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Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally
Abstract
Peripheral and central injections of recombinant rat interleukin-1 beta (IL-1 beta) have been shown to decrease social exploration in rats. To test the involvement of vagal afferents in the communication between the immune system and the brain, sham-operated and vagotomized rats were injected peripherally or centrally with physiological saline or IL-1 beta 4 weeks after surgery. Vagotomy attenuated the depression in social exploration induced by i.p. administration of IL-1 beta (15 micrograms) but did not alter the behaviour-depressing effects of an intracerebroventricular (i.c.v.) injection of IL-1 beta (45 ng). These results confirm the role of vagal afferent nerves in the transmission of an immune message from the periphery to the brain, and show that vagotomy does not impair the direct sensitivity of the brain itself to immune signals.
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“Preclinical studies of neural communication between the CNS and the peripheral immune system have targeted the vagus nerve, and demonstrate that vagotomy (sub-diaphragmatic transection of the vagus nerve) blocks or alters the dynamics of peripheral immune system communication to the CNS”
From Sleep health: Reciprocal regulation of sleep and innate immunity (2017) · cites this paper as Bluthe et al, 1996
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Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862
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Dantzer, R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05827.x · Cited by 825
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Dantzer, R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.002 · Cited by 789
“Sickness behavior also was abrogated in vagotomized animals injected with LPS or IL-1β [10], [11], [12].”
BackgroundSelf-citation
Metadata
- Authors
- Bluthe, R.-M., Michaud, B., Kelley, K. W., & Dantzer, R.
- Affiliations
- Inserm (FR)
- University of Illinois Urbana-Champaign (US)
- ORCID
- Dantzer, Robert
- Venue
- NeuroReport
- Published
- 1996-06
- Volume
- 7
- Issue
- 9
- Pages
- 1485-1488
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2004070779
- Cited by
- 158
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH051569, MH-51569-01A2)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- vagotomy, IL-1β, vagal afferents, social exploration, neuroimmune interactions, intracerebroventricular administration, vagus nerve
- MeSH terms
- Analysis of Variance, Animals, Appetite Depressants, Cholecystokinin, Exploratory Behavior, Injections, Intraperitoneal, Injections, Intraventricular, Interleukin-1, Male, Random Allocation, Social Behavior, Vagotomy, Vagus Nerve, Rats, Wistar, Rats
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