Vomeronasal epithelial cells of the adult human express neuron-specific molecules
Abstract
Immunohistochemical localization of three molecular markers, neuron-specific enolase (NSE) and protein gene product (PGP) 9.5 for neurons and neuroendocrine cells, and olfactory marker protein (OMP) for olfactory receptor neurons (ORNs) was investigated in the vomeronasal epithelium (VNE) of adult humans. NSE- and PGP 9.5-immunoreactive cells were identified in the VNE. ORNs in the olfactory epithelium of approximately age-matched controls were immunoreactive for the three markers. Most NSE-immunoreactive cells in the VNE were bipolar and similar in shape to the NSE- and PGP 9.5-immunoreactive ORNs. The results indicate that the adult human VNE contains cells expressing two molecular markers characteristic of neurons and that these cells bear a striking morphological similarity to ORNs.
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The number of such NSE-staining cells is small: ~4 per 100 μm epithelial surface or less.
“It is clear from both reports that the number of such cells is small: ~4 per 100 µm epithelial surface (Takami et al., 1993) or less (Trotier et al., 2000).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Takami et al., 1993
Takami et al. and Trotier et al. found neuron-specific enolase (NSE) staining in these cells.
“Takami et al. and Trotier et al. found neuron-specific enolase (NSE) staining in these cells (Takami et al., 1993;Trotier et al., 2000).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Takami et al., 1993
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- Authors
- Takami, S., Getchell, M. L., Chen, Y., Monti-Bloch, L., Berliner, D. L., Stensaas, L. J., & Getchell, T. V.
- Affiliations
- University of Kentucky (US)
- ORCID
- Chen, Ying
- Venue
- NeuroReport
- Published
- 1993-04
- Volume
- 4
- Issue
- 4
- Pages
- 375-378
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2020731527
- Cited by
- 76
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2018: 1 · 2015: 1 · 2014: 2 · 2013: 2
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dc001715-04)
- National Institute on Aging (P50AG005144)
- National Institute on Deafness and Other Communication Disorders (NIDCD 00159, NIDCD-01715)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- vomeronasal epithelium, neuron-specific enolase, PGP 9.5, olfactory marker protein, olfactory sensory neurons, neuroendocrine cells, neuronal markers, bipolar cells, adults, olfactory epithelium
- MeSH terms
- Adult, Aged, Aged, 80 and over, Epithelium, Humans, Immunohistochemistry, Middle Aged, Nasal Septum, Nerve Tissue Proteins, Neurons, Phosphopyruvate Hydratase, Thiolester Hydrolases, Biomarkers, Ubiquitin Thiolesterase, Olfactory Marker Protein
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