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Cited by 134Pancreatitis Pathology and TreatmentGastrointestinal motility and disordersGallbladder and Bile Duct Disorders

Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis

Van felius, I. D., Akkermans, L. M. A., Bosscha, K., Verheem, A., Harmsen, W., Visser, M. R., Gooszen, H. G.·2003·Neurogastroenterology & Motility
DOI 10.1046/j.1365-2982.2003.00410.x
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Abstract

Abstract The objective of this study is to investigate the effects of an acute necrotizing pancreatitis (ANP), without biliary obstruction, on the migrating motor complex (MMC), small bowel bacterial overgrowth (SBBO), bacterial translocation (BT) and infection of the pancreas simultaneously. Rats were divided into four groups: mild pancreatitis, control, ANP and sham operated control. Jejunal myoelectrodes were used to measure MMCs. Blood, peritoneal fluid, bile, and abdominal organs were harvested for microbial culturing 72 h after induction of pancreatitis. The splenic portion of the pancreas was taken for histology. During ANP the MMC cycle length was significantly increased from 14.1 ± 0.2 to 22.4 ± 1.9 min (P < 0.05). The duodenum of ANP rats was in contrast with the other groups characterized by Enterobacteriacae (> 3 log 10 CFU g −1 in seven of 12 rats, P < 0.05). A positive correlation (r = 0.78, P < 0.01) existed between duodenal Gram‐negative and anaerobic flora and the MMC cycle. Correlation between MMC cycle length and BT to the pancreas was positive as well (r = 0.70, P < 0.01). A positive correlation (r = 0.85, P < 0.01) was found between the severity of pancreatitis and duodenal bacterial overgrowth. During ANP without biliary obstruction, the jejunal MMC is disturbed and consequently SBBO occurs. The correlation between the severity of pancreatitis, the disturbance of the MMC and SBBO suggests an important pathophysiological role of the proximal small bowel in the infection of pancreatic necrosis.

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  • A reduction in parasympathetically controlled intestinal transit has been associated with an increase in small intestinal bacterial overgrowth and bacterial translocation.

    “A reduction in parasympathetically controlled intestinal transit has been associated with an increase in small intestinal bacterial overgrowth and bacterial translocation (Van Felius et al., 2003).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Van Felius et al., 2003

  • Impaired intestinal transit caused by compromised migrating motor complexes is associated with bacterial overgrowth in the small intestine.

    “Impaired intestinal transit caused by compromised, migrating motor complexes (a motor pattern characteristic of the fasting state of the gastrointestinal tract that is under parasympathetic control), is associated with bacterial overgrowth in the small intestine.20”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [20]

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Authors
Van felius, I. D., Akkermans, L. M. A., Bosscha, K., Verheem, A., Harmsen, W., Visser, M. R., & Gooszen, H. G.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Akkermans, L. M. A.
ORCID
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2003-06
Volume
15
Issue
3
Pages
267-276
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1046/j.1365-2982.2003.00410.x
OpenAlex
W2019343717
Cited by
134
References
30
Citations by year
2026: 6 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
4.47
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
Keywords
acute necrotizing pancreatitis, migrating motor complex, small intestinal bacterial overgrowth, bacterial translocation, jejunal motility, Enterobacteriaceae, pancreatitis severity
MeSH terms
Animals, Ascitic Fluid, Bile, Blood, Gastrointestinal Motility, Intestine, Small, Male, Pancreas, Myoelectric Complex, Migrating, Bacterial Translocation, Pancreatitis, Acute Necrotizing, Models, Animal, Rats

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