Cited by 192Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismAldose Reductase and Taurine

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Effects of bile acids on neurological function and disease

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McMillin, Matthew, DeMorrow, Sharon·2016·The FASEB Journal

DOI 10.1096/fj.201600275rPMC PMC5067249

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Abstract

Bile acids are synthesized from cholesterol and are known to be involved with the emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role, bile acids can act as cell signaling effectors through binding and activating receptors on both the cell membrane and nucleus. Numerous reports have investigated these signaling pathways in conditions where the liver is damaged. More recently, effort has been made to investigate the role of bile acids in diseases outside of those associated with liver damage. This review summarizes recent findings on the influences that bile acids can exert in normal neurological function and their contribution to diseases of the nervous system, with the intent of highlighting the role of these metabolites as potential players in neurological disorders.-McMillin, M., DeMorrow, S. Effects of bile acids on neurological function and disease.

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Authors: McMillin, M., & DeMorrow, S.
Affiliations: Texas A&M Health Science Center (US)
Corresponding author: DeMorrow, Sharon
ORCID: McMillin, Matthew
DeMorrow, Sharon
Venue: The FASEB Journal
Publisher: Wiley
Published: 2016-07-28
Volume: 30
Issue: 11
Pages: 3658-3668
ISSN: 0892-6638 (ISSN-L)
1530-6860
DOI: 10.1096/fj.201600275r
PMC: PMC5067249
OpenAlex: W2491463486
Cited by: 192
References: 103
Citations by year: 2026: 24 · 2025: 20 · 2024: 27 · 2023: 18 · 2022: 29 · 2021: 28 · 2020: 19 · 2019: 15 · 2018: 8 · 2017: 3 · 2016: 1
FWCI: 0.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The FASEB Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Health Services Research and Development
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK082435)
Biomedical Laboratory Research and Development, VA Office of Research and Development (BX002638-01)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Aldose Reductase and Taurine
Keywords: bile acids, neurological function, neurological disorders, bile acid receptors, signal transduction, neuroprotection, liver injury, cholesterol metabolism, lipid emulsification
MeSH terms: Animals, Bile Acids and Salts, Cholesterol, Homeostasis, Humans, Liver, Signal Transduction, Receptors, Cytoplasmic and Nuclear

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Effects of bile acids on neurological function and disease

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