Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes
Abstract
The basalo-cortical cholinergic system was characterized in mice expressing mutant human genes for presenilin-1 (PS1), amyloid precursor protein (APP), and combined PS/APP. Dual immunocytochemistry for ChAT and A beta revealed swollen cholinergic processes within cortical plaques in both APP and PS/APP brains by 12 months, suggesting aberrant sprouting or redistribution of cholinergic processes in response to amyloid deposition. At 8 months, cortical and subcortical ChAT activity was normal (PS/APP) or elevated (PS, APP frontal cortex), while cholinergic cell counts (nBM/SI) and receptor binding were unchanged. ChAT mRNA was up-regulated in the nBM/SI of all three transgenic lines at 8 months. The data indicate that the basal forebrain cholinergic system does not degenerate in mice expressing AD-related transgenes, even in mice with extreme amyloid load. The
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Overexpression of mutant APP or mutant PS1, but not their combined overexpression, elevates cortical ChAT activity.
“For example, overexpression of mutant APP or mutant PS1, but not their combined overexpression, elevates cortical ChAT activity (62).”
From Amyloid precursor protein-induced axonopathies are independent of amyloid-β peptides (2008) · cites this paper as [62]
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- Authors
- Hernandez, D., Sugaya, K., Qu, T., McGowan, E., Duff, K., & McKinney, M.
- Affiliations
- Mayo Clinic in Florida (US)
- Mayo Clinic (US)
- Venue
- Neuroreport
- Published
- 2001-05
- Volume
- 12
- Issue
- 7
- Pages
- 1377-1384
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2023848329
- Cited by
- 73
- References
- 4
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1 · 2018: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG09973, AG17585, P01AG009973)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- basal forebrain cholinergic system, presenilin 1, amyloid precursor protein, choline acetyltransferase, amyloid-beta
- MeSH terms
- Acetylcholine, Aging, Alzheimer Disease, Animals, Cell Count, Cell Survival, Cerebral Cortex, Choline O-Acetyltransferase, Cholinergic Fibers, Immunohistochemistry, Membrane Proteins, Mice, Transgenic, Nerve Degeneration, Neuronal Plasticity, Radioligand Assay, Receptors, Muscarinic, Receptors, Nicotinic, RNA, Messenger, Up-Regulation, Amyloid beta-Protein Precursor, Basal Nucleus of Meynert, Mice, Presenilin-1, Plaque, Amyloid
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