Mitochondrial function impairment induced by amyloid β-peptide on PC12 cells
Abstract
The aim of the present study was to determine whether amyloid beta-peptide (A beta) induces mitochondrial dysfunction. Mitochondrial function was reported to be affected following A beta exposure, as demonstrated by depolarization of the mitochondrial membrane, decrease of oxygen consumption and by the inhibition of complexes I, III and IV of the mitochondrial respiratory chain. A beta25-35 and A beta1-40 peptides also inhibited MTT reduction in a dose-dependent manner in undifferentiated and differentiated PC12 cells. Several antioxidants prevented this inhibitory response, suggesting that oxidative stress is involved in A beta-induced cytotoxicity. These data suggest that mitochondrial dysfunction contributes to amyloid beta-protein cytotoxicity and may play a major role in the abnormalities of energy metabolism observed in Alzheimer's disease.
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Clinical studies showed that increased levels of plasma Aβ40, but not Aβ42, significantly correlate with a heightened risk of AD.
“Also, clinical studies showed that increased levels of plasma Aβ40, but not Aβ42, significantly correlate with a heightened risk of AD (51,52, 53,54).”
From Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity (2025) · cites this paper as [53]
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- Authors
- Pereira, C., Santos, M. S., & Oliveira, C.
- Affiliations
- University of Coimbra (PT)
- Venue
- NeuroReport
- Published
- 1998-06
- Volume
- 9
- Issue
- 8
- Pages
- 1749-1755
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1999676188
- Cited by
- 115
- References
- 0
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 6
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- amyloid-beta, mitochondrial dysfunction, PC12 cells, oxidative stress, mitochondrial depolarization, oxygen consumption, respiratory chain complexes, cytotoxicity, antioxidants, Alzheimer's disease, energy metabolism
- MeSH terms
- Animals, Antioxidants, Cell Differentiation, Cell Survival, Membrane Potentials, Mitochondria, Peptide Fragments, Logistic Models, Amyloid beta-Peptides, PC12 Cells, Rats
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