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Cited by 269

Glial cell influence on the human blood‐brain barrier

Prat, Alexandre, Biernacki, Katarzyna, Wosik, Karolina, Antel, Jack P.·2001·Glia
DOI 10.1002/glia.1104
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Abstract

The blood‐brain barrier (BBB) is a specialized structure of the central nervous system (CNS) that restricts immune cell migration and soluble molecule diffusion from the systemic compartment into the CNS. Astrocytes and microglia are resident cells of the CNS that contribute to the formation of the BBB. In this article, we consider the influence of these glial cells on the immune regulatory functions of the microvascular endothelium, with special emphasis on the human BBB. A series of in vitro studies demonstrate that soluble factors produced by glial cells, under basal culture conditions, help restrict development of inflammation within the CNS. These soluble factor effects include upregulating expression of molecules including HT7, UEA‐1 lectin‐binding sites, and angiotensin receptors that help define the phenotype of endothelial cells. These factors also induce tight junction formation between brain endothelial cells, contributing to the restricted permeability of the BBB. In contrast, these factors have little effect on expression of molecules by ECs that either promote lymphocyte migration, such as chemokines and adhesion molecules or molecules that are required for competent antigen presentation, such as MHC and co‐stimulatory molecules. Glial cells that become activated in response to signals derived from the immune system or generated within the CNS, produce an array of inflammatory molecules that increase permeability and promote lymphocyte trafficking and persistence. These observations emphasize the bidirectional nature of neural‐immune interactions; this dynamic system should be amenable to therapeutic interventions. GLIA 36:145–155, 2001. © 2001 Wiley‐Liss, Inc.

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  • Both pericytes and astrocytes can release Angiopoietin-1 that binds to endothelial Tie-2 receptors to improve brain vascular integrity.

    “both pericytes and astrocytes can release Angiopoietin-1 that binds to endothelial Tie-2 receptors to improve brain vascular integrity45,46.”

    From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [45]

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Authors
Prat, A., Biernacki, K., Wosik, K., & Antel, J. P.
Venue
Glia
Publisher
Wiley
Published
2001-10-02
Volume
36
Issue
2
Pages
145-155
ISSN
  • 0894-1491
  • 1098-1136
DOI
10.1002/glia.1104
Cited by
269
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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