Cited by 161Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

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Localization of leptin receptor mRNA expression in mouse brain

Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., Storlien, L.·1996·NeuroReport

DOI 10.1097/00001756-199611040-00045

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Abstract

The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in the dentate gyrus and CA1, and was detected at low levels in piriform cortex and the medial margin of the medial habenular nucleus. The localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptor is expressed on neuropeptide Y-containing neurones.

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Background
RAPID COMMUNICATION Absence of leptin expression and secretion by human luteinized granulosa cells
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“High concentrations of leptin receptors have been found in the brain, including within the hippocampus, attesting to the hormone’s central as well as peripheral sites of action beyond regulating adiposity [7].”
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Self-citation
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Untitled work
Merchenthaler (1999) · doi:10.1002/(sici)1096-9861(19990111)403:2

Authors: Huang, X. F., Koutcherov, I., Lin, S., Wang, H. Q., & Storlien, L.
Affiliations: University of Wollongong (AU)
ORCID: Huang, X. F.
Lin, S.
Venue: NeuroReport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-11
Volume: 7
Issue: 15
Pages: 2635-2638
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/00001756-199611040-00045
OpenAlex: W2061211669
Cited by: 160
References: 0
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 7 · 2014: 10 · 2013: 2 · 2012: 9
FWCI: 2.42
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: leptin receptor, mRNA expression, brain localization, hypothalamus, arcuate nucleus, median eminence, hippocampus, dentate gyrus, CA1, piriform cortex, medial habenula, neuropeptide Y neurons, C57 mice
MeSH terms: Animals, Base Sequence, Brain, Carrier Proteins, Female, Male, Mice, Inbred C57BL, Molecular Sequence Data, Receptors, Cell Surface, In Situ Hybridization, Mice, Receptors, Leptin

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Localization of leptin receptor mRNA expression in mouse brain

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