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Effect of Anesthetics on Mitochondrial Function
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“Understanding the mechanism or mechanisms of ligand-GPCR interaction is particularly important due to the fact that GPCRs are a major drug target associated with one third of all pharmaceuticals 103,115 .”
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“Studies by Cohen (122) in the 1970s, demonstrated that volatile anesthetics mildly depressed oxidative phosphorylation.”
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“The primary effect of barbiturates on oxidative phosphorylation in mitochondria obtained from brain, heart, and liver also seems to be inhibition of complex I, and, like propofol, they seem to “uncouple “ metabolic activity from ATP production, further reducing bioenergetic capacity.(57) Inhalational anesthetic agents…”
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“, exposure of the heart to a volatile anesthetic followed by its washout, protects the heart against subsequent ischemia-reperfusion injury (3,6, 14, 18, 28, 35).”
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“General anesthetics may inhibit mitochondrial functions (Cohen, 1973; Branca et al., 1989; Mirö et al., 1999) and predominantly affect the tissues that are highly dependent on oxidative metabolism (Morgan et al., 2002).”
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Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I
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The Biochemical Basis of Anesthetic Toxicity
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Evidence for the role of calcium ions and mitochondria in the maintainance of anaesthesia in the rat
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“As barbiturates and propofol are known to depress mitochondrial function, it is important to have a malignant hyperthermia resource kit readily available if they are used.(7,8) Furthermore, propofol is associated with the risk of propofol infusion syndrome, which could worsen the lactic acidosis in patients with Leigh…”
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Metadata
- Authors
- Cohen, P. J.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Cohen, Peter J.
- Venue
- Anesthesiology
- Published
- 1973-08-01
- Volume
- 39
- Issue
- 2
- Pages
- 153-164
- ISSN
- 0003-3022 (ISSN-L)
- OpenAlex
- W1996551678
- Cited by
- 145
- References
- 0
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Anesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- anesthetic agents, mitochondrial function, mitochondrial dysfunction
- MeSH terms
- Anesthesia, Inhalation, Anesthetics, Animals, Barbiturates, Dogs, Electron Transport, Guinea Pigs, Halothane, Humans, Malignant Hyperthermia, Mitochondria, NAD, NADH, NADPH Oxidoreductases, Oxidative Phosphorylation, Oxygen Consumption, Succinate Dehydrogenase, Uncoupling Agents, Rats
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