Perivascular macrophage‐like melanocyte responsiveness to acoustic trauma—a salient feature of strial barrier associated hearing loss

Zhang, Fei; Dai, Min; Neng, Lingling; Zhang, Jin Hui; Zhi, Zhongwei; Fridberger, Anders; Shi, Xiaorui

doi:10.1096/fj.13-232892

Perivascular macrophage‐like melanocyte responsiveness to acoustic trauma—a salient feature of strial barrier associated hearing loss

Tissue perivascular resident macrophages (PVM/Ms), a hybrid cell type with characteristics of both macrophages and melanocytes, are critical for establishing and maintaining the endocochlear potential (EP) required for hearing. The PVM/Ms modulate expression of tight‐ and adherens‐junction protei…