12659/msm.899618 · Cited by 45

Chiral geometry regulates stem cell fate and activity

Dong, L., Gong, J., Wang, Y., He, J., You, D., Zhou, Y., Li, Q., Liu, Y., Cheng, K., Qian, J. W., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119456 · Cited by 48

Heat-shock protein 90 alpha (HSP90α) modulates signaling pathways towards tolerance of oxidative stress and enhanced survival of hepatocytes of Mugil cephalus

Padmini, E., & Rani, M. U. (2011) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0255-9 · Cited by 44

ABCC6 as a Target in Pseudoxanthoma Elasticum

Váradi, A., Szabó, Z., Pomozi, V., de Boussac, H., Fülöp, K., & Arányi, T. (2011) · Current Drug Targets · doi:10.2174/138945011795378612 · Cited by 47

Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells

Lee, Y.-M., Ting, C. M., Cheng, Y., Fan, T.-P., Wong, R. N., Lung, M. L., & Mak, N. K. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.010 · Cited by 44

Protective effects of Oviductus Ranae-containing serum on oxidative stress-induced apoptosis in rat ovarian granulosa cells

Ling, X.-M., Zhang, X.-H., Tan, Y. H., Yang, J., Ji, B., Wu, X., Yi, Y., & Liang, L. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.05.035 · Cited by 44

Cyclosporin A induces apoptosis in H9c2 cardiomyoblast cells through calcium-sensing receptor-mediated activation of the ERK MAPK and p38 MAPK pathways

Chi, J., Zhu, Y., Fu, Y., Liu, Y., Zhang, X., Han, L., Yin, X., & Zhao, D. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1336-5 · Cited by 43

Neuroprotection Mediated by P2Y 13 Nucleotide Receptors in Neurons

Pérez‐Sen, R., Queipo, M. J., Morente, V., Ortega, F., Delicado, E. G., & Miras‐Portugal, M. T. (2015) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2015.02.002 · Cited by 44

Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System

Peleteiro, M., Presas, E., González-Aramúndiz, J. V., Sánchez-Correa, B., Simón‐Vázquez, R., Csaba, N., Alonso, M. J., & González‐Fernández, Á. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00791 · Cited by 43

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response

Haigh, C. L., Drew, S. C., Boland, M. P., Masters, C. L., Barnham, K. J., Lawson, V., & Collins, S. J. (2009) · Journal of Cell Science · doi:10.1242/jcs.043604 · Cited by 43

Role of the P38 Pathway in Calcium Silicate Cement–induced Cell Viability and Angiogenesis-related Proteins of Human Dental Pulp Cell In Vitro

Chou, M., Kao, C., Hung, C.-J., Huang, T., Huang, S.-C., Shie, M., & Wu, B. (2013) · Journal of Endodontics · doi:10.1016/j.joen.2013.09.041 · Cited by 42

Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway

Han, R., Liang, H., Qin, Z., & Liu, C. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.62 · Cited by 42

Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades

Liu, J., Wang, B., Huang, P., Wang, H., Xu, K., Wang, X., Xu, L., & Guo, Z. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.08.002 · Cited by 43

Regulation of Signal Transduction by DJ-1

Oh, S. E., & Mouradian, M. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6583-5_8 · Cited by 44

Costunolide enhances doxorubicin-induced apoptosis in prostate cancer cells via activated mitogen-activated protein kinases and generation of reactive oxygen species

Chen, J., Chen, B., Zou, Z., Li, W., Zhang, Y., Xie, J., & Liu, C. (2017) · Oncotarget · doi:10.18632/oncotarget.22592 · Cited by 42

Role of iron and iron‐related proteins in mesenchymal stem cells: Cellular and clinical aspects

Mehta, K. J. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30383 · Cited by 43

17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway

Khan, I., Saeed, K. M., Jo, M. G., & Kim, M. O. (2021) · Antioxidants · doi:10.3390/antiox10060892 · Cited by 43

JNK Pathway Activation Is Controlled by Tao/TAOK3 to Modulate Ethanol Sensitivity

Kapfhamer, D., King, I. F. G., Zou, M. E., Lim, J. P., Heberlein, U., & Wolf, F. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050594 · Cited by 42

Metabolic benefits of inhibition of p38α in white adipose tissue in obesity

Zhang, S., Cao, H., Li, Y., Jing, Y., Liu, S., Cheng, Y., Wang, H., Yu, S., Peng, C., Hui, L., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2004225 · Cited by 41

ROS‐mediated p38α MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas‐mediated cell death in Taiwan cobra phospholipase A2‐treated U937 cells

Liu, W., Cheng, Y., & Chang, L. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21713 · Cited by 41

A systematic analysis of signaling reactivation and drug resistance

Kholodenko, B. Ν., Rauch, N., Kölch, W., & Rukhlenko, O. S. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109157 · Cited by 43

The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

Graça, F. A., Rai, M., Hunt, L. C., Stephan, A., Wang, Y., Gordon, B., Wang, R., Quarato, G., Xu, B., Fan, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30120-1 · Cited by 41

Microcystin-lr induces protein phosphatase 2a alteration in a human liver cell line

Sun, Y., Zheng, Q., Sun, Y.-T., Huang, P., Guo, Z., & Xu, L. (2013) · Environmental Toxicology · doi:10.1002/tox.21854 · Cited by 40

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

Huang, C., Zeng, X., Jiang, G., Liao, X., Li, J., Li, J., Jin, H., Zhu, J., Sun, H., Wu, X.-R., et al. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0376-9 · Cited by 40

Crosstalk and the evolvability of intracellular communication

Rowland, M. A., Greenbaum, J. M., & Deeds, E. J. (2017) · Nature Communications · doi:10.1038/ncomms16009 · Cited by 40

P2 receptor interaction and signalling cascades in neuroprotection

Miras‐Portugal, M. T., Queipo, M. J., Gil‐Redondo, J. C., Ortega, F., Gómez‐Villafuertes, R., Gualix, J., Delicado, E. G., & Pérez‐Sen, R. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.012 · Cited by 43

Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic β-cells

Guo, J., Qian, Y., Xi, X.-X., Hu, X., Zhu, J., & Han, X. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0362-4 · Cited by 40

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 3: PD-L1, Intracellular Signaling Pathways and Tumor Microenvironment

Palicelli, A., Croci, S., Bisagni, A., Zanetti, E., de Biase, D., Melli, B., Sanguedolce, F., Ragazzi, M., Zanelli, M., Chaux, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212330 · Cited by 41

Phosphatase-Dependent Regulation of Epithelial Mitogen-Activated Protein Kinase Responses to Toxin-Induced Membrane Pores

Aguilar, J. L., Kulkarni, R., Randis, T. M., Soman, S., Kikuchi, A., Yin, Y., & Ratner, A. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008076 · Cited by 39

Activated Microglia Are Less Vulnerable to Hemin Toxicity due to Nitric Oxide-Dependent Inhibition of JNK and p38 MAPK Activation

Cai, Y., Cho, G., Ju, C., Wang, S.-L., Ryu, J. H., Shin, C. Y., Kim, H.-S., Nam, K.-W., Jalin, A. M. A. A., Sun, W., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002925 · Cited by 39

The Protein Phosphatase 2A Regulatory Subunits B′β and B′δ Mediate Sustained TrkA Neurotrophin Receptor Autophosphorylation and Neuronal Differentiation

Kanegan, M. J. V., & Strack, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01242-08 · Cited by 42

MEK-independent ERK activation in human neutrophils and its impact on functional responses

Simard, F. A., Cloutier, A., Ear, T., Vardhan, H., & McDonald, P. P. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ma1214-599r · Cited by 38

Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathways

Park, J., KWON, J. K., Kim, H. R., Kim, H. J., KIM, B. S., & Jung, J. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1679 · Cited by 39

Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway

Gong, J., Shen, X., Chen, C., Qiu, H., & Yang, R. (2011) · Virologica Sinica · doi:10.1007/s12250-011-3184-y · Cited by 37

Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin

Rahman, M. M., Rumzhum, N. N., Morris, J. C., Clark, A. R., Verrills, N. M., & Ammit, A. J. (2015) · Scientific Reports · doi:10.1038/srep10063 · Cited by 38

Inhibition of Nickel Nanoparticles-Induced Toxicity by Epigallocatechin-3-Gallate in JB6 Cells May Be through Down-Regulation of the MAPK Signaling Pathways

Gu, Y., Wang, Y., Zhou, Q., Bowman, L. L., Mao, G., Zou, B., Xu, J., Liu, Y., Liu, K., Zhao, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150954 · Cited by 38

Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells

Kabeer, F. A., Rajalekshmi, D. S., Nair, M. S., & Remani, P. (2017) · Integrative Medicine Research · doi:10.1016/j.imr.2017.03.004 · Cited by 38

The role of dietary flavonoids for modulation of ATP binding cassette transporter mediated multidrug resistance

Teng, H., Deng, H., He, Y., Lv, Q., & Chen, L. (2021) · eFood · doi:10.53365/efood.k/144604 · Cited by 38

Hepatocyte Proliferation/Growth Arrest Balance in the Liver of Mice during E. multilocularis Infection: A Coordinated 3-Stage Course

Zhang, C., Wang, J., Lü, G., Li, J., Lu, X., Mantion, G., Vuitton, D. A., Wen, H., & Lin, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030127 · Cited by 40

Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway

Wang, G., Han, B., Zhou, H., Wu, L., Wang, Y., Jia, G., Lv, J., Cheng, Z., Pan, S., Liu, J., et al. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0770-x · Cited by 37

Genome-wide landscape of DNA methylomes and their relationship with mRNA and miRNA transcriptomes in oxidative and glycolytic skeletal muscles

Shen, L., Du, J., Xia, Y., Tan, Z., Fu, Y., Yang, Q., Li, X., Tang, G., Jiang, Y., Wang, J., et al. (2016) · Scientific Reports · doi:10.1038/srep32186 · Cited by 38

A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

Arriazu, E., Vicente, C., Pippa, R., Peris, I., Martínez‐Balsalobre, E., Ramírez, P. G., Marcotegui, N., Igea, A., Alignani, D., Rifón, J., et al. (2020) · Blood Cancer Journal · doi:10.1038/s41408-019-0270-0 · Cited by 35

Spred-2 Deficiency Exacerbates Lipopolysaccharide-Induced Acute Lung Inflammation in Mice

Xu, Y., Ito, T., Fushimi, S., Takahashi, S., Itakura, J., Kimura, R., Sato, M., Mino, M., Yoshimura, A., & Matsukawa, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108914 · Cited by 35

The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells

Rahman, M. M., Prünte, L., Lebender, L. F., Patel, B. S., Gelissen, I. C., Hansbro, P. M., Morris, J. C., Clark, A. R., Verrills, N. M., & Ammit, A. J. (2016) · Scientific Reports · doi:10.1038/srep37297 · Cited by 37

Enhanced Insulin Sensitivity Associated with Provision of Mono and Polyunsaturated Fatty Acids in Skeletal Muscle Cells Involves Counter Modulation of PP2A

Nardi, F., Lipina, C., Magill, D., Hage Hassan, R., Hajduch, E., Gray, A., & Hundal, H. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092255 · Cited by 36

Molecular dynamics of inflammation resolution: therapeutic implications

Soliman, A. M., Soliman, M. M., Shah, S. S. H., Baig, H. A., Gouda, N. S., Alenezi, B. T., Alenezy, A. K., Hegazy, A. M. S., Jan, M., & Abdalla, E. H. E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600149 · Cited by 39

ERK phosphorylation and miR-181a expression modulate activation of human memory TH17 cells

Mele, F., Basso, C., Leoni, C., Aschenbrenner, D., Becattini, S., Latorre, D., Lanzavecchia, A., Sallusto, F., & Monticelli, S. (2015) · Nature Communications · doi:10.1038/ncomms7431 · Cited by 36

Comparative Transcriptional Profiling of Two Contrasting Barley Genotypes under Salinity Stress during the Seedling Stage

Gao, R., Duan, K., Guo, G., ZhiZhao, D., Chen, Z., Li, L., He, T., Lu, R., & Huang, J. (2013) · International Journal of Genomics · doi:10.1155/2013/972852 · Cited by 36

Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance

Xie, L., Liu, C., Wang, L., Gunawardena, H. P., Yu, Y., Du, R., Taxman, D. J., Dai, P., Yan, Z., Yu, J., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.029 · Cited by 37

SETBP1dysregulation in congenital disorders and myeloid neoplasms

Coccaro, N., Tota, G., Zagaria, A., Anelli, L., Specchia, G., & Albano, F. (2017) · Oncotarget · doi:10.18632/oncotarget.17231 · Cited by 37

AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity

Liang, D., Tian, L. H., You, R., Halpert, M. M., Konduri, V., Baig, Y. C., Paust, S., Kim, D., Kim, S., Jia, F., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01801 · Cited by 35

Ononin Shows Anticancer Activity Against Laryngeal Cancer via the Inhibition of ERK/JNK/p38 Signaling Pathway

Ye, B., Ma, J., Li, Z., Li, Y., & Han, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.939646 · Cited by 37

Ribosome Synthesis and MAPK Activity Modulate Ionizing Radiation-Induced Germ Cell Apoptosis in Caenorhabditis elegans

Eberhard, R., Stergiou, L., Hofmann, E. R., Hofmann, J., Haenni, S., Teo, Y., Furger, A., & Hengartner, M. O. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003943 · Cited by 35

Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes

Sun, L. Y., Steinbaugh, M. J., Masternak, M. M., Bartke, A., & Miller, R. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.021 · Cited by 36

Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery

Morente, V., Pérez‐Sen, R., Ortega, F., Huerta‐Cepas, J., Delicado, E. G., & Miras‐Portugal, M. T. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.004 · Cited by 36

The Kidney Vero-E6 Cell Line: A Suitable Model to Study the Toxicity of Microcystins

Menezes, C., Valério, E., & Dias, E. M. (2013) · InTech eBooks · doi:10.5772/54463 · Cited by 36

Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay

Schulpen, S. H. W., Pennings, J. L. A., & Piersma, A. H. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv094 · Cited by 36

Targeted chemotherapy overcomes drug resistance in melanomaPreprint

Yue, J., Vendramin, R., Liu, F., Lopez, O., Valencia, M. G., Santos, H. G. D., Gaidosh, G., Beckedorff, F., Blumenthal, E., Speroni, L., et al. (2020) · Genes & Development · doi:10.1101/gad.333864.119 · Cited by 38

Upregulation of AKT Attenuates Amyloid-β-Induced Cell Apoptosis

Yin, G., Li, L., Qu, M., Luo, H., Wang, J., & Zhou, X. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110104 · Cited by 35

SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A

Hung, M., Wang, C., Chen, Y., Chu, P., Hsiao, Y., Tai, W., Chao, T.-T., Yu, H.-C., Shiau, C., & Chen, K. (2015) · Oncotarget · doi:10.18632/oncotarget.6313 · Cited by 35

Neuroprotection of N-benzylcinnamide on scopolamine-induced cholinergic dysfunction in human SH-SY5Y neuroblastoma cells

Thangnipon, W., Puangmalai, N., Soi‐ampornkul, R., Suwanna, N., Tuchinda, P., & Nobsathian, S. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.215262 · Cited by 35

Fabrication, characterization and in vitro evaluation of disulfiram-loaded cellulose acetate/poly(ethylene oxide) nanofiber scaffold for breast and colon cancer cell lines treatment

Fawal, G. F. E., Abu-Serie, M. M., El‐Gendi, H., & El‐Fakharany, E. M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.145 · Cited by 35

Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability

Frasca, D., Romero, M., Landin, A. M., Diaz, A., Riley, R. L., & Blomberg, B. B. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.02.002 · Cited by 35

The FASEB Journal • Review Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

Junttila, M. R., Li, S.-P., & Westermarck, J. (2014)

Signal transduction mediated by mitogen-activated protein kinases and apoptisis of tumor cells

Ji, Yubin, Y., Sun, Shengnan, Zou, Xiang, ■., antineoplastic, Harbin, on, Postdoctoral, et al. (2008) · Shenyang Yaoke Daxue xuebao

Mitogen-activated protein kinases in apoptosis regulation

Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

Fey, D., Croucher, D. R., Kölch, W., & Kholodenko, B. Ν. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00355 · Cited by 171