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Cited by 189Treatment of Major DepressionAnesthesia and Sedative AgentsAnesthesia and Pain Management

Small-Dose Ketamine Improves the Postoperative State of Depressed Patients

Kudoh, Akira, Takahira, Yoko, Katagai, Hiroshi, Takazawa, Tomoko·2002·Anesthesia & Analgesia
DOI 10.1097/00000539-200207000-00020
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Abstract

UNLABELLED: We investigated whether ketamine is suitable for depressed patients who had undergone orthopedic surgery. We studied 70 patients with major depression and 25 patients as the control (Group C). The depressed patients were divided randomly into two groups; patients in Group A (n = 35) were induced with propofol, fentanyl, and ketamine and patients in Group B (n = 35) were induced with propofol and fentanyl, and all patients were maintained with 1.5%-2.0% isoflurane plus nitrous oxide. The mean Hamilton Depression Rating (HDR) score was 12.7 +/- 5.4 for Group A and 12.3 +/- 6.0 for Group B 2 days before surgery and 9.9 +/- 4.1 for Group A and 14.4 +/- 3.8 for Group B 1 day after surgery. The HDR score in Group A 1 day after surgery was significantly (P < 0.05) lower than that in Group B. The HDR score in Group C was 4.2 +/- 1.7 2 days before surgery and 4.8 +/- 1.6 1 day after surgery. Depressed mood, suicidal tendencies, somatic anxiety, and hypochondriasis significantly decreased in Group A as compared with Group B. Postoperative pain scores in Group A at 8 and 16 h after the end of anesthesia were 26.6 +/- 8.7 and 24.9 +/- 8.2, respectively, which were significantly (P < 0.05) lower than 34.3 +/- 12.0 and 31.1 +/- 8.8 in Group B. In conclusion, small-dose ketamine improved the postoperative depressive state and relieved postoperative pain in depressed patients. IMPLICATIONS: NMDA receptor antagonists are reported to be effective for improving depression. It remains unclear whether ketamine, which is an NMDA receptor antagonist, postoperatively affects the psychological state in depressed patients. We investigated the effect of 1.0 mg/kg of ketamine on postoperative outcomes in depressed patients.

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Crossref · 10.1097/00000539-200207000-00020

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  • Intraoperative ketamine administration can improve postoperative mood even though patients were unconscious at the time of administration.

    “several studies have demonstrated that intraoperative ketamine administration can improve postoperative mood even though the patients were unconscious at the time of administration”

    From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [229]

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Authors
Kudoh, A., Takahira, Y., Katagai, H., & Takazawa, T.
Affiliations
Hirosaki National Hospital (JP)
Corresponding author
Kudoh, Akira
Venue
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-07
Volume
95
Issue
1
Pages
114-118
ISSN
0003-2999 (ISSN-L)
DOI
10.1097/00000539-200207000-00020
OpenAlex
W2123476505
Cited by
189
References
1
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 8 · 2020: 13 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 3
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • Anesthesia & Analgesia (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
Keywords
ketamine, depression, major depressive disorder, orthopedic surgery, postoperative depression, postoperative pain, NMDA receptor antagonists, isoflurane, propofol, fentanyl, Hamilton Depression Rating Scale, suicidality, somatic anxiety, health anxiety
MeSH terms
Adult, Anesthesia, General, Anesthetics, Dissociative, Depressive Disorder, Female, Humans, Ketamine, Male, Middle Aged, Pain Measurement, Pain, Postoperative, Postoperative Pain, Postoperative Period, Psychiatric Status Rating Scales, Blood Loss, Surgical

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