The Effect of Glucocorticoid Administration on Bacterial Translocation: Evidence for an Acquired Mucosal Immunodeficient State
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Adherence of bacteria to intestinal epithelial cells may be the crucial initiating event for translocation and is normally prevented by both specific (secretory IgA) and nonspecific (mucus, bacterial antagonism, desquamation) mucosal defense mechanisms. The purpose of this study was to examine the effect of dexamethasone administration on mucosal immunity; specifically bacterial adherence and IgA. Twenty Fischer rats were randomly assigned to two groups of 10 animals each. Group I received 0.5 mL saline injection intraperitoneally (IP); and group II, 0.8 mg/150 g body weight dexamethasone IP per day for 2 consecutive days. The cecum mesenteric lymph nodes, and bile were aseptically collected, and bacterial adherence, bacterial translocation, and IgA concentration were determined. Results indicate that, compared with saline-treated animals, dexamethasone-treated animals had a fall in IgA (54 +/- 24 versus 232 +/- 41 micrograms/mg protein), an increase in bacterial adherence (8.2 +/- 0.5 versus 3.4 +/- 0.6 cfu (log10)/g cecum), and an increased incidence of bacterial translocation to the mesenteric lymph nodes (60% versus 0%). These data suggest that glucocorticoids may promote bacterial translocation by impairment of mucosal IgA synthesis.
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Many daily therapies and interventions in intensive care increase intestinal permeability, bacterial translocation, and bacterial virulence.
“Many daily therapies and interventions in intensive care increase intestinal permeability (eg, nonsteroidal anti-inflammatory drugs109 and parenteral feeding55,82), bacterial translocation (eg, antibiotics,65 corticosteroids,110 and opiates111), and bacterial virulence (eg, opiates19 and catecholamines22,51).”
From The microbiome and critical illness (2016) · cites this paper as [110]
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- Authors
- ALVERDY, J., & AOYS, E.
- Affiliations
- University of Illinois Chicago (US)
- Venue
- Annals of Surgery
- Published
- 1991-12
- Volume
- 214
- Issue
- 6
- Pages
- 719-723
- ISSN
- 0003-4932 (ISSN-L)
- PMC
- PMC1358497
- OpenAlex
- W2066236615
- Cited by
- 94
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2012: 3
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Surgery (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- glucocorticoids, dexamethasone, bacterial translocation, secretory IgA, bacterial adhesion, intestinal mucosal immunity, mesenteric lymph nodes, cecum, bile, mucosal defense mechanisms, immunosuppression
- MeSH terms
- Animals, Bacterial Adhesion, Cecum, Dexamethasone, Female, Immunoglobulin A, Secretory, Intestinal Mucosa, Lymph Nodes, Mesentery, Rats, Inbred F344, Bacterial Physiological Phenomena, Rats
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