Effects of gut microbes on nutrient absorption and energy regulation

Krajmalnik‐Brown, Rosa; Ilhan, Zehra‐Esra; Kang, Dae‐Wook; DiBaise, John K.

doi:10.1177/0884533611436116

Cited by 852Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesAnimal Nutrition and Physiology

Effects of gut microbes on nutrient absorption and energy regulation

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Krajmalnik‐Brown, Rosa, Ilhan, Zehra‐Esra, Kang, Dae‐Wook, DiBaise, John K.·2012·Nutrition in Clinical Practice

DOI 10.1177/0884533611436116PMC PMC3601187

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Abstract

Malnutrition may manifest as either obesity or undernutrition. Accumulating evidence suggests that the gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet. The composition of the gut microbiota has been shown to differ between lean and obese humans and mice; however, the specific roles that individual gut microbes play in energy harvest remain uncertain. The gut microbiota may also influence the development of conditions characterized by chronic low‐level inflammation, such as obesity, through systemic exposure to bacterial lipopolysaccharide derived from the gut microbiota. In this review, the role of the gut microbiota in energy harvest and fat storage is explored, as well as differences in the microbiota in obesity and undernutrition.

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The majority of carbohydrate-metabolizing microbes reside in the colon.
“where the majority of carbohydrate-metabolizing microbes reside (Krajmalnik-Brown et al., 2012).”
From Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women (2018) · cites this paper as Krajmalnik-Brown et al., 2012
If not for the colonic microbiota, indigestible carbohydrates and proteins would generally be eliminated via the stool without further absorption due to the limited digestive capability of the human large intestine.
“If not for the colonic microbiota, these nutrients would generally be eliminated via the stool without further absorption due to the limited digestive capability of the human large intestine [142].”
From The athletic gut microbiota (2020) · cites this paper as [142]
In healthy adults, approximately 85% of carbohydrates, 65-95% of proteins, and nearly all fats are absorbed before entering the large intestine.
“In healthy adults, ~ 85% of carbohydrates, 65–95% of proteins, and nearly all fats are absorbed before entering the large intestine [142].”
From The athletic gut microbiota (2020) · cites this paper as [142]
Even less is known about the gut microbiota in undernutrition compared to high-energy intake and obesity.
“In contrast to high-energy intake and obesity, even less is known about the gut microbiota in undernutrition [142].”
From The athletic gut microbiota (2020) · cites this paper as [142]

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2 retracted

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[90]Ley RE Turnbaugh PJ Klein S Gordon JI Microbial ecology: human gut microbes associated with obesity Nature 2006 444 7122 1022 1023 17183309
[140]Kondo S Xiao J-Z Satoh T Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity Biosci Biotechnol Biochem 2010 74 8 1656 1661 20699581

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Authors: Krajmalnik‐Brown, R., Ilhan, Z., Kang, D., & DiBaise, J. K.
Affiliations: Arizona State University (US)
Mayo Clinic in Arizona (US)
Corresponding author: DiBaise, John K.
ORCID: Krajmalnik‐Brown, Rosa
Ilhan, Zehra‐Esra
Kang, Dae‐Wook
DiBaise, John K.
Venue: Nutrition in Clinical Practice
Publisher: Wiley
Published: 2012-02-24
Volume: 27
Issue: 2
Pages: 201-214
ISSN: 0884-5336 (ISSN-L)
1941-2452
DOI: 10.1177/0884533611436116
PMC: PMC3601187
OpenAlex: W2113882071
Cited by: 852
References: 156
Citations by year: 2026: 43 · 2025: 82 · 2024: 132 · 2023: 105 · 2022: 103 · 2021: 78 · 2020: 79 · 2019: 55 · 2018: 42 · 2017: 58 · 2016: 24 · 2015: 20 · 2014: 16 · 2013: 8 · 2012: 7
FWCI: 1.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Nutrition in Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090379)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: gut microbiota, nutrient absorption, energy regulation, energy harvesting, fat deposition, obesity, malnutrition, low-grade inflammation, lipopolysaccharide
MeSH terms: Animals, Bacteria, Dietary Fats, Energy Metabolism, Humans, Inflammation, Intestinal Absorption, Lipopolysaccharides, Obesity, Gastrointestinal Tract, Malnutrition, Metagenome

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