The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.
L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions
Open accessAbstract
Summary: There is evidence that L‐tyrosine and L‐dihydroxyphenylalanine (L‐DOPA), besides serving as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not only as inducers and positive regulators of melanogenesis but also as regulators of other cellular functions. These can be mediated through action on specific receptors or through non‐receptor‐mediated mechanisms. The substrate induced (L‐tyrosine and/or L‐DOPA) melanogenic pathway would autoregulate itself as well as regulate the melanocyte functions through the activity of its structural or regulatory proteins and through intermediates of melanogenesis and melanin itself. Dissection of regulatory and autoregulatory elements of this process may elucidate how substrate‐induced autoregulatory pathways have evolved from prokaryotic or simple eukaryotic organisms to complex systems in vertebrates. This could substantiate an older theory proposing that receptors for amino acid‐derived hormones arose from the receptors for those amino acids, and that nuclear receptors evolved from primitive intracellular receptors binding nutritional factors or metabolic intermediates.
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Cites
Nitric Oxide and Peroxynitrite in Health and Disease
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Melanin pigmentation in mammalian skin and its hormonal regulation
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Self-citationPhysiological and Molecular Basis of Thyroid Hormone Action
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Pleiotropy in the melanocortin system, coloration and behavioural syndromes
DUCREST, A., KELLER, L., & ROULIN, A. (2008) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2008.06.001 · Cited by 847
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A Chemist's View of Melanogenesis
Ito, S. (2003) · Pigment Cell Research · doi:10.1034/j.1600-0749.2003.00037.x · Cited by 508
Simon, J. D., Peles, D., Wakamatsu, K., & Ito, S. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00610.x · Cited by 391 · cited 3×
“During eumelanogenesis, dopaquinones are transformed to leukodopachrome, followed by a series of oxido-reduction reactions producing the intermediates dihydroxyindole (DHI) and DHI carboxylic acid (DHICA), and finally forming eumelanin (Ito, 2003; Simon et al., 2009).”
BackgroundHuman pigmentation genes: identification, structure and consequences of polymorphic variation
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Cellular mechanisms regulating human melanogenesis
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Cited by
D'Orazio, J., Jarrett, S., Amaro-Ortiz, A., & Scott, T. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612222 · Cited by 1,984
Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452
Self-citationKey role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400
Self-citationDel Bino, S., Duval, C., & Bernerd, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092668 · Cited by 315
Metadata
- Authors
- Slominski, A., Zmijewski, M. A., & Pawelek, J.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2011-09-02
- Volume
- 25
- Issue
- 1
- Pages
- 14-27
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W1523735757
- Cited by
- 451
- References
- 91
- FWCI
- 9.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Slominski, A., Zmijewski, M. A., & Pawelek, J. (2012). L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions. Pigment Cell & Melanoma Research. https://doi.org/10.1111/j.1755-148x.2011.00898.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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