The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tlr2 is critical for diet‐induced metabolic syndrome in a murine model
Open accessAbstract
Obesity and its associated comorbidities, termed metabolic syndrome, are increasingly prevalent, and they pose a serious threat to the health of individuals and populations. Gene‐environment interactions have been scrutinized since the kinetics of the increased prevalence of obesity would argue against a purely genetic etiology. Toll‐like receptors (TLRs), widely expressed and highly conserved transmembrane receptors, are at the intersection of diet and metabolism, and may therefore be important determinants of weight gain and its sequellae. We sought specifically to determine the role of Tlr2 in the development of obesity and metabolic syndrome utilizing two dietary models that approximate contemporary diet compositions. Using C57BL/6 Hsd mice (wild type, WT) and mice with a targeted mutation in Tlr2 (Tlr2 ‐/‐ ), we showed that mice lacking TLR2 are substantially protected from diet‐induced adiposity, insulin resistance, hypercholesterolemia, and hepatic steatosis. In adipose tissue, Tlr2 deletion was associated with attenuation of adipocyte hypertrophy, as well as diminished macrophage infiltration and inflammatory cytokine expression.—Himes, R. W., Smith, C. W. Tlr2 is critical for diet‐induced metabolic syndrome in a murine model. FASEB J. 24, 731–739 (2010). www.fasebj.org
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Wallace, T. M., Levy, J. C., & Matthews, D. R. (2004) · Diabetes Care · doi:10.2337/diacare.27.6.1487 · Cited by 5,114
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
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Metadata
- Authors
- Himes, R. W., & Smith, C. W.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2009-10-19
- Volume
- 24
- Issue
- 3
- Pages
- 731-739
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2022495743
- Cited by
- 192
- References
- 9
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
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