The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity
Open accessAbstract
Forty critically ill surgical patients with documented infections were studied during their stay in an intensive care unit. Among these patients, 19 developed septic shock and 16 died, 9 of them from septic shock. Interleukin 1 beta (IL-1 beta), tumor necrosis factor (TNF alpha), and interleukin 6 (IL-6) were measured each day and every 1 or 2 hours when septic shock occurred. Although IL-1 beta was never found, TNF alpha was most often observed in the serum at a level under 100 pg/mL except during septic shock. During these acute episodes TNF alpha level reached several hundred pg/mL, but only for a few hours. In contrast, IL-6 was always increased in the serum of acutely ill patients (peak to 500,000 pg/mL). There was a direct correlation between IL-6 peak serum level and TNF alpha peak serum level during septic shock and between IL-6 serum level and temperature or C-reactive protein serum level. Moreover, IL-6 correlated well with APACHE II score, and the mortality rate increased significantly in the group of patients who presented with IL-6 serum level above 1000 pg/mL. Thus, IL-6 appears to be a good marker of severity during bacterial infection.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Cited by
Inflammatory Cytokines in the BAL of Patients With ARDS
Meduri, G. U., Kohler, G., Headley, S., Tolley, E., Stentz, F., & Postlethwaite, A. (1995) · Chest · doi:10.1378/chest.108.5.1303 · Cited by 695
Keh, D., Boehnke, T., Weber-Cartens, S., Schulz, C., Ahlers, O., Bercker, S., Volk, H.-D., Doecke, W.-D., Falke, K. J., & Gerlach, H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-446oc · Cited by 600
Al-Sadi, R., Ye, D., Boivin, M., Guo, S., Hashimi, M., Ereifej, L., & Ma, T. Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085345 · Cited by 280
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The role of interleukin-6 in glucose homeostasis and lipid metabolism
Lehrskov, L. L., & Christensen, R. H. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00747-2 · Cited by 114
Metadata
- Authors
- DAMA, P., LEDOUX, D., NYS, M., VRINDTS, Y., GROOTE, D. D., FRANCHIMONT, P., & LAMY, M.
- Venue
- Annals of Surgery
- Published
- 1992-04
- Volume
- 215
- Issue
- 4
- Pages
- 356-362
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2093799856
- Cited by
- 808
- References
- 3
- FWCI
- 23.83
- Type
- journal article
- Language
- en
- Open access
- green
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