An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR‐1. Ac ‐APR‐1 from the dog hookworm, Ancylostoma caninum , protects dogs against hookworm infection via antibodies that neutralize enzymatic activity and interrupt blood‐feeding. Tow…