Cited by 159Vagus Nerve Stimulation ResearchTryptophan and brain disordersStress Responses and Cortisol

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Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally

Bluthe, Rose-Marie, Michaud, Bruno, Kelley, Keith W., Dantzer, Robert·1996·NeuroReport

DOI 10.1097/00001756-199606170-00008

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Abstract

Peripheral and central injections of recombinant rat interleukin-1 beta (IL-1 beta) have been shown to decrease social exploration in rats. To test the involvement of vagal afferents in the communication between the immune system and the brain, sham-operated and vagotomized rats were injected peripherally or centrally with physiological saline or IL-1 beta 4 weeks after surgery. Vagotomy attenuated the depression in social exploration induced by i.p. administration of IL-1 beta (15 micrograms) but did not alter the behaviour-depressing effects of an intracerebroventricular (i.c.v.) injection of IL-1 beta (45 ng). These results confirm the role of vagal afferent nerves in the transmission of an immune message from the periphery to the brain, and show that vagotomy does not impair the direct sensitivity of the brain itself to immune signals.

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Authors: Bluthe, R.-M., Michaud, B., Kelley, K. W., & Dantzer, R.
Affiliations: Inserm (FR)
University of Illinois Urbana-Champaign (US)
ORCID: Dantzer, Robert
Venue: NeuroReport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-06
Volume: 7
Issue: 9
Pages: 1485-1488
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/00001756-199606170-00008
OpenAlex: W2004070779
Cited by: 158
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 9
FWCI: 6.04
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Institute of Mental Health (R01MH051569, MH-51569-01A2)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: vagotomy, IL-1β, vagal afferents, social exploration, neuroimmune interactions, intracerebroventricular administration, vagus nerve
MeSH terms: Analysis of Variance, Animals, Appetite Depressants, Cholecystokinin, Exploratory Behavior, Injections, Intraperitoneal, Injections, Intraventricular, Interleukin-1, Male, Random Allocation, Social Behavior, Vagotomy, Vagus Nerve, Rats, Wistar, Rats

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Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally

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