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Effect of Anesthetics on Mitochondrial Function
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“Understanding the mechanism or mechanisms of ligand-GPCR interaction is particularly important due to the fact that GPCRs are a major drug target associated with one third of all pharmaceuticals 103,115 .”
From Quantum effects in the brain: A review (2020) · cites this paper as [103]
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Research works printed but not linked: 6
- [4]4. Berman MC, Kench JE: Biochemical features of malignant hyperthermia in Landrace pigs, International Symposium on Malignant Hyperthermia. Edited by RA Gordon, BA Britt, W Kalow. Springfield, Ill., Charles C Thomas, 1973, pp 287–297
- [12]12. Britt BA, Kalow W, Endrenyi L: Malignant hyperthermia and the mitochondria in human patients. International Symposium on Malignant Hyperthermia. Edited by RA Gordon, BA Britt, W Kalow. Springfield, Ill., Charles C Thomas, 1973, pp 387–398
- [14]14. Brucker RF, Williams CH, Popinigis J, et al: In vitro studies on liver mitochondria and skeletal muscle sarcoplasmic reticulum fragments isolated from hyperpyrexic swine, International Symposium on Malignant Hyperthermia. Edited by RA Gordon, BA Britt, W Kalow. Springfield, Ill., Charles C Thomas, 1973, pp 238–270.
- [26]26. Cohen PJ, Melntyre R: The effects of general anesthesia on respiratory control and oxygen consumption of rat liver mitochondria, e r r Be thetics. Edited by BR Fink. Baltimore, Williams and Wilkins, 1972, pp 109–116 - 2S. Denborough MA, Hird FJR, King JO, et al: Mitochondrial and other studies in Australian Landrace pigs affected with malignant hyperthermia, International Symposium on Malignant Hyperthermia. Édited by RA Gordon, BA Britt, W Kalow. Springfield, Ill., Charles C Thomas, 1973, pp 229-237.
- [53]53. Harrison GG: The effect of procaine and curare on the initiation of anaesthetic-induced malignant hyperpyrexia, International Symposium on Malignant Hyperthermia. Edited by RA Gordon, BA Britt, W Kalow. Springfieid, Ill., Charles C Thomas, 1973, Pp 271-286
- [78]78. Nahrwold ML, Cohen PJ: Additive effects of nitrous oxide and halothane on mitochondrial function. ANESTHESIOLOCY (in presS)
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Parikh, S., Goldstein, A., Koenig, M. K., Scaglia, F., Enns, G. M., Saneto, R., Anselm, I., Cohen, B. H., Falk, M. J., Greene, C., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2014.177 · Cited by 607
Comparison of the Effects of Bupivacaine and Ropivacaine on Heart Cell Mitochondrial Bioenergetics
Sztark, F., Malgat, M., Dabadie, P., et al. (1998) · Anesthesiology · doi:10.1097/00000542-199805000-00026 · Cited by 200
Kevin, L. G., Novalija, E., & Stowe, D. F. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000180999.81013.d0 · Cited by 197
“Studies by Cohen (122) in the 1970s, demonstrated that volatile anesthetics mildly depressed oxidative phosphorylation.”
BackgroundMitochondrial Expression and Function of GAS-1 in Caenorhabditis elegans
Kayser, E., Morgan, P. G., Hoppel, C. L., & Sedensky, M. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011066200 · Cited by 171
Anesthetic considerations in patients with mitochondrial defects
Niezgoda, J., & Morgan, P. G. (2013) · Pediatric Anesthesia · doi:10.1111/pan.12158 · Cited by 169
Metadata
- Authors
- Cohen, P. J.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Cohen, Peter J.
- Venue
- Anesthesiology
- Published
- 1973-08-01
- Volume
- 39
- Issue
- 2
- Pages
- 153-164
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W1996551678
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- anesthetic agents, mitochondrial function, mitochondrial dysfunction
- MeSH terms
- Anesthesia, Inhalation, Anesthetics, Animals, Barbiturates, Dogs, Electron Transport, Guinea Pigs, Halothane, Humans, Malignant Hyperthermia, Mitochondria, NAD, NADH, NADPH Oxidoreductases, Oxidative Phosphorylation, Oxygen Consumption, Succinate Dehydrogenase, Uncoupling Agents, Rats
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