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Nonsteroidal Antiinflammatory Drugs and Breast Cancer
Abstract
We examined the association of nonsteroidal antiinflammatory drugs and breast cancer risk in a case-control study of 511 breast cancer patients and 1,534 population control subjects. The relative risk of breast cancer was reduced in women using these compounds at least 3 times per week for > or = 1 year [odds ratio (OR) = 0.66; 95% confidence interval (CI) = 0.52-0.83]. Odds ratios were similar for use of ibuprofen (0.57) or aspirin per se (0.69). Breast cancer risk declined with increasing exposure, and the greatest risk reduction (40%; odds ratio = 0.60; 95% CI = 0.40-0.91) occurred at the highest level of use (daily intake for > or = 5 years). These results indicate that nonsteroidal antiinflammatory drugs may have chemopreventive potential against the development of breast cancer.
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Nonsteroidal Anti-Inflammatory Drugs and Cancer Prevention
Baron, J. A., & Sandler, R. S. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.511 · Cited by 297
The role of local estrogen Biosynthesis in males and females
Simpson, E., Rubin, G., Clyne, C., Robertson, K., O’Donnell, L., Jones, M., & Davis, S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00254-x · Cited by 249
Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
Harris, R., Beebe, & Alshafie (2012) · Journal of Experimental Pharmacology · doi:10.2147/jep.s23826 · Cited by 43
Self-citation
Metadata
- Authors
- Harris, R. E., Namboodiri, K. K., & Farrar, W. B.
- Venue
- Epidemiology
- Published
- 1996-03
- Volume
- 7
- Issue
- 2
- Pages
- 203-205
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W1964246992
- Cited by
- 345
- References
- 0
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
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