The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Lipoic acid improves survival in transgenic mouse models of Huntington's disease
Abstract
There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha-Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha-lipoic acid might have beneficial effects in HD patients.
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“We found that α-lipoic acid exerts significant neuroprotective effects in transgenic mouse models of HD and ALS128, 187, 188.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [187]
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Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073
Nucifora, F. C., Sasaki, M., Peters, M. F., Huang, H., Cooper, J. K., Yamada, M., Takahashi, H., Tsuji, S., Troncoso, J. C., Dawson, V. L., et al. (2001) · Science · doi:10.1126/science.1056784 · Cited by 1,112
Schilling, G. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.3.397 · Cited by 772
Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Packer, L., Tritschler, H. J., & Wessel, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00269-9 · Cited by 639
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522
Self-citationLength-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse
Wheeler, V. C. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.115 · Cited by 395
Involvement of Free Radicals in Excitotoxicity In Vivo
Schulz, J. B., Henshaw, D. R., Siwek, D. F., Jenkins, B. G., Ferrante, R. J., Cipolloni, P. B., Kowall, N. W., Rosen, B. R., & Beal, M. F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64052239.x · Cited by 322
Self-citationHagen, T. M., Ingersoll, R. T., Lykkesfeldt, J., Liu, J., Wehr, C. M., Vinarsky, V., Bartholomew, J. C., & Ames, B. N. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.2.411 · Cited by 292
Marangon, K., Devaraj, S., Tirosh, O., Packer, L., & Jialal, I. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00155-0 · Cited by 183
α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats
Panigrahi, M., Sadguna, Y., Shivakumar, B. R., Kolluri, S. V. R., Roy, S., Packer, L., & Ravindranath, V. (1996) · Brain Research · doi:10.1016/0006-8993(96)00009-1 · Cited by 176
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- Arivazhagan, 2001, J Nutr Sci, 12, 2
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Mitochondrial Approaches for Neuroprotection
Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294
Self-citationBioenergetic approaches for neuroprotection in Parkinson's disease
Beal, M. F. (2003) · Annals of Neurology · doi:10.1002/ana.10479 · Cited by 236
Self-citationDedeoglu, A., Kubilus, J. K., Yang, L., Ferrante, K. L., Hersch, S. M., Beal, M. F., & Ferrante, A. R. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01706.x · Cited by 169
Self-citationAcetyl-L-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?
Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Z., & McIntyre, R. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.6.827 · Cited by 23
Metadata
- Authors
- Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., & Beal, M. F.
- Affiliations
- Boston University (US)
- Venue
- Neuroreport
- Published
- 2001-10
- Volume
- 12
- Issue
- 15
- Pages
- 3371-3373
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2022851867
- Cited by
- 115
- References
- 23
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 7
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 12992, AG 14390, P01AG012992)
- National Institute of Neurological Disorders and Stroke (NS38180)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Huntington's disease, alpha-lipoic acid, antioxidants, neuroprotection, survival, R6/2 transgenic mice, excitotoxicity, oxidative damage
- MeSH terms
- Animals, Antioxidants, Benzenesulfonates, Body Weight, Brain, Disease Models, Animal, Food, Formulated, Huntington Disease, Thioctic Acid, Male, Mice, Transgenic, Survival, Treatment Outcome, Oxidative Stress, Neuroprotective Agents, Mice
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