A microscopic and macroscopic study of aging collagen on its molecular structure, mechanical properties, and cellular response
Open accessAbstract
During aging, collagen structure changes, detrimentally affecting tissues' biophysical and biomechanical properties due to an accumulation of advanced glycation end-products (AGEs). In this investigation, we conducted a parallel study of microscopic and macroscopic properties of different-aged collagens from newborn to 2-yr-old rats, to examine the effect of aging on fibrillogenesis, mechanical and contractile properties of reconstituted hydrogels from these collagens seeded with or without fibroblasts. In addition to fibrillogenesis of collagen under the conventional conditions, some fibrillogenesis was conducted alongside a 12-T magnetic field, and gelation rate and AGE content were measured. A nondestructive indentation technique and optical coherence tomography were used to determine the elastic modulus and dimensional changes, respectively. It was revealed that in comparison to younger specimens, older collagens exhibited higher viscosity, faster gelation rates, and a higher AGE-specific fluorescence. Exceptionally, only young collagens formed highly aligned fibrils under magnetic fields. The youngest collagen demonstrated a higher elastic modulus and contraction in comparison to the older collagen. We conclude that aging changes collagen monomer structure, which considerably affects the fibrillogenesis process, the architecture of the resulting collagen fibers and the global network, and the macroscopic properties of the formed constructs.
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One significant disadvantage of using human organs is the age-related changes of the extracellular matrix (ECM).
“One significant disadvantage of using human organs is the age-related changes of the extracellular matrix (ECM) [[30], [31], [32]].”
From Liver tissue engineering using decellularized scaffolds: Current progress, challenges, and opportunities (2024) · cites this paper as [32]
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- Authors
- Wilson, S. L., Guilbert, M., Sulé‐Suso, J., Torbet, J., Jeannesson, P., Sockalingum, G. D., & Yang, Y.
- Affiliations
- Keele University (GB)
- Centre National de la Recherche Scientifique (FR)
- University Hospitals of North Midlands NHS Trust (GB)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2013-09-11
- Volume
- 28
- Issue
- 1
- Pages
- 14-25
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2127586000
- Cited by
- 46
- References
- 51
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 4
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.lboro.ac.uk
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Loughborough University Institutional Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Loughborough University Research Repository (Loughborough University) (submittedVersion, cc-by-nc-nd)
- Funders
- Engineering and Physical Sciences Research Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- collagen aging, advanced glycation end products, fibril formation, collagen gel, fibroblast contraction, magnetic field alignment, elastic modulus, gelation rate, optical coherence tomography, indentation, tissue mechanics
- MeSH terms
- Aging, Animals, Collagen, Molecular Structure, Glycation End Products, Advanced, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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