The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Tumor Necrosis Factor and Wound Healing
Open accessAbstract
Tumor necrosis factor alpha (TNF), 1 to 500 ng in saline (PBS) or collagen, was applied to the wounds of normal and Adriamycin-impaired mice and wound disruption strength (WDS) and histology were examined. Also wounded mice were administered TNF 25 to 75 micrograms/kg IP daily and WDS was determined. Wound histology was examined 6 months after wounding and local TNF application. Local TNF 5 to 500 ng in PBS did not significantly affect WDS. Local TNF 5 to 50 ng in collagen increased WDS 33% to 65% in Adriamycin-impaired animals (p = 0.05 to p less than 0.02). Local TNF 50 to 500 ng in collagen increased WDS 23% to 49% in normal animals (p = 0.08 to p less than 0.01). Adriamycin-impaired animals demonstrated improved wound histology with local TNF in collagen. Systemic TNF did not significantly affect WDS. Local TNF in collagen did not induce histologic pathology at 6 months. TNF may modulate macrophage function and local TNF in collagen can improve WDS in normal and Adriamycin-impaired animals.
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“There are contradictory reports on the effects of locally applied TNFα on granulation tissue formation in skin wound healing,59,64,65 indicating there is no consensus on the effects of local TNFα application.”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [64]
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Cites
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Desmoulière, A., Redard, M., Darby, I. A., & Gabbiani, G. (1995) · Europe PMC (PubMed Central) · Cited by 1,185
Arnold, F., & West, D. C. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90034-j · Cited by 354
Growth factors in wound healing
Lawrence, W., & Diegelmann, R. F. (1994) · Clinics in Dermatology · doi:10.1016/0738-081x(94)90266-6 · Cited by 322
The Innate Immune System in Acute and Chronic Wounds
MacLeod, A. S., & Mansbridge, J. N. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0608 · Cited by 289
Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee
入江, 一., Uchiyama, E., & Iwaso, H. (2003) · The Knee · doi:10.1016/s0968-0160(02)00083-2 · Cited by 270
Metadata
- Authors
- MOONEY, D. P., OʼREILLY, M., & GAMELLI, R. L.
- Affiliations
- University of Vermont (US)
- ORCID
- MOONEY, DAVID P.
- Venue
- Annals of Surgery
- Published
- 1990-02
- Volume
- 211
- Issue
- 2
- Pages
- 124-129
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC1357954
- OpenAlex
- W1978738930
- Cited by
- 144
- References
- 20
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Keywords
- TNF-α, wound healing, adriamycin nephropathy, macrophage function, collagen matrix, wound histology
- MeSH terms
- Administration, Topical, Animals, Collagen, Doxorubicin, Granulation Tissue, Male, Mice, Inbred Strains, Random Allocation, Skin, Sodium Chloride, Tumor Necrosis Factor-alpha, Wound Healing, Mice
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