Novel glutamatergic agents for major depressive disorder and bipolar disorder

Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report

Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works

Glutamate uptake

Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works

Cloned Glutamate Receptors

Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works

Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice

Trivedi, M. H., Rush, A. J., Wisniewski, S. R., Nierenberg, A. A., Warden, D., Ritz, L., Norquist, G., Howland, R. H., Lebowitz, B., McGrath, P. J., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.28 · Cited by 3,879 · see citing works

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works

Glutamate receptor ion channels

Mayer, M. L. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.05.004 · Cited by 3,645 · see citing works

The Glutamate Receptor Ion Channels

Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

Molecular diversity of glutamate receptors and implications for brain function

Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543 · see citing works

Evidence-based health policy—lessons from the Global Burden of Disease Study

Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178 · see citing works

The Long-term Natural History of the Weekly Symptomatic Status of Bipolar I Disorder

Judd, L. L., Akiskal, H. S., Schettler, P. J., Endicott, J., Maser, J., Solomon, D. A., Leon, A. C., Rice, J. A., & Keller, M. B. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.530 · Cited by 2,106 · see citing works

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works

Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex

Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works

NMDA receptor subunits: diversity, development and disease

Cull-Candy, S., Brickley, S., & Farrant, M. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00215-4 · Cited by 1,694 · see citing works

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518 · see citing works

PDZ Domains and the Organization of Supramolecular Complexes

Sheng, M., & Sala, C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1 · Cited by 1,191 · see citing works

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works

Cingulate function in depression: a potential predictor of treatment response

Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., Silva, J. A., McGinnis, S., Glass, T. G., Martin, C. C., et al. (1997) · NeuroReport · doi:10.1097/00001756-199703030-00048 · Cited by 1,029 · see citing works

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963 · see citing works

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · see citing works

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

Trullas, R., & Skolnick, P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90204-j · Cited by 785 · see citing works

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

aan het Rot, M., Collins, K. A., Murrough, J. W., Perez, A. M., Reich, D. L., Charney, D. S., & Mathew, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.038 · Cited by 690 · see citing works

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works

Anterior Cingulate Activity as a Predictor of Degree of Treatment Response in Major Depression: Evidence From Brain Electrical Tomography Analysis

Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Koger, J. V., Benca, R. M., & Davidson, R. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.405 · Cited by 630 · see citing works

Control of Glutamate Clearance and Synaptic Efficacy by Glial Coverage of Neurons

Oliet, S. H. R., Piet, R., & Poulain, D. A. (2001) · Science · doi:10.1126/science.1059162 · Cited by 623 · see citing works

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works

Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

Price, R. B., Nock, M. K., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.029 · Cited by 600 · see citing works

Rapid Resolution of Suicidal Ideation After a Single Infusion of an <i>N</i> -Methyl- <scp>D</scp> -Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

DiazGranados, N., Ibrahim, L. A., Brutsche, N. E., Ameli, R., Henter, I. D., Luckenbaugh, D. A., Machado-Vieira, R., & Zarate, C. A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05327blu · Cited by 564 · see citing works

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works

Subunit-Specific NMDA Receptor Trafficking to Synapses

Barria, A., & Malinow, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00776-6 · Cited by 515 · see citing works

Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders

Yüksel, Ç., & Öngür, D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.016 · Cited by 493 · see citing works

Memories of NMDA receptors and LTP

Collingridge, G. L., & Bliss, T. V. P. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80016-u · Cited by 493 · see citing works

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Barbosa, L. M., Andreazza, A. C., Stertz, L., Fries, G. R., Gavioli, E. C., Kapczinski, F., et al. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.027 · Cited by 454 · see citing works

Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders

Beneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works

Glutamate and Depression: Clinical and Preclinical Studies

PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · cited 1× · see citing works

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

Song, I., Kamboj, S. K., Xia, J., Dong, H., Liao, D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80548-6 · Cited by 398 · see citing works

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Cosford, N. D. P., Tehrani, L. R., Roppe, J. R., Schweiger, E. J., Smith, N. D., Anderson, J., Bristow, L. J., Brodkin, J. D., Jiang, X., McDonald, I. A., et al. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025570j · Cited by 397 · see citing works

A Double-Blind, Placebo-Controlled Study of Memantine in the Treatment of Major Depression

Zarate, C. A., Singh, J. B., Quiroz, J. A., De Jesus, G., Denicoff, K. K., Luckenbaugh, D. A., Manji, H. K., & Charney, D. S. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.153 · Cited by 387 · see citing works

Neuropharmacology of AMPA and kainate receptors

Bleakman, D., & Lodge, D. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00139-7 · Cited by 363 · see citing works

Brain Imaging Correlates of Depressive Symptom Severity and Predictors of Symptom Improvement After Antidepressant Treatment

Chen, C.-H., Ridler, K., Suckling, J., Williams, S., Fu, C. H. Y., Merlo-Pich, E., & Bullmore, E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.018 · Cited by 354 · see citing works

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

Skolnick, P., Layer, R. T., Popik, P., Nowak, G., Paul, I. A., & Trullás, R. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979537 · Cited by 344 · see citing works

Diverse mechanisms of antiepileptic drugs in the development pipeline

Rogawski, M. A. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2006.02.004 · Cited by 340 · see citing works

Prediction of Antidepressant Effects of Sleep Deprivation by Metabolic Rates in the Ventral Anterior Cingulate and Medial Prefrontal Cortex

Wu, J. C., Buchsbaum, M. S., Gillin, J. C., Tang, C. Y., Cadwell, S., Wiegand, M. H., Najafi, A., Klein, E., Hazen, K., & Bunney, W. E. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1149 · Cited by 327 · see citing works

An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression

Zarate, C. A., Payne, J. L., Quiroz, J. A., Sporn, J., Denicoff, K. K., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.171 · Cited by 324 · see citing works

Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.043 · Cited by 314 · see citing works

Cure therapeutics and strategic prevention: raising the bar for mental health research

Insel, T. R., & Scolnick, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001777 · Cited by 313 · see citing works

Glutamate and the Neural Basis of the Subjective Effects of Ketamine: A Pharmaco–Magnetic Resonance Imaging Study

Deakin, J. F. W., Lees, J., McKie, S., Hallak, J. E. C., Williams, S. R., & Dursun, S. M. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.37 · Cited by 311 · see citing works

Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation

Hashimoto, R., Hough, C. J., Nakazawa, T., Yamamoto, T. S., & Chuang, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00728.x · Cited by 310 · see citing works

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Porter, R. H. P., Jaeschke, G., Spooren, W., Ballard, T. M., Büttelmann, B., Kolczewski, S., Peters, J.-U., Prinssen, E., Wichmann, J., Vieira, E., et al. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.089839 · Cited by 308 · see citing works

Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin

Jabaudon, D., Shimamoto, K., Yasuda‐Kamatani, Y., Scanziani, M., Gähwiler, B. H., & Gerber, U. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8733 · Cited by 305 · see citing works

Remission Rates Following Antidepressant Therapy With Bupropion or Selective Serotonin Reuptake Inhibitors: A Meta-Analysis of Original Data From 7 Randomized Controlled Trials

Thase, M. E., Haight, B. R., Richard, N., Rockett, C. B., Mitton, M., Modell, J. G., VanMeter, S., Harriett, A. E., & Wang, Y. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0803 · Cited by 304 · see citing works

Neurobiological and clinical effects of the antidepressant tianeptine

Kasper, S., & McEwen, B. S. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00002 · Cited by 302 · see citing works

Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial

Mathew, S. J., Murrough, J. W., Rot, M. A. H., Collins, K. A., Reich, D. L., & Charney, D. S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000169 · Cited by 296 · see citing works

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

Svenningsson, P., Bateup, H. S., Qi, H., Takamiya, K., Huganir, R. L., Spedding, M., Roth, B. L., McEwen, B. S., & Greengard, P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05952.x · Cited by 287 · see citing works

Kainate receptors and synaptic transmission

Huettner, J. E. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00122-9 · Cited by 285 · see citing works

Increased Anterior Cingulate Cortical Activity in Response to Fearful Faces: A Neurophysiological Biomarker that Predicts Rapid Antidepressant Response to Ketamine

Salvadore, G., Cornwell, B. R., Colon-Rosario, V., Coppola, R., Grillon, C., Zarate, C. A., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.014 · Cited by 277 · see citing works

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272 · see citing works

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

Chaki, S., Yoshikawa, R., Hirota, S., Shimazaki, T., Maeda, M., Kawashima, N., Yoshimizu, T., Yasuhara, A., Sakagami, K., Okuyama, S., et al. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.10.009 · Cited by 254 · see citing works

Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: A systematic review of the in vivo proton magnetic resonance spectroscopy findings

Yildiz-Yesiloglu, A., & Ankerst, D. P. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.012 · Cited by 253 · see citing works

Treatment-Resistant Bipolar Depression: A STEP-BD Equipoise Randomized Effectiveness Trial of Antidepressant Augmentation With Lamotrigine, Inositol, or Risperidone

Nierenberg, A. A., Ostacher, M. J., Calabrese, J. R., Ketter, T. A., Marangell, L. B., Miklowitz, D. J., Miyahara, S., Bauer, M. S., Thase, M. E., Wisniewski, S. R., et al. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.210 · Cited by 250 · see citing works

Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1

Fumagalli, E. R., Funicello, M., Rauen, T., Gobbi, M., & Mennini, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.10.023 · Cited by 248 · see citing works

Response and remission rates in different subpopulations with major depressive disorder administered venlafaxine, selective serotonin reuptake inhibitors, or placebo

Entsuah, A. R., Huang, H., & Thase, M. E. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n1106 · Cited by 245 · see citing works

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

Paul, I. A., Nowak, G., Layer, R. T., Popik, P., & Skolnick, P. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38715-x · Cited by 241 · see citing works

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

Svenningsson, P., Tzavara, E. T., Witkin, J. M., Fienberg, A. A., Nomikos, G. G., & Greengard, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052712799 · Cited by 229 · see citing works

Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses

Law, A. J., & Deakin, J. F. W. (2001) · Neuroreport · doi:10.1097/00001756-200109170-00043 · Cited by 227 · see citing works

AMPA Receptor Potentiators for the Treatment of CNS Disorders

O’Neill, M. J., Bleakman, D., Zimmerman, D. M., & Nisenbaum, E. S. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337508 · Cited by 223 · see citing works

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

Pałucha-Poniewiera, A., & Pilc, A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.007 · Cited by 220 · see citing works

Anterior Cingulate Desynchronization and Functional Connectivity with the Amygdala During a Working Memory Task Predict Rapid Antidepressant Response to Ketamine

Salvadore, G., Cornwell, B. R., Sambataro, F., Latov, D. R., Colon-Rosario, V., Carver, F. W., Holroyd, T., Diazgranados, N., Machado‐Vieira, R., Grillon, C., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.24 · Cited by 217 · see citing works

Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures

Frizzo, M. E., Dall’Onder, L. P., Dalcin, K. B., & Souza, D. O. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000012717.37839.07 · Cited by 213 · see citing works

Genetic Markers of Suicidal Ideation Emerging During Citalopram Treatment of Major Depression

Laje, G., Paddock, S., Manji, H. K., Rush, A. J., Wilson, A. F., Charney, D. S., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122018 · Cited by 213 · see citing works

Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression

Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., & Baxter, L. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.522 · Cited by 210 · see citing works

Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes

Debono, M.-W., Guern, J. L., Canton, T., Doble, A., & Pradier, L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90147-a · Cited by 210 · see citing works

Genetic Inactivation of the NMDA Receptor NR2A Subunit has Anxiolytic- and Antidepressant-Like Effects in Mice

Boyce‐Rustay, J. M., & Holmes, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301039 · Cited by 209 · see citing works

The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Membrane Localization: Relationship to Clinical Effects in Mood Disorders

Du, J., Suzuki, K., Wei, Y., Wang, Y., Blumenthal, R., Chen, Z., Falke, C., Zarate, C. A., & Manji, H. K. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301178 · Cited by 208 · see citing works

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

Schoepp, D. D., Wright, R. A., Levine, L. R., Gaydos, B. L., & Potter, W. Z. (2003) · Stress · doi:10.1080/1025389031000146773 · Cited by 207 · see citing works

Preliminary Evidence of Riluzole Efficacy in Antidepressant-Treated Patients with Residual Depressive Symptoms

Sanacora, G., Kendell, S. F., Levin, Y., Simen, A. A., Fenton, L. R., Coric, V., & Krystal, J. H. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.037 · Cited by 199 · see citing works

Adaptive changes in the N-methyl-D-aspartate receptor complex after chronic treatment with imipramine and 1-aminocyclopropanecarboxylic acid.

Nowak, G., Trullás, R., Layer, R. T., Skolnick, P., & Paul, I. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38235-2 · Cited by 196 · see citing works

Rapid Onset of Antidepressant Action: A New Paradigm in the Research and Treatment of Major Depressive Disorder

Machado-Vieira, R., Salvadore, G., Luckenbaugh, D. A., Manji, H. K., & Zarate, C. A. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0610 · Cited by 195 · cited 1× · see citing works

Riluzole enhances expression of brain‐derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus

Katoh, R., Asano, T., Ueda, H., Morishita, R., Takeuchi, I. K., Inaguma, Y., & Kato, K. (2002) · The FASEB Journal · doi:10.1096/fj.02-0143fje · Cited by 193 · see citing works

Association of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort

Paddock, S., Laje, G., Charney, D. S., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R. H., Wisniewski, S. R., Manji, H., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111790 · Cited by 192 · see citing works

Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

Mccullumsmith, R., & Meador-Woodruff, J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00370-0 · Cited by 189 · see citing works

Small-Dose Ketamine Improves the Postoperative State of Depressed Patients

Kudoh, A., Takahira, Y., Katagai, H., & Takazawa, T. (2002) · Anesthesia &amp; Analgesia · doi:10.1097/00000539-200207000-00020 · Cited by 189 · see citing works

Family History of Alcohol Dependence and Initial Antidepressant Response to an N-methyl-D-aspartate Antagonist

Phelps, L. E., Brutsché, N. E., Moral, J. R., Luckenbaugh, D. A., Manji, H. K., & Zarate, C. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.029 · Cited by 188 · see citing works

Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment

Horstmann, S., Lucae, S., Menke, A., Hennings, J. M., Ising, M., Roeske, D., Müller-Myhsok, B., Holsboer, F., & Binder, E. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.180 · Cited by 185 · see citing works

Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder

Clinton, S. M., & Meador‐Woodruff, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300451 · Cited by 177 · see citing works

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

Black, M. D. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2065-6 · Cited by 176 · see citing works

Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes

Azbill, R. D., Mu, X., & Springer, J. E. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02430-6 · Cited by 175 · see citing works

(R, S)-4-Phosphonophenylglycine, a Potent and Selective Group III Metabotropic Glutamate Receptor Agonist, Is Anticonvulsive and Neuroprotective In Vivo

Gasparini, F., Bruno, V., Battaglia, G., Lukic, S., Leonhardt, T., Inderbitzin, W., Laurie, D., Sommer, B., Varney, M. A., Hess, S. D., et al. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38321-1 · Cited by 174 · see citing works

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders

Machado-Vieira, R., Manji, H. K., & Zarate, C. A. (2009) · The Neuroscientist · doi:10.1177/1073858409336093 · Cited by 171 · see citing works

Enhanced anxiety, depressive‐like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1)

Tordera, R. M., Totterdell, S., Wojcik, S. M., Brose, N., Elizalde, N., Lasheras, B., & del Rı́o, J. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05259.x · Cited by 169 · see citing works

Rapid Enhancement of Glutamatergic Neurotransmission in Bipolar Depression Following Treatment with Riluzole

Brennan, B. P., Hudson, J. I., Jensen, J. E., McCarthy, J., Roberts, J. L., Prescot, A. P., Cohen, B. M., Pope, H. G., Renshaw, P. F., & Öngür, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.191 · Cited by 168 · see citing works

Association of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort

Ballenger, J. C. (2009) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)79086-8 · Cited by 167 · see citing works

DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signaling

Wilson, G. M., Flibotte, S., Chopra, V. S., Melnyk, B. L., Honer, W. G., & Holt, R. A. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi489 · Cited by 167 · see citing works

Regulation of Cellular Plasticity Cascades in the Pathophysiology and Treatment of Mood Disorders

Zarate, C. A., Du, J., Quiroz, J. A., GRAY, N. A., Denicoff, K. D., Singh, J., Charney, D. S., & Manji, H. K. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.017 · Cited by 164 · see citing works

Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice

Li, X., Need, A. B., Baez, M., & Witkin, J. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103143 · Cited by 163 · see citing works

Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder

McCullumsmith, R. E., Kristiansen, L. V., Beneyto, M., Scarr, E., Dean, B., & Meador‐Woodruff, J. H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.011 · Cited by 157 · see citing works

Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression

Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157 · see citing works

Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane

Moryl, E., Danysz, W., & Quack, G. (1993) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1993.tb01351.x · Cited by 157 · see citing works

Brain-Derived Neurotrophic Factor and Initial Antidepressant Response to an<i>N</i>-Methyl-<scp>D</scp>-Aspartate Antagonist

Machado-Vieira, R., Yuan, P., Brutsche, N., DiazGranados, N., Luckenbaugh, D., Manji, H. K., & Zarate, C. A. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04659 · Cited by 155 · see citing works

NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder

Toro, C. T., & Deakin, J. F. W. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.07.003 · Cited by 151 · see citing works

Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice

Mineur, Y. S., Picciotto, M. R., & Sanacora, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.037 · Cited by 150 · see citing works

The NR1 subunit of the glutamate/NMDA receptor in the superior temporal cortex in schizophrenia and affective disorders

Nudmamud‐Thanoi, S., & Reynolds, G. P. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.09.035 · Cited by 147 · see citing works

Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes

Mizuta, I., Ohta, M., Ohta, K., Nishimura, M., Mizuta, E., & Kuno, S. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02098-5 · Cited by 145 · see citing works

Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression

Karolewicz, B., Szebeni, K., Gilmore, T., Maciąg, D., Stockmeier, C. A., & Ordway, G. A. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008985 · Cited by 144 · see citing works

Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism

Petrakis, I. L., Limoncelli, D., Gueorguieva, R. V., Jatlow, P. L., Boutros, N. N., Trevisan, L. A., Gelernter, J. E., & Krystal, J. H. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1776 · Cited by 143 · see citing works

Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder

Meador‐Woodruff, J. H., Hogg, A. J., & Smith, R. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00523-8 · Cited by 141 · see citing works

Metabotropic Glutamate Receptors in the Control of Mood Disorders

Witkin, J. M., Marek, G. J., Johnson, B., & Schoepp, D. D. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363302 · Cited by 140 · see citing works

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

Pałucha-Poniewiera, A., Kłak, K., Brański, P., van der Putten, H., Flor, P. J., & Pilc, A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0856-2 · Cited by 139 · see citing works

AMPA receptor modulators as cognitive enhancers

LYNCH, G. S. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.09.009 · Cited by 138 · see citing works

N-methyl-d-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels

Martucci, L., Wong, A. H. C., Luca, V. D., Likhodi, O., Wong, G. W. H., King, N. A., & Kennedy, J. L. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.001 · Cited by 137 · see citing works

Open-Label Trial of Riluzole in Generalized Anxiety Disorder

Mathew, S. J., Amiel, J. M., Coplan, J. D., Fitterling, H. A., Sackeïm, H. A., & Gorman, J. M. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2379 · Cited by 134 · see citing works

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats

Pałucha-Poniewiera, A., Tatarczynska, E., Brański, P., Szewczyk, B., Wierońska, J. M., Kłak, K., Chojnacka-Wójcik, E., Nowak, G., & Pilc, A. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.09.006 · Cited by 132 · see citing works

Current perspectives on the development of non-biogenic amine-based antidepressants

Skolnick, P., Legutko, B., Li, X., & Bymaster, F. P. (2001) · Pharmacological Research · doi:10.1006/phrs.2000.0806 · Cited by 132 · see citing works

NMDA Receptor Antagonism and the Ethanol Intoxication Signal

Krystal, J. H., Petrakis, I. L., Krupitsky, E. M., Schütz, C., Trevisan, L. A., & D’Souza, D. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.010 · Cited by 132 · see citing works

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

Karasawa, J.-I., Shimazaki, T., Kawashima, N., & Chaki, S. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.032 · Cited by 131 · see citing works

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

Yoshimizu, T., Shimazaki, T., Ito, A., & Chaki, S. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0390-7 · Cited by 131 · see citing works

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder

Devon, R. S., Anderson, S., Teague, P. W., Burgess, P., Kipari, T. M. J., Semple, C. A. M., Millar, J. K., Muir, W. J., Murray, V., Pelosi, A. J., et al. (2001) · Psychiatric Genetics · doi:10.1097/00041444-200106000-00003 · Cited by 124 · see citing works

Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder

Scarr, E., Pavey, G., Sundram, S., Mackinnon, A. J., & Dean, B. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00024.x · Cited by 121 · see citing works

Roles and regulation of glutamate transporters in the central nervous system

O'Shea, R. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03770.x · Cited by 121 · see citing works

Age-related changes in the protein expression of subunits of the NMDA receptor

Magnusson, K. R., Nelson, S. E., & Young, A. B. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00344-8 · Cited by 120 · see citing works

Targeting Glutamatergic Signaling for the Development of Novel Therapeutics for Mood Disorders

Machado‐Vieira, R., Salvadore, G., Ibrahim, L. A., Diazgranados, N., & Zarate, C. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168010 · Cited by 117 · see citing works

Psychiatric safety of ketamine in psychopharmacology research

Perry, E. B., Cramer, J. A., Cho, H.-S., Petrakis, I. L., Karper, L. P., Genovese, A., O’Donnell, E., Krystal, J. H., D’Souza, D. C., & Yale Ketamine Study Group (2007) · Psychopharmacology · doi:10.1007/s00213-007-0706-2 · Cited by 117 · see citing works

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039

Yoshimizu, T., & Chaki, S. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.073 · Cited by 116 · see citing works

Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder

Pickard, B. S., Malloy, M. P., Christoforou, A., Thomson, P. A., Evans, K. L., Morris, S. W., Hampson, M. E., Porteous, D. J., Blackwood, D., & Muir, W. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001867 · Cited by 114 · see citing works

Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia

Beneyto, M., & Meador‐Woodruff, J. H. (2006) · Synapse · doi:10.1002/syn.20329 · Cited by 113 · see citing works

Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression

Kristiansen, L. V., & Meador‐Woodruff, J. H. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.06.012 · Cited by 106 · see citing works

Evidence that the N-methyl-D-aspartate subunit 1 receptor gene (GRIN1) confers susceptibility to bipolar disorder

Mundo, E., Tharmalingham, S., Neves-Pereira, M., Dalton, E. J., Macciardi, F. M., Parikh, S. V., Bolonna, A. A., Kerwin, R. W., Arranz, M. J., MAKOFF, A. J., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001218 · Cited by 105 · see citing works

Modulators of the Glutamatergic System: Implications for the Development of Improved Therapeutics in Mood Disorders

Zarate, C. A., Quiroz, J. A., Quiroz, J. A., Manji, H. K., Payne, J. L., Kornstein, S. G., Manji, A. H. K., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4204 · Cited by 104 · see citing works

Pro-survival signalling from the NMDA receptor

Hardingham, G. E. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340936 · Cited by 100 · see citing works

Regulation of Editing and Expression of Glutamate α-Amino-Propionic-Acid (AMPA)/Kainate Receptors by Antidepressant Drugs

Barbon, A., Popoli, M., Via, L. L., Moraschi, S., Vallini, I., Tardito, D., Tiraboschi, E., Musazzi, L., Giambelli, R., Gennarelli, M., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.018 · Cited by 93 · see citing works

Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population

Martí, S. B., Cichon, S., Propping, P., & Nöthen, M. M. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1624 · Cited by 90 · see citing works

Selective cortical VGLUT1 increase as a marker for antidepressant activity

Moutsimilli, L., Farley, S., Dumas, S., Mestikawy, S. E., Bruno Giros, A., & Tzavara, E. T. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.06.017 · Cited by 88 · see citing works

Metabolic Correlates of Antidepressant and Antipsychotic Response in Patients With Psychotic Depression Undergoing Electroconvulsive Therapy

McCormick, L. M., Ponto, L. L. B., Pierson, R. K., Johnson, H. J., Magnotta, V. A., & Brumm, M. C. (2007) · Journal of Ect · doi:10.1097/yct.0b013e318150d56d · Cited by 87 · see citing works

Excitatory Synaptic Transmission in the Lateral and Central Amygdala

Sah, P., & de Armentia, M. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07072.x · Cited by 86 · see citing works

Antidepressant Effect of Ketamine During ECT

Ostroff, R. B., GONZALES, M., & Sanacora, G. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.7.1385 · Cited by 82 · see citing works

Up‐regulation of hippocampal glutamate transport during chronic treatment with sodium valproate

Hassel, B., Iversen, E. G., Gjerstad, L., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00349.x · Cited by 82 · see citing works

Effects of the NMDA receptor antagonist ketamine on flavor memory: Conditioned aversion, latent inhibition, and habituation of neophobia

Aguado, L., Antonio, A. S., Pérez, L., del Valle, R., & Gómez, J. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80010-x · Cited by 80 · see citing works

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

Miu, P., Jarvie, K. R., Radhakrishnan, V., Gates, M. R., Ogden, A.-M., Ornstein, P. L., Zarrinmayeh, H., Ho, K. H., Peters, D., Grabell, J., et al. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00027-2 · Cited by 79 · see citing works

Decreased Glutamate/Glutamine Levels May Mediate Cytidine’s Efficacy in Treating Bipolar Depression: A Longitudinal Proton Magnetic Resonance Spectroscopy Study

Yoon, S. J., Lyoo, I. K., Haws, C. A., Kim, T. S., Cohen, B. M., & Renshaw, P. F. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.2 · Cited by 78 · see citing works

Intravenous ketamine therapy in a patient with a treatment-resistant major depression

Liebrenz, M., Borgeat, A., & Leisinger, R. (2007) · Swiss Medical Weekly · doi:10.4414/smw.2007.11852 · Cited by 75 · see citing works

Antidepressant-like effect of lamotrigine in the mouse forced swimming test: Evidence for the involvement of the noradrenergic system

Kaster, M. P., Raupp, I. M., Binfaré, R. W., Andreatini, R., & Rodrigues, A. L. S. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.003 · Cited by 73 · see citing works

Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder

Schiffer, H. H., & Heinemann, S. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30374 · Cited by 71 · see citing works

Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology

Quiroz, J. A., Singh, J. B., Gould, T. D., Denicoff, K. D., Zarate, C. A., & Manji, H. K. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001521 · Cited by 71 · see citing works

Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans

Itokawa, M., Yamada, K., Iwayama‐Shigeno, Y., Ishitsuka, Y., Detera‐Wadleigh, S. D., & Yoshikawa, T. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00501-9 · Cited by 70 · see citing works

Pre-treatment anterior cingulate activity as a predictor of antidepressant response to repetitive transcranial magnetic stimulation (rTMS).

Langguth, B., Wiegand, R., Kharraz, A., Landgrebe, M., Marienhagen, J., Frick, U., Hajak, G., & Eichhammer, P. (2007) · PubMed · Cited by 68 · see citing works

The schizophrenia ketamine challenge study debate.

Carpenter, W. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00194-8 · Cited by 67 · see citing works

Compartmentalized NMDA receptor signalling to survival and death

Soriano, F. X., & Hardingham, G. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.138875 · Cited by 65 · see citing works

Glia mechanisms in mood regulation: a novel model of mood disorders

Lee, Y., Gaskins, D. L., Anand, A., & Shekhar, A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0652-4 · Cited by 64 · see citing works

Inhibitors of the Glutamate Vesicular Transporter (VGLUT)

Thompson, C. M., Davis, E. S., Carrigan, C. N., et al. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867054637635 · Cited by 64 · see citing works

Rapid Relief of Severe Major Depressive Disorder by Use of Preoperative Ketamine and Electroconvulsive Therapy

Goforth, H. W., & Holsinger, T. (2007) · Journal of Ect · doi:10.1097/01.yct.0000263257.44539.23 · Cited by 63 · see citing works

Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment

Tordera, R. M., Pei, Q., & Sharp, T. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03192.x · Cited by 61 · see citing works

Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis

Ueda, Y., & Willmore, L. J. (2000) · Experimental Brain Research · doi:10.1007/s002210000443 · Cited by 61 · see citing works

Effects of intravenous caffeine administered to healthy males during sleep

Lin, A. S., Uhde, T. W., Slate, S. O., & McCann, U. D. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)5:1 · Cited by 59 · see citing works

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

Wierońska, J. M., Szewczyk, B., Brański, P., Pałucha-Poniewiera, A., & Pilc, A. (2002) · Amino Acids · doi:10.1007/s00726-001-0131-5 · Cited by 58 · see citing works

Reduced Sensitivity to Ketamine and Pentobarbital in Mice Lacking the N-Methyl-d-Aspartate Receptor GluRε1 Subunit

Petrenko, A. B., Yamakura, T., Fujiwara, N., Askalany, A. R., Baba, H., & Sakimura, K. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000131729.54986.30 · Cited by 53 · see citing works

Treating Neurodegenerative Diseases with Antibiotics

Miller, T. M., & Cleveland, D. W. (2005) · Science · doi:10.1126/science.1109027 · Cited by 52 · see citing works

Memantine Efficacy and Safety in Patients With Acute Mania Associated With Bipolar I Disorder

Keck, P. E., Hsu, H.-A., Papadakis, K., & Russo, J. (2009) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e318184fae2 · Cited by 51 · see citing works

Chronic Riluzole Treatment Increases Glucose Metabolism in Rat Prefrontal Cortex and Hippocampus

Chowdhury, G. M. I., Banasr, M., de Graaf, R. A., Rothman, D. L., Behar, K. L., & Sanacora, G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.78 · Cited by 48 · see citing works

Memantine may acutely improve cognition and have a mood stabilizing effect in treatment-resistant bipolar disorder

Teng, C. T., & Demétrio, F. N. (2006) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462006000300020 · Cited by 48 · see citing works

Ketamine blocks a conditioned taste aversion (CTA) in neonatal rats1

Mickley, G. A., Schaldach, M. A., Snyder, K. J., Balogh, S. A., Len, T., Neimanis, K., Goulis, P., Hug, J., Sauchak, K., Remmers-Roeber, D. R., et al. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00097-3 · Cited by 44 · see citing works

Selective NR1/2BN-Methyl- d -aspartate Receptor Antagonists among Indole-2-carboxamides and Benzimidazole-2-carboxamides

Borza, I., Bozó, É., BARTA‐SZALAI, G., Kiss, C., Tárkányi, G., Demeter, Á., Gáti, T., Háda, V., Kolok, S., Gere, A., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm060420k · Cited by 43 · see citing works

Antidepressant-like effect of lamotrigine is reversed by veratrine: A possible role of sodium channels in bipolar depression

Prica, C., Hascoët, M., & Bourin, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.007 · Cited by 43 · see citing works

Genetic Markers Within Glutamate Receptors Associated With Antidepressant Treatment-Emergent Suicidal Ideation

Menke, A., Lucae, S., Kloiber, S. M., Horstmann, S., Bettecken, T., Uhr, M., Ripke, S., Ising, M., Müller‐Myhsok, B., HOLSBOER, F., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08020274 · Cited by 37 · see citing works

Effect of Riluzole on MK-801 and Amphetamine-Induced Hyperlocomotion

da Silva, A. L., Hoffmann, A., Dietrich, M. O., Dall'Igna, O. P. P., Souza, D. O., & Lara, D. R. (2003) · Neuropsychobiology · doi:10.1159/000071825 · Cited by 34 · see citing works

Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons

Li, B., Zhang, S., Li, M., Zhang, H., Hertz, L., & Peng, L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.004 · Cited by 33 · see citing works

Lamotrigine in the treatment of bipolar disorder

Bhagwagar, Z., & Goodwin, G. M. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.8.1401 · Cited by 25 · see citing works

Magnetic Resonance Spectroscopy Studies of the Glutamatergic System in Mood Disorders: A Pathway to Diagnosis, Novel Therapeutics, and Personalized Medicine?

Salvadore, G., & Zarate, C. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.011 · Cited by 23 · see citing works

In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist

Suetake-Koga, S., Shimazaki, T., Takamori, K., Chaki, S., Kanuma, K., Sekiguchi, Y., Suzuki, T., Kikuchi, T., Matsui, Y., & Honda, T. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.04.018 · Cited by 23 · see citing works

Searching for Rational Anti–N-methyl-D-aspartate Treatment for Depression

Tsai, G. E. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.9.1099 · Cited by 18 · see citing works

Ketamine and amphetamine both enhance synaptic transmission in the amygdala–nucleus accumbens pathway but with different time‐courses

Kessal, K., Chessel, A., Spennato, G., & Garcia, R. (2005) · Synapse · doi:10.1002/syn.20154 · Cited by 16 · see citing works

Neuroprotective Agents: Is Effective on Toxicity in Glial Cells?

Dağcı, T., Yılmaz, Ö., Taşkıran, D., & Peker, G. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9082-4 · Cited by 14 · see citing works

Chronic imipramine treatment reduces inhibitory properties of group II mGlu receptors without affecting their density or affinity.

Pałucha-Poniewiera, A., Brański, P., Kłak, K., & Sowa-Kućma, M. (2007) · PubMed · Cited by 10 · see citing works

Palmitoylation of the p75 neurotrophin receptor has no effect on its interaction with TrkA or on TrkA-mediated down-regulation of cell adhesion molecules

Vesa, J., Kr�ttgen, A., Cosgaya, J. M., & Shooter, E. M. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 9 · see citing works

Searching for Rational Anti–N-methyl-D-aspartate Treatment forDepression—Reply

Zarate, C. A., Charney, D. S., & Manji, H. K. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.9.1100 · Cited by 6 · see citing works

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · see citing works

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

Yang, C., Shirayama, Y., Zhang, J.-C., Ren, Q., Yao, W., Ma, M., Dong, C., & Hashimoto, K. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.136 · Cited by 605 · see citing works

Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study

Ibrahim, L., DiazGranados, N., Franco-Chaves, J., Brutsche, N., Henter, I. D., Kronstein, P., Moaddel, R., Wainer, I., Luckenbaugh, D. A., Manji, H. K., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.338 · Cited by 309 · see citing works

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

Voleti, B., Navarria, A., Liu, R.-J., Banasr, M., Li, N., Terwilliger, R., Sanacora, G., Eid, T., Aghajanian, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.025 · Cited by 264 · see citing works

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

Searcy, J. L., Phelps, J. T., Pancani, T., Kadish, I., Popovic, J., Anderson, K. L., Beckett, T. L., Murphy, M. P., Chen, K.-C., Blalock, E. M., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111661 · Cited by 154 · see citing works

Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine’s Rapid Antidepressant Properties

Duncan, W. C., Slonena, E., Hejazi, N. S., Brutsche, N., Yu, K. C., Park, L., Ballard, E. D., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.011 · Cited by 93 · see citing works

Antidepressant Augmentation Using the<i>N</i>-Methyl-<scp>d</scp>-Aspartate Antagonist Memantine: A Randomized, Double-Blind, Placebo-Controlled Trial

Smith, E. G., Deligiannidis, K. M., Ulbricht, C. M., Landolin, C. S., Patel, J. K., & Rothschild, A. J. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08252 · Cited by 82 · see citing works

Ketamine, Sleep, and Depression: Current Status and New Questions

Duncan, W. C., & Zarate, C. A. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0394-z · Cited by 76 · see citing works

Antidepressant- and anticompulsive-like effects of purinergic receptor blockade: Involvement of nitric oxide

Pereira, V. S., Casarotto, P. C., Hiroaki-Sato, V. A., Sartim, A. G., Guimarães, F. S., & Joca, S. R. L. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.01.008 · Cited by 66 · see citing works

Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression

Vecera, C. M., C. Courtes, A., Jones, G., Soares, J. C., & Machado-Vieira, R. (2023) · Pharmaceuticals · doi:10.3390/ph16111572 · Cited by 48 · see citing works

Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology

Data-Franco, J., Singh, A., Popovic, D., Ashton, M., Berk, M., Vieta, E., Figueira, M. L., & Dean, O. M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.09.004 · Cited by 38 · see citing works

Are 24-hour motor activity patterns associated with continued rapid response to ketamine?

Duncan Jr, W. C., Slonena, E. E., Hejazi, N. S., Brutsche, N., Park, L. T., Henter, I. D., Ballard, E. D., & Zarate Jr, C. A. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s172089 · Cited by 17 · see citing works

Disturbance of the Glutamatergic System in Mood Disorders

Jun, C. S., Choi, Y., Lim, S. M., Bae, S., Hong, Y. S., Kim, J. E., & Lyoo, I. K. (2014) · Experimental Neurobiology · doi:10.5607/en.2014.23.1.28 · Cited by 118 · see citing works

Adverse childhood experiences associate to reduced glutamate levels in the hippocampus of patients affected by mood disorders

Poletti, S., Locatelli, C., Falini, A., Colombo, C., & Benedetti, F. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.007 · Cited by 21 · see citing works

Clinical features and pharmacotherapy of bipolar disorder

Li-l, S. (2010) · Clinical Medicine

Lithium in maintenance therapy for bipolar disorder

Young, A. H., & Newham, J. J. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806063072 · Cited by 44 · see citing works

Pharmacogenetics and mood stabilization in bipolar disorder

Růžičková, M., Turecki, G., & Alda, M. (2003) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.20010 · Cited by 7 · see citing works