Regeneration of a transected peripheral nerve by transplantation of spinal cord encapsulated in a vein
Abstract
The objective was to investigate the regeneration of a transected peripheral nerve after transplantation of fragmented embryonic (E14-15) spinal cord cells which were encapsulated within a vein cavity. After 3 months transplantation, axonal regeneration was observed by staining with HE and antibody to neurofilament subtypes in six of 10 rats. In all six animals compound muscle action potentials to electrical stimulation could be recorded and indicated incomplete reinnervation of the fibular and tibial nerve, respectively. A chronic inflammation process around the transplant and a negative result of staining neurofilaments within the vein cavity and the transected nerve were found in animals lacking electrophysiological response to stimulation.
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An animal model for a biohybrid approach to cure flaccid paralysis involves transplanting embryonic spinal cord cells into a container adapted to the distal nerve stump to restore skeletal muscle function.
“researchers have developed an animal model for a biohybrid approach to cure flaccid paralysis that involves embryonic spinal cord cell transplantation into a container adapted to the distal nerve stump to restore skeletal muscle function (Katsuki et al., 1997; Thomas et al., 2000; Klinge et al., 2001b)”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Klinge et al., 2001b
The presence of a polyimide-based regenerative electrode showed no chronic foreign body response, and the immunohistochemically measured pattern of characteristic proteins was comparable with a healing reaction without any implant.
“The presence of a polyimide-based regenerative electrode showed no chronic foreign body response, and the immunohistochemically measured pattern of characteristic proteins was comparable with a healing reaction without any implant (Klinge et al., 2001a) .”
From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Klinge et al., 2001a
Cites
Stieglitz, T., Beutel, H., & Meyer, J.-U. (1997) · Sensors and Actuators A: Physical · doi:10.1016/s0924-4247(97)01494-5 · Cited by 125 · see citing works
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Navarro, X., Krueger, T. B., Lago, N., Micera, S., Stieglitz, T., & Dario, P. (2005) · Journal of the Peripheral Nervous System · doi:10.1111/j.1085-9489.2005.10303.x · Cited by 845 · see citing works
- Authors
- Klinge, P. M., Groos, S., Wewetzer, K., Haastert, K., Rosahl, S., Vafa, M. A., Hosseini, H., Samii, M., & Brinker, T.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- International Neuroscience Institute (DE)
- Venue
- Neuroreport
- Published
- 2001-05
- Volume
- 12
- Issue
- 6
- Pages
- 1271-1275
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2088439061
- Cited by
- 10
- References
- 1
- Citations by year
- 2015: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- peripheral nerve regeneration, nerve transection, spinal cord transplantation, axon regeneration, reinnervation, compound muscle action potential, chronic inflammation, peroneal nerve, tibial nerve
- MeSH terms
- Action Potentials, Animals, Axons, Electric Stimulation, Embryo, Mammalian, Female, Femoral Vein, Nerve Regeneration, Peripheral Nerves, Sciatic Nerve, Spinal Cord, Rats, Sprague-Dawley, Muscle, Skeletal, Rats
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