Cited by 144Wound Healing and TreatmentsLiver physiology and pathologyBurn Injury Management and Outcomes

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Tumor Necrosis Factor and Wound Healing

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MOONEY, DAVID P., OʼREILLY, MICHAEL, GAMELLI, RICHARD L.·1990·Annals of Surgery

DOI 10.1097/00000658-199002000-00002PMC PMC1357954

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Abstract

Tumor necrosis factor alpha (TNF), 1 to 500 ng in saline (PBS) or collagen, was applied to the wounds of normal and Adriamycin-impaired mice and wound disruption strength (WDS) and histology were examined. Also wounded mice were administered TNF 25 to 75 micrograms/kg IP daily and WDS was determined. Wound histology was examined 6 months after wounding and local TNF application. Local TNF 5 to 500 ng in PBS did not significantly affect WDS. Local TNF 5 to 50 ng in collagen increased WDS 33% to 65% in Adriamycin-impaired animals (p = 0.05 to p less than 0.02). Local TNF 50 to 500 ng in collagen increased WDS 23% to 49% in normal animals (p = 0.08 to p less than 0.01). Adriamycin-impaired animals demonstrated improved wound histology with local TNF in collagen. Systemic TNF did not significantly affect WDS. Local TNF in collagen did not induce histologic pathology at 6 months. TNF may modulate macrophage function and local TNF in collagen can improve WDS in normal and Adriamycin-impaired animals.

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Authors: MOONEY, D. P., OʼREILLY, M., & GAMELLI, R. L.
Affiliations: University of Vermont (US)
ORCID: MOONEY, DAVID P.
Venue: Annals of Surgery
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1990-02
Volume: 211
Issue: 2
Pages: 124-129
ISSN: 0003-4932 (ISSN-L)
DOI: 10.1097/00000658-199002000-00002
PMC: PMC1357954
OpenAlex: W1978738930
Cited by: 144
References: 20
Citations by year: 2025: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 3 · 2013: 6 · 2012: 7
FWCI: 8.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annals of Surgery (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
Keywords: TNF-α, wound healing, adriamycin nephropathy, macrophage function, collagen matrix, wound histology
MeSH terms: Administration, Topical, Animals, Collagen, Doxorubicin, Granulation Tissue, Male, Mice, Inbred Strains, Random Allocation, Skin, Sodium Chloride, Tumor Necrosis Factor-alpha, Wound Healing, Mice

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Tumor Necrosis Factor and Wound Healing

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