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Cited by 32Clinical Nutrition and GastroenterologyImmune Response and InflammationAnimal Nutrition and Physiology

Impairment of mucosal immunity by parenteral nutrition: Depressed nasotracheal influenza-specific secretory IgA levels and transport in parenterally fed mice

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Renegar, Kathryn B., Kudsk, Kenneth A., Dewitt, R. Chance, Wu, Yong, King, Brock K.·2001·Annals of Surgery
DOI 10.1097/00000658-200101000-00019PMC PMC1421172
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Abstract

OBJECTIVE: To examine the effects on mucosal selective transport of polymeric IgA (pIgA) and the ability of exogenous pIgA to provide protection despite altered mucosal transport. SUMMARY BACKGROUND DATA: Parenteral nutrition significantly impairs established antipseudomonal immunity and IgA-mediated antiviral immunity in association with gut-associated lymphoid tissue mass atrophy. Lack of enteral feeding also induces mucosal effects. METHODS: After immunization, nasotracheal levels of influenza-specific IgA were measured in cannulated mice randomized to chow feeding or parenteral nutrition. Nonimmune animals were randomized to chow or total parenteral nutrition, and after 5 days of diet were given a mixture of two antiinfluenza monoclonal antibodies, pIgA and IgG. Four hours after injection, nasal washes were collected and influenza-specific antibody levels were determined by enzyme-linked immunosorbent assay to calculate the selective transport index of IgA relative to IgG. In the final experiment, immunized animals were randomized to chow or parenteral feeding, and after 5 days, parenterally fed animals received either normal mouse serum or antiviral pIgA before viral challenge. Viral shedding was measured at 42 hours after challenge. RESULTS: Parenteral nutrition significantly reduced virus-specific IgA in nasotracheal washes. Parenteral nutrition depressed the selective transport index, demonstrating impaired mucosal transport of pIgA. Parenterally fed animals given specific antiviral pIgA but not normal mouse serum eliminated virus from the airway and regained mucosal protection, demonstrating adequate residual transport for immunity if adequate pIgA is present. CONCLUSION: Although both decreased IgA production due to gut-associated lymphoid tissue atrophy and impaired mucosal transport occur when enteral feeding is not provided, residual transport can provide antiviral protection if exogenous antiviral pIgA is available. Production, rather than transport, may be the most important factor in maintaining established respiratory tract IgA-mediated immunity.

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  • These changes are associated with increased intestinal bacterial translocation and the loss of respiratory antiviral defenses in mice.

    “These changes are associated with increased intestinal bacterial translocation and the loss of respiratory antiviral defenses in mice (Renegar et al., 2001).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Renegar et al., 2001

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  1. [3]Pruitt KM, Rahemtulla B, Rahemtulla F, Russell MW. Innate humoral factors. In: Ogra PL, Mestecky J, Lamm ME, et al,eds. Mucosal Immunology, 2d ed. New York: Academic Press; 1999: 65–88.
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Authors
Renegar, K. B., Kudsk, K. A., Dewitt, R. C., Wu, Y., & King, B. K.
Affiliations
University of Tennessee Health Science Center (US)
Corresponding author
Kudsk, Kenneth A.
ORCID
Wu, Yong
Venue
Annals of Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-01
Volume
233
Issue
1
Pages
134-138
ISSN
0003-4932 (ISSN-L)
DOI
10.1097/00000658-200101000-00019
PMC
PMC1421172
OpenAlex
W2086628648
Cited by
32
References
20
Citations by year
2026: 1 · 2025: 2 · 2021: 1 · 2015: 1 · 2014: 2 · 2013: 3
FWCI
2.35
Type
journal article
Language
en
Open access
Locations
  • Annals of Surgery (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (R01GM053439, 5 R01 GM53439)
  • National Institute of Allergy and Infectious Diseases (AI01359)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords
parenteral nutrition, mucosal immunity, secretory IgA, polymeric IgA, influenza, lung immunity, viral shedding, enteral nutrition
MeSH terms
Analysis of Variance, Animals, Enzyme-Linked Immunosorbent Assay, Immunoglobulin A, Secretory, Male, Nasal Mucosa, Orthomyxoviridae Infections, Parenteral Nutrition, Trachea, Statistics, Nonparametric, Immunity, Mucosal, Mice

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