Case Report: Testosterone Treatment of Systemic Lupus Erythematosus in a Patient With Klinefelter’s Syndrome
Abstract
Systemic lupus erythematosus occurs with much greater frequency in females than in males, and in some reports, researchers suggested that treatment with androgenic hormones might have therapeutic effects in this disease. The authors report a case of systemic lupus erythematosus in a hypogonadal male with Klinefelter's syndrome who was treated with testosterone in doses sufficient to normalize the serum level of this hormone to the adult male range. Hematologic and serologic abnormalities, including elevated levels of anti-DNA antibodies and depressed complement levels, returned to normal within 9 months of increasing the testosterone dose. The findings in this patient indicate that androgenic steroids can exert significant effects on immune parameters, and suggest that effects of androgens on the immune system may contribute to the sexual dimorphism of autoimmune disease.
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Case reports and randomised controlled trials of androgen therapy in inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus have found androgens improve clinical status and reduce inflammatory markers.
“There are several case reports and randomised controlled trials of androgen therapy in patients with inflammatory disease such as rheumatoid arthritis or systemic lupus erythematosus in which androgens have been found to improve clinical status and reduce inflammatory markers.[33][34][35]”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [35]
Cites
Low plasma androgens in women with systemic lupus erythematosus
Lahita, R. G., Bradlow, H. L., Ginzler, E. M., Pang, S., & New, M. I. (1987) · Arthritis & Rheumatism · doi:10.1002/art.1780300301 · Cited by 284 · see citing works
BIZZARRO, A., VALENTINI, G., MARTINO, G. D., DAPONTE, A., DE BELLIS, A., & IACONO, G. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-32 · Cited by 186 · see citing works
Low plasma androgens in women with active or quiescent systemic lupus erythematosus
Jungers, P., NAHOUL, K., Pelissier, C., Dougados, M., Tron, F., & Bach, J. (1982) · Arthritis & Rheumatism · doi:10.1002/art.1780250415 · Cited by 112 · see citing works
Agnello, V., Pariser, K. M., Gell, J., Gelfand, J., & Turksoy, R. N. (1983) · PubMed · Cited by 71 · see citing works
Systemic lupus erythematosus and Klinefelter's syndrome.
French, M. A., & Hughes, P. J. (1983) · Annals of the Rheumatic Diseases · doi:10.1136/ard.42.4.471 · Cited by 64 · see citing works
Systemic lupus erythematosus: two patients treated with danazol
Morley, K. D., Parke, A. L., & Hughes, G. R. (1982) · BMJ · doi:10.1136/bmj.284.6327.1431 · Cited by 56 · see citing works
Ten cases of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibody
Beutner, E. H., Chorzelski, T. P., Parodi, A., et al. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(08)80367-2 · Cited by 48 · see citing works
Rg, L., Cheng, C. Y., Monder, C., & Cw, B. (1992) · PubMed · Cited by 47 · see citing works
EFFECT OF ENDOGENOUS ANDROGENS ON LYMPHOCYTE SUBPOPULATIONS
Taino, V.-M., Savilahti, E., & Eskola, J. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92755-2 · Cited by 15 · see citing works
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Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031069 · Cited by 731 · see citing works
Malkin, C. J., Pugh, P. J., Morris, P. D., Kerry, K. E., Jones, R. D., Jones, T. H., & Channer, K. S. (2004) · Heart · doi:10.1136/hrt.2003.021121 · Cited by 250 · see citing works
- Authors
- Olsen, N. J., & Kovacs, W. J.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Olsen, Nancy J.
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 310
- Issue
- 4
- Pages
- 158-160
- ISSN
- 0002-9629 (ISSN-L)
- OpenAlex
- W178806353
- Cited by
- 79
- References
- 9
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- systemic lupus erythematosus, Klinefelter syndrome, testosterone replacement therapy, androgens, hypogonadism, anti-DNA antibodies, complement levels, sex differences in autoimmune disease, immunomodulation
- MeSH terms
- Adolescent, Antibodies, Antinuclear, Humans, Klinefelter Syndrome, Lupus Erythematosus, Systemic, Male, Testosterone, Antigens, CD
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