The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Municipal Drinking Water Nitrate Level and Cancer Risk in Older Women: The Iowa Women’s Health Study
Abstract
Nitrate contamination of drinking water may increase cancer risk, because nitrate is endogenously reduced to nitrite and subsequent nitrosation reactions give rise to N-nitroso compounds; these compounds are highly carcinogenic and can act systemically. We analyzed cancer incidence in a cohort of 21,977 Iowa women who were 55-69 years of age at baseline in 1986 and had used the same water supply more than 10 years (87% > 20 years); 16,541 of these women were on a municipal supply, and the remainder used a private well. We assessed nitrate exposure from 1955 through 1988 using public databases for municipal water supplies in Iowa (quartile cutpoints: 0.36, 1.01, and 2.46 mg per liter nitrate-nitrogen). As no individual water consumption data were available, we assigned each woman an average level of exposure calculated on a community basis; no nitrate data were available for women using private wells. Cancer incidence (N = 3,150 cases) from 1986 through 1998 was determined by linkage to the Iowa Cancer Registry. For all cancers, there was no association with increasing nitrate in drinking water, nor were there clear and consistent associations for non-Hodgkin lymphoma; leukemia; melanoma; or cancers of the colon, breast, lung, pancreas, or kidney. There were positive associations for bladder cancer [relative risks (RRs) across nitrate quartiles = 1, 1.69, 1.10, and 2.83] and ovarian cancer (RR = 1, 1.52, 1.81, and 1.84), and inverse associations for uterine cancer (RR = 1, 0.86, 0.86, and 0.55) and rectal cancer (RR = 1, 0.72, 0.95, and 0.47) after adjustment for a variety of cancer risk/protective factors, agents that affect nitrosation (smoking, vitamin C, and vitamin E intake), dietary nitrate, and water source. Similar results were obtained when analyses were restricted to nitrate level in drinking water from 1955 through 1964. The positive association for bladder cancer is consistent with some previous data; the associations for ovarian, uterine, and rectal cancer were unexpected.
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Drinking Water Nitrate and Human Health: An Updated Review
Ward, M., Jones, R., Brender, J., De Kok, T., Weyer, P., Nolan, B., Villanueva, C., & Van Breda, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15071557 · Cited by 1,576
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Ward, M. H., Kilfoy, B. A., Weyer, P. J., Anderson, K. E., Folsom, A. R., & Cerhan, J. R. (2010) · Epidemiology · doi:10.1097/ede.0b013e3181d6201d · Cited by 359
Self-citationNitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits
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Re‐evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives
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Meat and components of meat and the risk of bladder cancer in the NIH-AARP diet and health study
Ferrucci, L. M., Sinha, R., Ward, M. H., Graubard, B. I., Hollenbeck, A. R., Kilfoy, B. A., Schatzkin, A., Michaud, D. S., & Cross, A. J. (2010) · Cancer · doi:10.1002/cncr.25463 · Cited by 103
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Risk of Non-Hodgkin Lymphoma and Nitrate and Nitrite From Drinking Water and Diet
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Self-citationNitrate in public water supplies and the risk of renal cell carcinoma
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Self-citationEnhanced in situ denitrification for a municipal well
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Metadata
- Authors
- Weyer, P. J., Cerhan, J. R., Kross, B. C., Hallberg, G. R., Kantamneni, J., Breuer, G., Jones, M. P., Zheng, W., & Lynch, C. F.
- Venue
- Epidemiology
- Published
- 2001-05
- Volume
- 12
- Issue
- 3
- Pages
- 327-338
- ISSN
- 1044-3983 (ISSN-L)
- OpenAlex
- W2021045935
- Cited by
- 453
- References
- 4
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
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