The DOI matches its Crossref record; 102 of the 103 references it cites were found in a registry or an index.
Effects of bile acids on neurological function and disease
Open accessAbstract
Bile acids are synthesized from cholesterol and are known to be involved with the emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role, bile acids can act as cell signaling effectors through binding and activating receptors on both the cell membrane and nucleus. Numerous reports have investigated these signaling pathways in conditions where the liver is damaged. More recently, effort has been made to investigate the role of bile acids in diseases outside of those associated with liver damage. This review summarizes recent findings on the influences that bile acids can exert in normal neurological function and their contribution to diseases of the nervous system, with the intent of highlighting the role of these metabolites as potential players in neurological disorders.-McMillin, M., DeMorrow, S. Effects of bile acids on neurological function and disease.
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“BAs modulate HPA axis activity by inhibiting CRH release through FXR activation, expressed in the hypothalamus (309).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [309]
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Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
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Metadata
- Authors
- McMillin, M., & DeMorrow, S.
- Affiliations
- Texas A&M Health Science Center (US)
- Corresponding author
- DeMorrow, Sharon
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2016-07-28
- Volume
- 30
- Issue
- 11
- Pages
- 3658-3668
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- PMC
- PMC5067249
- OpenAlex
- W2491463486
- Cited by
- 192
- References
- 103
- Citations by year
- 2026: 24 · 2025: 20 · 2024: 27 · 2023: 18 · 2022: 29 · 2021: 28 · 2020: 19 · 2019: 15 · 2018: 8 · 2017: 3 · 2016: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The FASEB Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Health Services Research and Development
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK082435)
- Biomedical Laboratory Research and Development, VA Office of Research and Development (BX002638-01)
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
- Keywords
- bile acids, neurological function, neurological disorders, bile acid receptors, signal transduction, neuroprotection, liver injury, cholesterol metabolism, lipid emulsification
- MeSH terms
- Animals, Bile Acids and Salts, Cholesterol, Homeostasis, Humans, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear
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