Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue

A simple, rapid, and sensitive DNA assay procedure

Labarca, C. G., & Paigen, K. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90165-7 · Cited by 4,865 · see citing works

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630 · see citing works

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

Boss, O., Samec, S., Paoloni‐Giacobino, A., Rossier, C., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00384-0 · Cited by 1,041 · see citing works

Sublines of mouse 3T3 cells that accumulate lipid

Green, H., & Kehinde, O. (1974) · Cell · doi:10.1016/0092-8674(74)90126-3 · Cited by 928 · see citing works

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 806 · see citing works

Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740 · see citing works

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

Vidal‐Puig, A., Solanes, G., Grujić, D., Flier, J. S., & Lowell, B. B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6740 · Cited by 711 · see citing works

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

Gimeno, R. E., Dembski, M., Weng, X., Deng, N., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Woolf, E. A., & Tartaglia, L. A. (1997) · Diabetes · doi:10.2337/diab.46.5.900 · Cited by 496 · see citing works

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

Zhou, Y.-T., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M.-Y., Trieu, F., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6386 · Cited by 373 · see citing works

Structure and function of the uncoupling protein from brown adipose tissue

Klingenberg, M., & Huang, S. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(98)00232-6 · Cited by 359 · see citing works

Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

Stansbie, D., Brownsey, R. W., Crettaz, M., & Denton, R. M. (1976) · Biochemical Journal · doi:10.1042/bj1600413 · Cited by 352 · see citing works

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

Millet, L., Vidal, H., Andréelli, F., Larrouy, D., Riou, J. P., Ricquier, D., Laville, M., & Langin, D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119811 · Cited by 351 · see citing works

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

Jabůrek, M., Vařecha, M., Gimeno, R. E., Dembski, M., Ježek, P., Zhang, M., Burn, P., Tartaglia, L. A., & Garlid, K. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26003 · Cited by 321 · see citing works

Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice

Surwit, R. S., Wang, S., Petro, A. E., Sanchı́s, D., Raimbault, S., Ricquier, D., & Collins, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4061 · Cited by 311 · see citing works

Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells.

Gimble, J. M., Robinson, C. E., Wu, X., Kelly, K. A., Rodriguez, B., Kliewer, S. A., Lehmann, J. M., & Morris, D. C. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09536-7 · Cited by 295 · see citing works

Body mass dependence of H+ leak in mitochondria and its relevance to metabolic rate

Porter, R. K., & Brand, M. D. (1993) · Nature · doi:10.1038/362628a0 · Cited by 257 · see citing works

Reversing adipocyte differentiation: Implications for treatment of obesity

Zhou, Y.-T., Wang, Z.-W., Higa, M., Newgard, C. B., & Unger, R. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2391 · Cited by 228 · see citing works

Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in Humans

Bouchard, C., Përusse, L., Chagnon, Y. C., Warden, C. H., & Ricquier, D. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1887 · Cited by 225 · see citing works

Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans

Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 191 · see citing works

Tumor Necrosis Factor Increases Mitochondrial Oxidant Production and Induces Expression of Uncoupling Protein–2 in the Regenerating Rat Liver

Lee, J. F. Y., Li, Y., Zhu, H., Yang, S., Lin, H. Z., Trush, M. A., & Diehl, A. M. (1999) · Hepatology · doi:10.1002/hep.510290320 · Cited by 155 · see citing works

Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution

Kopecký, J., Hodný, Z., Rossmeisl, M., Syrový, I., & Kozak, L. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e768 · Cited by 136 · see citing works

Conversion of carbohydrate to fat in adipose tissue: an energy-yielding and, therefore, self-limiting process

Flatt, J. P. (1970) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43004-4 · Cited by 135 · see citing works

Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.

Digby, J. E., Montague, C. T., Sewter, C. P., Sanders, L., Wilkison, W. O., O'Rahilly, S., & Prins, J. B. (1998) · Diabetes · doi:10.2337/diab.47.1.138 · Cited by 134 · see citing works

Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor.Preprint

Graves, R. A., Tontonoz, P., Ross, S. R., & Spiegelman, B. M. (1991) · Genes & Development · doi:10.1101/gad.5.3.428 · Cited by 132 · see citing works

Transgenic Mice Overexpressing the β1-Adrenergic Receptor in Adipose Tissue Are Resistant to Obesity

Soloveva, V., Graves, R. A., Rasenick, M. M., Spiegelman, B. M., & Ross, S. R. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.1.9870 · Cited by 109 · see citing works

Mechanisms of adaptation of glucose transporters to changes in the oxidative chain of muscle and fat cells

Bashan, N., Burdett, E., Gumà, A., Sargeant, R., Tumiati, L., Liu, Z., & Klip, A. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.2.c430 · Cited by 99 · see citing works

Uncoupling protein-2 gene: reduced mRNA expression in intraperitoneal adipose tissue of obese humans

Oberkofler, H., Liu, Y. M., Esterbauer, H., Hell, E., Krempler, F., & Patsch, W. (1998) · Diabetologia · doi:10.1007/s001250051011 · Cited by 97 · see citing works

Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology

Kopecký, J., Rossmeisl, M., Hodný, Z., Syrový, I., Horáková, M., & Kolarova, P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e776 · Cited by 81 · see citing works

The effect of 2,4-dinitrophenol on adipose-tissue metabolism

Rognstad, R., & Katz, J. J. (1969) · Biochemical Journal · doi:10.1042/bj1110431 · Cited by 76 · see citing works

Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue

Chascione, C., Elwyn, D. H., Davila, M., Gil, K. M., ASKANAZI, J., & Kinney, J. M. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.6.e664 · Cited by 69 · see citing works

Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice

Stefl, B., Janovská, A., Hodný, Z., Rossmeisl, M., Horáková, M., Syrový, I., Bémová, J., Bendlová, B., & Kopecký, J. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e527 · Cited by 69 · see citing works

Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes1

Valverde, Á. M., Teruel, T., Navarro, P., Benito, M., & Lorenzo, M. (1998) · Endocrinology · doi:10.1210/endo.139.3.5854 · Cited by 65 · see citing works

Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat.

Shillabeer, G., Hornford, J., Forden, J., Wong, N., & Lau, D. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42830-5 · Cited by 63 · see citing works

Effects of Obesity and Stable Weight Reduction on UCP2 and UCP3 Gene Expression in Humans

Vidal‐Puig, A., ROSENBAUM, M. S., Considine, R. V., Leibel, R. L., Dohm, G. L., & Lowell, B. B. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00694.x · Cited by 62 · see citing works

Fasting-mediated alteration studies in insulin action on lipolysis and lipogenesis in obese women

Arner, P., & Engfeldt, P. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.253.2.e193 · Cited by 59 · see citing works

Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice

Yoshida, T., Sakane, N., UMEKAWA, T., Kogure, A., Kondo, M., Kumamoto, K., Kawada, T., Nagase, I., & Saito, M. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800870 · Cited by 58 · see citing works

Lipogenesis in rat brown adipocytes. Effects of insulin and noradrenaline, contributions from glucose and lactate as precursors and comparisons with white adipocytes

SAGGERSON, E. D., McAllister, T. W. J., & Baht, H. S. (1988) · Biochemical Journal · doi:10.1042/bj2510701 · Cited by 56 · see citing works

β3-Adrenergic agonist induces a functionally active uncoupling protein in fat and slow-twitch muscle fibers

Yoshida, T., Umekawa, T., Kumamoto, K., Sakane, N., Kogure, A., Kondo, M., Wakabayashi, Y., Kawada, T., Nagase, I., & Saito, M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e469 · Cited by 46 · see citing works

Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential

Baumruk, F., Flachs, P., Horáková, M., Floryk, D., & Kopecký, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00053-8 · Cited by 43 · see citing works

Nutritional Regulation of Lipogenic Enzyme Gene Expression in Rat Epididymal Adipose Tissue

Iritani, N., Fukuda, H., & Tada, K. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021405 · Cited by 38 · see citing works

Carboxylation of Pyruvate by Isolated Rat Adipose Tissue Mitochondria

Patel, M. S., & Hanson, R. W. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63236-3 · Cited by 36 · see citing works

Octanoate Affects 2,4-Dinitrophenol Uncoupling in Intact Isolated Rat Hepatocytes

Sibille, B., Kériel, C., Fontaine, E. M., Catelloni, F., Rigoulet, M., & Leverve, X. M. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20724.x · Cited by 36 · see citing works

Transgenic Mice Overexpressing the 1-Adrenergic Receptor in Adipose Tissue Are Resistant to Obesity

Soloveva, V. (1997) · Molecular Endocrinology · doi:10.1210/me.11.1.27 · Cited by 36 · see citing works

Metabolism of pyruvate and malate by isolated fat-cell mitochondria

Martin, B. R., & Denton, R. M. (1971) · Biochemical Journal · doi:10.1042/bj1250105 · Cited by 32 · see citing works

Regulation of fatty acid synthesis and malonyl-CoA content in mouse brown adipose tissue in response to cold-exposure, starvation or re-feeding

Buckley, M. G., & Rath, E. A. (1987) · Biochemical Journal · doi:10.1042/bj2430437 · Cited by 27 · see citing works

Enzymes related to lipogenesis in the adipose tissue of obese subjects

Belfiore, F., Borzı̀, V., Napoli, E., & Rabuazzo, A. M. (1976) · Metabolism · doi:10.1016/0026-0495(76)90001-9 · Cited by 17 · see citing works

Mechanisms Whereby Prolactin Modulates Lipogenesis in Sheep Mammary Gland

Barber, M., Finley, E., & Vernon, R. G. (1991) · Hormone and Metabolic Research · doi:10.1055/s-2007-1003636 · Cited by 15 · see citing works

Tumor Necrosis Factor- Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes

Valverde, Á. M. (1998) · Endocrinology · doi:10.1210/en.139.3.1229 · Cited by 13 · see citing works

The energy balance of triacylglycerol metabolism in isolated rat adipocytes and the effect of insulin

Evans, R., & Garratt, C. (1977) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(77)90230-2 · Cited by 9 · see citing works

ATP balance and the effect of 2,4-dinitrophenol on fatty acid synthesis

Katz, J. J., Wals, P. A., & Rognstad, R. (1974) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(74)90105-2 · Cited by 2 · see citing works

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works

Mitochondrial dysfunction in obesity

Bournat, J. C., & Brown, C. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833c3026 · Cited by 471 · see citing works

FATTY ACIDS AS BIOCOMPOUNDS: THEIR ROLE IN HUMAN METABOLISM, HEALTH AND DISEASE - A REVIEW. PART 1: CLASSIFICATION, DIETARY SOURCES AND BIOLOGICAL FUNCTIONS

TVRZICKÁ, E., Kremmyda, L.-S., Staňková, B., & Žák, A. (2011) · Biomedical Papers · doi:10.5507/bp.2011.038 · Cited by 409 · see citing works

Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat

Flachs, P., Horakova, O., Brauner, P., Rossmeisl, M., Pecina, P., Franssen-van Hal, N., Ruzickova, J., Sponarova, J., Drahota, Z., Vlcek, C., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1944-7 · Cited by 388 · see citing works

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

Samudio, I. J., Fiegl, M., & Andreeff, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3722 · Cited by 309 · see citing works

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 284 · see citing works

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 270 · see citing works

Mitochondrial DNA depletion and morphologic changes in adipocytes associated with nucleoside reverse transcriptase inhibitor therapy

Nolan, D. A., Hammond, E., Martin, A. M., Taylor, L., Herrmann, S., McKinnon, E., Metcalf, C., Latham, B. I., & Mallal, S. A. (2003) · AIDS · doi:10.1097/00002030-200306130-00007 · Cited by 265 · see citing works

Isomer-Dependent Metabolic Effects of Conjugated Linoleic Acid

Roche, H. M., Noone, E., Sewter, C. P., Bennett, S. M., Savage, D. B., Gibney, M. J., O’Rahilly, S., & Vidal‐Puig, A. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2037 · Cited by 182 · see citing works

Nitric oxide and mitochondria

Guy, C. B. (2006) · Frontiers in bioscience · doi:10.2741/2122 · Cited by 173 · see citing works

Bioenergetic characterization of mouse podocytes

Abe, Y., Sakairi, T., Kajiyama, H., Shrivastav, S., Beeson, C. C., & Kopp, J. B. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2009 · Cited by 158 · see citing works

Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype

Flachs, P., Rossmeisl, M., Kuda, O., & Kopecký, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.003 · Cited by 149 · see citing works

Mitochondrial function/dysfunction in white adipose tissue

Boudina, S., & Graham, T. E. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.081414 · Cited by 146 · see citing works

Adipocytes Targets and Actors in the Pathogenesis of HIV-Associated Lipodystrophy and Metabolic Alterations

Gougeon, M., Pénicaud, L., Fromenty, B., Leclercq, P., Viard, J., & Capeau, J. (2004) · Antiviral Therapy · doi:10.1177/135965350400900206 · Cited by 129 · see citing works

Nitric oxide and mitochondria in metabolic syndrome

Litvinova, L. S., Atochin, D. N., Fattakhov, N. S., Василенко, М., Затолокин, П. А., & Кириенкова, Е. В. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00020 · Cited by 127 · see citing works

Bezafibrate Reduces mRNA Levels of Adipocyte Markers and Increases Fatty Acid Oxidation in Primary Culture of Adipocytes

Cabrero, À., Alegret, M., Sánchez, R. M., Adzet, T., Laguna, J. C., & Vázquez‐Carrera, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1883 · Cited by 124 · see citing works

Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases?

Hu, F., & Liu, F. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.05.008 · Cited by 112 · see citing works

Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids

Flachs, P., Rühl, R., Hensler, M., Janovská, P., Zouhar, P., Kůs, V., Jílková, Z. M., Papp, E., Kuda, O., Svobodová, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2233-2 · Cited by 109 · see citing works

A low molecular weight antioxidant decreases weight and lowers tumor incidence

Mitchell, J. B., Xavier, S., DeLuca, A. M., Sowers, A. L., Cook, J. A., Krishna, M. C., Hahn, S. M., & Russo, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01193-0 · Cited by 94 · see citing works

MitoNEET-mediated effects on browning of white adipose tissue

Kusminski, C. M., Park, J., & Scherer, P. E. (2014) · Nature Communications · doi:10.1038/ncomms4962 · Cited by 84 · see citing works

Mitochondria and endocrine function of adipose tissue

Medina‐Gómez, G. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.06.002 · Cited by 86 · see citing works

Metabolic Partitioning of Endogenous Fatty Acid in Adipocytes

Wang, T., 臧焰, Ling, W., Corkey, B. E., & Guo, W. (2003) · Obesity Research · doi:10.1038/oby.2003.121 · Cited by 77 · see citing works

Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo

Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovská, P., Horáková, M., Syrový, I., Cinti, S., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2002.02627.x · Cited by 75 · see citing works

Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores

Rossmeisl, M., Flachs, P., Brauner, P., Sponarova, J., Matejkova, O., Prazak, T., Ruzickova, J., Bardova, K., Kuda, O., & Kopecky, J. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802855 · Cited by 71 · see citing works

Inter-relations between osteoarthritis and metabolic syndrome: A common link?

Clanche, S. L., Bonnefont‐Rousselot, D., Sariali, E., Rannou, F., & Borderie, D. (2015) · Biochimie · doi:10.1016/j.biochi.2015.12.008 · Cited by 71 · see citing works

Overexpression of UCP-3 in Skeletal Muscle of Mice Results in Increased Expression of Mitochondrial Thioesterase mRNA

Moore, G. B. T., Himms‐Hagen, J., Harper, M., & Clapham, J. C. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4848 · Cited by 71 · see citing works

Dinitrophenol-induced mitochondrial uncoupling in vivo triggers respiratory adaptation in HepG2 cells

Desquiret‐Dumas, V., Loiseau, D., Jacques, C., Douay, O., Malthièry, Y., Ritz, P., & Roussel, D. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.11.005 · Cited by 69 · see citing works

Understanding adipose tissue development from transgenic animal models

Valet, P., Tavernier, G., Castan‐Laurell, I., Saulnier‐Blache, J. S., & Langin, D. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30458-2 · Cited by 69 · see citing works

Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat

Matejkova, O., Mustard, K. J., Sponarova, J., Flachs, P., Rossmeisl, M., Miksik, I., Thomason-Hughes, M., Grahame Hardie, D., & Kopecky, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.002 · Cited by 66 · see citing works

Body Mass Parameters, Lipid Profiles and Protein Contents of Zebrafish Embryos and Effects of 2,4-Dinitrophenol Exposure

Hachicho, N., Reithel, S., Miltner, A., Heipieper, H. J., Küster, E., & Luckenbach, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134755 · Cited by 63 · see citing works

Antiretoviral Therapy and the Lipodystrophy Syndrome, Part 2: Concepts in Aetiopathogenesis

Nolan, D. A., John, M., & Mallal, S. A. (2001) · Antiviral Therapy · doi:10.1177/135965350100600301 · Cited by 65 · see citing works

Tungstate Decreases Weight Gain and Adiposity in Obese Rats through Increased Thermogenesis and Lipid Oxidation

Claret, M., Corominola, H., Canals, I., Saura, J., Barceló-Batllori, S., Guinovart, J. J., & Gomis, R. (2005) · Endocrinology · doi:10.1210/en.2005-0385 · Cited by 60 · see citing works

Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management

Janković, A., Korać, A., Buzadžić, B., Stančić, A., Otašević, V., Ferdinándy, P., Daiber, A., & Korać, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13498 · Cited by 60 · see citing works

The anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler

Pardo‐Andreu, G. L., Núñez-Figueredo, Y., Tudella, V. G., Cuesta‐Rubio, O., Rodrigues, F. P., Pestana, C. R., Uyemura, S. A., Leopoldino, A. M., Alberici, L. C., & Curti, C. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.10.008 · Cited by 57 · see citing works

Dysregulation of epicardial adipose tissue in cachexia due to heart failure: the role of natriuretic peptides and cardiolipin

Janovská, P., Melenovský, V., Svobodová, M., Havlenova, T., Kratochvílová, H., Haluzı́k, M., Hošková, E., Pelikánová, T., Kautzner, J., Monzo, L., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12631 · Cited by 54 · see citing works

Effects of forced uncoupling protein 1 expression in 3T3–L1 cells on mitochondrial function and lipid metabolism.

Si, Y., Palani, S., Jayaraman, A., & Lee, K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600343-jlr200 · Cited by 50 · see citing works

Quantitation of Blood Lymphocyte Mitochondrial DNA for the Monitoring of Antiretroviral Drug–Induced Mitochondrial DNA Depletion

Petit, C., Mathez, D., Barthélémy, C., Lesté-Lasserre, T., Naviaux, R. K., Sonigo, P., & Leibowitch, J. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200308010-00006 · Cited by 50 · see citing works

Involvement of AMP‐activated protein kinase in fat depot‐specific metabolic changes during starvation

Sponarova, J., Mustard, K. J., Horakova, O., Flachs, P., Rossmeisl, M., Brauner, P., Bardová, K., Thomason-Hughes, M., Braunerová, R. T., Janovská, P., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.078 · Cited by 48 · see citing works

Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPARγ-independent mechanism, whereas TNFα-induced de-differentiation is PPARγ dependent

Tejerina, S., De Pauw, A., Vankoningsloo, S., Houbion, A., Renard, P., De Longueville, F., Raes, M., & Arnould, T. (2009) · Journal of Cell Science · doi:10.1242/jcs.027508 · Cited by 46 · see citing works

Augmenting energy expenditure by mitochondrial uncoupling: A role of AMP-activated protein kinase

Klaus, S., Keipert, S., Rossmeisl, M., & Kopecky, J. (2012) · Genes & Nutrition · doi:10.1007/s12263-011-0260-8 · Cited by 44 · see citing works

Non-Invasive Glucose Monitoring by NAD(P)H Autofluorescence Spectroscopy in Fibroblasts and Adipocytes: A Model for Skin Glucose Sensing

Evans, N. D., Gnudi, L., Rolinski, O. J., Birch, D. J. S., & Pickup, J. C. (2003) · Diabetes Technology & Therapeutics · doi:10.1089/152091503322527012 · Cited by 43 · see citing works

Targeted mitochondrial uncoupling beyond UCP1 – The fine line between death and metabolic health

Ost, M., Keipert, S., & Klaus, S. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.013 · Cited by 42 · see citing works

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

Cardoso, S., Correia, S. C., Carvalho, C., Candeias, E., Plácido, A. I., Duarte, A. I., Seiça, R. M. F., & Moreira, P. I. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9580-x · Cited by 41 · see citing works

A polymorphism in the promoter of UCP2 gene modulates lipid levels in patients with type 2 diabetes

Reis, A. F., Dubois‐Laforgue, D., Bellanné‐Chantelot, C., Timsit, J., & Velho, G. (2004) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2004.06.008 · Cited by 41 · see citing works

Impact of perturbed pyruvate metabolism on adipocyte triglyceride accumulation

Si, Y., Shi, H., & Lee, K. (2009) · Metabolic Engineering · doi:10.1016/j.ymben.2009.08.001 · Cited by 40 · see citing works

Systems biology of antioxidants

Andriantsitohaina, R., Duluc, L., Rodríguez, J., del Valle, L. G., Guevara-García, M., Simard, G., Soleti, R., Su, D., Velázquez‐Pérez, L., Wilson, J. X., et al. (2012) · Clinical Science · doi:10.1042/cs20110643 · Cited by 39 · see citing works

Association of Uncoupling Protein 1 (UCP1) gene polymorphism with obesity: a case-control study

Chathoth, S., Ismail, M. H., Vatte, C., Cyrus, C., Al-Ali, Z. A., Ahmed, K. A., Acharya, S., Barqi, A. M. A., & Ali, A. A. (2018) · BMC Medical Genetics · doi:10.1186/s12881-018-0715-5 · Cited by 38 · see citing works

Metabolic Flux Analysis of Mitochondrial Uncoupling in 3T3-L1 Adipocytes

Si, Y., Shi, H., & Lee, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007000 · Cited by 33 · see citing works

Energy metabolism of adipose tissue – physiological aspects and target in obesity treatment

Kopecký, J., Rossmeisl, M., Flachs, P., Brauner, P., Sponarova, J., Matejkova, O., Prazak, T., Růžičková, J., Bardová, K., & Kuda, O. (2004) · Physiological Research · doi:10.33549/physiolres.930000.53.s225 · Cited by 30 · see citing works

White and beige adipocytes: are they metabolically distinct?

Sepa-Kishi, D. M., & Ceddia, R. B. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0003 · Cited by 29 · see citing works

Concordant mRNA Expression of UCP-3, but Not UCP-2, with Mitochondrial Thioesterase-1 in Brown Adipose Tissue and Skeletal Muscle in db/db Diabetic Mice

Clapham, J. C., Coulthard, V. H., & Moore, G. B. T. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5698 · Cited by 25 · see citing works

Resveratrol and genistein as adenosine triphosphate–depleting agents in fat cells

Szkudelska, K., Nogowski, L., & Szkudelski, T. (2010) · Metabolism · doi:10.1016/j.metabol.2010.07.006 · Cited by 24 · see citing works

Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels

Flachs, P., Novotný, J., Baumruk, F., Bardová, K., Bouřová, L., Mikšı́k, I., Sponarova, J., Svoboda, P., & Kopecký, J. (2002) · Biochemical Journal · doi:10.1042/bj20011438 · Cited by 24 · see citing works

Triglyceride-lowering Effect of Respiratory Uncoupling in White Adipose Tissue

Rossmeisl, M., Kovar, J., Syrovy, I., Flachs, P., Bobkova, D., Kolar, F., Poledne, R., & Kopecky, J. (2005) · Obesity Research · doi:10.1038/oby.2005.96 · Cited by 23 · see citing works

Modulation of Lipid Metabolism by Energy Status of Adipocytes

Kopecký, J., Flachs, P., Bardová, K., Brauner, P., Prazak, T., & Sponarova, J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04267.x · Cited by 23 · see citing works

Stress of endoplasmic reticulum modulates differentiation and lipogenesis of human adipocytes

Koc, M., Mayerová, V., Kračmerová, J., Mairal, A., Mališová, L., Štich, V., Langin, D., & Rossmeislová, L. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.090 · Cited by 22 · see citing works

Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice

de Melo, D. G., Anaruma, C. P., Rodrigues, K. C. D. C., Pereira, R. M., de Campos, T. D. P., Canciglieri, R. D. S., Ramos, C. O., Cintra, D. E., Ropelle, E. R., da Silva, A. S. R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10688-w · Cited by 21 · see citing works

ProlongedNrf1overexpression triggers adipocyte inflammation and insulin resistance

van Tienen, F. H. J., Lindsey, P. J., Kallen, C., & Smeets, H. J. M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22889 · Cited by 21 · see citing works

Reduced Activity and Expression of Mitochondrial Citrate Carrier in Streptozotocin-Induced Diabetic Rats

Gnoni, G. V., Giudetti, A. M., Mercuri, E., Damiano, F., Stanca, E., Priore, P., & Siculella, L. (2010) · Endocrinology · doi:10.1210/en.2009-1352 · Cited by 19 · see citing works

Effect of Sutherlandia frutescens on the Lipid Metabolism in an Insulin Resistant Rat Model and 3T3‐L1 Adipocytes

Mackenzie, J., Koekemoer, T., Roux, S., van de Venter, M., & Dealtry, G. (2012) · Phytotherapy Research · doi:10.1002/ptr.4653 · Cited by 18 · see citing works

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression

Šrámková, V., Koc, M., Krauzová, E., Kračmerová, J., Šiklová, M., Elkalaf, M., Langin, D., Štich, V., & Rossmeislová, L. (2019) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00676-6 · Cited by 17 · see citing works

Physiological regulation and metabolic role of browning in white adipose tissue

Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14 · see citing works

Effects of mitochondrial uncoupling on adipocyte intracellular Ca2+ and lipid metabolism

Sun, X. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00004-4 · Cited by 12 · see citing works

Site-Specific Reduction of Oxidative and Lipid Metabolism in Adipose Tissue of 3′-Azido-3′-Deoxythymidine-Treated Rats

Deveaud, C., Beauvoit, B. P., Reynaud, A., & Bonnet, J. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01078-06 · Cited by 11 · see citing works

Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction

Pauw, A. D., Demine, S., Tejerina, S., Dieu, M., Delaive, E., Kel, A. E., Renard, P., Raes, M. J., & Arnould, T. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2011 · Cited by 10 · see citing works

The past-tense debate

Pinker, S. A., & Ullman, M. T. (2002) · Cited by 8 · see citing works

Mitochondrial targets exploration of epigallocatechin gallate and theaflavin in regards to differences in stress protection under different temperatures

Zhang, M., Li, B., & Tian, J. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109400 · Cited by 8 · see citing works

Fourier transform infrared immunosensors for model hapten molecules

Gosselin, E., Gorez, M., Voué, M., Denis, O., Conti, J., Popović, N. Đ., Cauwenberge, A. V., Noel, E., & Coninck, J. D. (2009) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2009.01.001 · Cited by 7 · see citing works

A synonymous mutation of uncoupling protein 2 (UCP2) gene is associated with growth performance, carcass characteristics and meat quality in rabbits

Liu, W., & Lai, S. (2016) · Journal of Animal Science and Technology · doi:10.1186/s40781-016-0086-4 · Cited by 6 · see citing works

Effect of Different Fatty Acid Types on Mitochondrial Dysfunction Associated With Brown and Beige Adipose Tissue

Ferreira, Y. A. M., Estadella, D., & Pisani, L. P. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf048 · Cited by 5 · see citing works

Obesity, mitochondrial dysfunction, and obstructive lung disease

Chaudhuri, R., Thompson, M. A., Pabelick, C. M., Agrawal, A., & Prakash, Y. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813553-2.00007-5 · Cited by 3 · see citing works

Association of the UCP2 –866G/A polymorphism with type 2 diabetes and obesity in Saudi population

Tayeb, M. T. (2009) · Egyptian Journal of Medical Human Genetics · Cited by 3 · see citing works

Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland

Jeong, S., Lee, S. G., Kim, K. H., Zhu, X., Lee, W. K., Lee, H. Y., Park, S., Lee, M., Cheng, S.-Y., Lee, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.966644 · Cited by 2 · see citing works

Polychlorinated biphenyls

Blanc, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-88462-4.00013-4 · Cited by 2 · see citing works

Development of obesity-induced inflammation and insulin resistance: The role of adipose tissue, fatty acids, and toll-like receptors

Davis, J. E. (2008) · doi:10.31274/etd-180810-1101 · Cited by 1 · see citing works

Papel de la proteína desacoplante UCP2 en el estrés oxidativo provocado por la metformina en el adipocito blanco

Anedda, A. (2010) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

Deciphering mitochondrial and molecular pathology in Type 2 Diabetes Mellitus

van Tienen, F. H. J. (2011) · doi:10.26481/dis.20110204ft

Mitochondrial Dysfunction and AKT Isoform-Specific Regulation in 3T3-L1 Adipocytes: A Dissertation

Shi, X. (2010) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/zv35-6223

Evaluating Mitochondrial Uncoupling Potentials Of A7E And DNP In Saccharomyces cerevisiae: Implications For Human Obesity.

Vaughan, R. A., Dichosa, A. E. K., & Conn, C. A. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000385007.04804.4e

Improving Glucocorticoid Therapy in Chronic Lymphocytic Leukemia

Tung, S. (2013) · TSpace (University of Toronto)

Peran biologis Uncoupling Protein 2 (UCP2) pada obesitas dan diabetes mellitus tipe 2 (DMT2)

Susmiarsih, T. P. (2021) · Jurnal Kedokteran YARSI · doi:10.33476/jky.v14i3.1850

Treinamento de força de curta duração induz alterações no perfil de ácidos graxos e adaptações termogênicas no tecido adiposo subcutâneo de camundongos obesos

de Melo, D. G. (2020) · doi:10.47749/t/unicamp.2020.1157905

Association of regulatory polymorphisms of gene expression with color phenotypes, water holding capacity, and pH of Nellore meat

Lima, B. D. (2024) · doi:10.11606/d.11.2024.tde-08042024-115109

Regulation of lipogenesis in human adipose tissue : effect of metabolic stress, dietary intervention and aging

Šrámková, V. (2017) · doi:10.70675/ebd7c64ezd314z423cza964z025db5744b2d

Mitochondrial homeostasis and aging: Mechanisms, disease associations, and targeted intervention strategies

Bao-Sheng, W. A. N. G., & Ben, Z. H. O. U. (2026) · Shengming kexue · doi:10.3724/cbls.2026103

Polychlorinated biphenyls

Blanc, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00038-5

Pathogenesis of HIV Lipodystrophy

Shikuma, C. M., Souza, S. A., & Shiramizu, B. T. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0471-9_7

Mitochondrial uncoupling and lipid metabolism in adipocytes

Kopecký, J., Rossmeisl, M., Flachs, P., Bardová, K., & Brauner, P. (2001) · Biochemical Society Transactions · doi:10.1042/0300-5127:0290791 · Cited by 1 · see citing works

Metabolic Flux Analysis of Mitochondrial Uncoupling in 3T3-L1 Adipocytes

Si, Y., Shi, H., & Lee, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007000 · Cited by 33 · see citing works

Metabolic Flux Analysis of Mitochondrial Uncoupling in

Adipocytes, T.-L., & Si, Y. (2009)

Effects of forced uncoupling protein 1 expression in 3T3–L1 cells on mitochondrial function and lipid metabolism.

Si, Y., Palani, S., Jayaraman, A., & Lee, K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600343-jlr200 · Cited by 50 · see citing works

Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo

Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovská, P., Horáková, M., Syrový, I., Cinti, S., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2002.02627.x · Cited by 75 · see citing works