The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Better Model of Acute Pancreatitis for Evaluating Therapy
Open accessAbstract
Existing models of acute pancreatitis have limitations to studying novel therapy. Whereas some produce mild self-limited pancreatitis, others result in sudden necrotizing injury. The authors developed an improved model providing homogeneous moderately severe injury by superimposing secretory hyperstimulation on minimal intraductal bile acid exposure. Sprague-Dawley rats (n = 231) received low-pressure intraductal glycodeoxycholic acid (GDOC) at very low (5 or 10 mmol/L) concentrations followed by intravenous cerulein. Cerulein or GDOC alone caused only very mild inflammation. However, GDOC combined with cerulein was uniformly associated with more edema (p less than 0.0005), acinar necrosis (p less than 0.01), inflammation (p less than 0.006), and hemorrhage (p less than 0.01). Pancreatic injury was further increased and death was potentiated by increasing volume and duration of intraductal low-dose GDOC infusion. There was significant morphologic progression between 6 and 24 hours. The authors conclude that (1) combining minimal intraductal bile acid exposure with intravenous hyperstimulation produces homogeneous pancreatitis of intermediate severity that can be modulated at will; (2) the injury is progressive over at least 24 hours with finite mortality rate; (3) the model provides superior opportunity to study innovative therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue
Lampel, M., & Kern, H. F. (1977) · Virchows Archiv A Pathological Anatomy and Histology · doi:10.1007/bf00432156 · Cited by 570
Enzymes of Starch Degradation and Synthesis
Bernfeld, P. (1951) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470122570.ch7 · Cited by 568
Experimental Pancreatitis in the Rat: Sodium Taurocholate-Induced Acute Haemorrhagic Pancreatitis
Aho, H. J., Koskensalo, S. M.-L., & Nevalainen, T. J. (1980) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528009181493 · Cited by 366
Niederau, C., Ferrell, L. D., & Grendell, J. H. (1985) · Gastroenterology · doi:10.1016/s0016-5085(85)80079-2 · Cited by 327
Necrosectomy and postoperative local lavage in necrotizing pancreatitis
Beger, H. G., Büchler, M., Bittner, R., Block, S., Nevalainen, T., & Roscher, R. (1988) · Journal of British Surgery · doi:10.1002/bjs.1800750306 · Cited by 318
Lombardi, B., Estes, L. W., & Longnecker, D. S. (1975) · PubMed · Cited by 253
Experimental Pancreatitis in the Rat
AHO, H. J., & Nevalainen, T. J. (1980) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528009181494 · Cited by 87
Frey, C. F. (1979) · The American Journal of Surgery · doi:10.1016/0002-9610(79)90034-5 · Cited by 64
Cited by
Merza, M., Hartman, H., Rahman, M., Hwaiz, R., Zhang, E., Renström, E., Luo, L., Mörgelin, M., Regner, S., & Thorlacius, H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.026 · Cited by 273
Van felius, I. D., Akkermans, L. M. A., Bosscha, K., Verheem, A., Harmsen, W., Visser, M. R., & Gooszen, H. G. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00410.x · Cited by 134
Ma, X., Dong, X., Xu, Y., Ma, N., Wei, M., Xie, X., Lu, Y., Cao, W., Lu, G., & Li, W. (2022) · Antioxidants · doi:10.3390/antiox12010100 · Cited by 41
Piao, X., Liu, B., Guo, L., Meng, F., & Gao, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7085709 · Cited by 32
Metadata
- Authors
- SCHMIDT, J., RATTNER, D. W., LEWANDROWSKI, K., COMPTON, C. C., MANDAVILLI, U., KNOEFEL, W. T., & WARSHAW, A. L.
- Venue
- Annals of Surgery
- Published
- 1992-01
- Volume
- 215
- Issue
- 1
- Pages
- 44-56
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2063513460
- Cited by
- 870
- References
- 8
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Better Model of Acute Pancreatitis for Evaluating Therapy. https://app.cochat.ai/papers/10.1097/00000658-199201000-00007
- The paper
- SCHMIDT, J., RATTNER, D. W., LEWANDROWSKI, K., COMPTON, C. C., MANDAVILLI, U., KNOEFEL, W. T., & WARSHAW, A. L. (1992). A Better Model of Acute Pancreatitis for Evaluating Therapy. Annals of Surgery. https://doi.org/10.1097/00000658-199201000-00007
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
