Bioenergetic approaches for neuroprotection in Parkinson's disease

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

Mitochondrial Complex I Deficiency in Parkinson's Disease

Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., & Marsden, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb02325.x · Cited by 2,283 · see citing works

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260 · see citing works

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061 · see citing works

A Fraction of Yeast Cu,Zn-Superoxide Dismutase and Its Metallochaperone, CCS, Localize to the Intermembrane Space of Mitochondria

Sturtz, L. A., Diekert, K., Jensen, L. T., Lill, R., & Culotta, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105296200 · Cited by 719 · see citing works

The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living

Gorell, J., Johnson, C. C., Rybicki, B., Peterson, E., & Richardson, R. (1998) · Neurology · doi:10.1212/wnl.50.5.1346 · Cited by 694 · see citing works

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682 · see citing works

Origin and functional consequences of the complex I defect in Parkinson's disease

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638 · see citing works

Experimental models of Parkinson's disease

Beal, M. F. (2001) · Nature reviews. Neuroscience · doi:10.1038/35072550 · Cited by 634 · see citing works

ΔΨ _m ‐Dependent and ‐independent production of reactive oxygen species by rat brain mitochondria

Votyakova, T. V., & Reynolds, I. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00548.x · Cited by 601 · see citing works

Coenzyme Q ₁₀ administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557 · see citing works

Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease

Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522 · see citing works

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- l -carnitine and/or R -α-lipoic acid

Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504 · see citing works

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

Haas, R. H., Nasirian, F., Nakano, K., Ward, D., Pay, M., Hill, R., & Shults, C. W. (1995) · Annals of Neurology · doi:10.1002/ana.410370604 · Cited by 435 · see citing works

Possible environmental, occupational, and other etiologic factors for Parkinson's disease

Seidler, A., Hellenbrand, W., Robra, B., Vieregge, P., NISCHAN, P., Joerg, J., Oertel, W. H., Ulm, G., & Schneider, E. (1996) · Neurology · doi:10.1212/wnl.46.5.1275 · Cited by 433 · see citing works

Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease

Matthews, R. T., Yang, L., Jenkins, B. G., Ferrante, R. J., Rosen, B. R., Kaddurah-Daouk, R. F., & Beal, M. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00156.1998 · Cited by 431 · see citing works

Energy metabolism defects in Huntington's disease and effects of coenzyme Q₁₀

Koroshetz, W. J., Jenkins, B. G., Rosen, B. R., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410410206 · Cited by 405 · see citing works

Therapeutic Effects of Coenzyme Q₁₀and Remacemide in Transgenic Mouse Models of Huntington's Disease

Ferrante, R. J., Andreassen, O. A., Dedeoglu, A., Ferrante, K. L., Jenkins, B. G., Hersch, S. M., & Beal, M. F. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01592.2002 · Cited by 391 · see citing works

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

Mandir, A. S., Przedborski, S., Jackson-Lewis, V., Wang, Z.-Q., Simbulan-Rosenthal, C. M., Smulson, M. E., Hoffman, B. E., Guastella, D. B., Dawson, V. L., & Dawson, T. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5774 · Cited by 382 · see citing works

Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity

Matthews, R. T., Ferrante, R. J., Klivènyi, P., Yang, L., Klein, A., Mueller, G., Kaddurah-Daouk, R. F., & Beal, M. F. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7049 · Cited by 374 · see citing works

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

Kagan, V. E., Serbinova, E. A., & Packer, L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91971-t · Cited by 363 · see citing works

Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study

Rustin, P., von Kleist-Retzow, J., Chantrel-Groussard, K., Sidi, D., Münnich, A., & Rötig, A. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01341-0 · Cited by 348 · see citing works

Coenzyme Q₁₀ levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410420221 · Cited by 326 · see citing works

Uncoupling proteins 2 and 3 are highly active H ⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

Echtay, K. S., Winkler, E., Frischmuth, K., & Klingenberg, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1416 · Cited by 313 · see citing works

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

Gu, M., Cooper, J. A. D., Taanman, J., & Schapira, A. H. V. (1998) · Annals of Neurology · doi:10.1002/ana.410440207 · Cited by 313 · see citing works

Parkinson's disease, pesticides, and glutathione transferase polymorphisms

Menegon, A., Philip G. Board, Blackburn, A. C., Mellick, G. D., & Couteur, D. G. L. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03453-9 · Cited by 312 · see citing works

Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease

Andreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0406 · Cited by 293 · see citing works

Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease

Hattori, N., Tanaka, M., Ozawa, T., & Mizuno, Y. (1991) · Annals of Neurology · doi:10.1002/ana.410300409 · Cited by 275 · see citing works

Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl- l - carnitine and/or R -α-lipoic acid

Liu, J., Killilea, D. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709098 · Cited by 266 · see citing works

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

Beal, M. F., Matthews, R. T., Tieleman, A., & Shults, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01192-x · Cited by 256 · see citing works

Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study

Caparros-Lefebvre, D., & Elbaz, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10166-6 · Cited by 256 · see citing works

Acetyl- l -carnitine fed to old rats partially restores mitochondrial function and ambulatory activity

Hagen, T. M., Ingersoll, R. T., Wehr, C. M., Lykkesfeldt, J., Vinarsky, V., Bartholomew, J. C., Song, M. H., & Ames, B. N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9562 · Cited by 252 · see citing works

Idebenone and reduced cardiac hypertrophy in Friedreich's ataxia

HAUSSE, A., Aggoun, Y., Bonnet, D., Sidi, D., Münnich, A., Rötig, A., & Rustin, P. (2002) · Heart · doi:10.1136/heart.87.4.346 · Cited by 251 · see citing works

An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

Beyer, R. E. (1992) · Biochemistry and Cell Biology · doi:10.1139/o92-061 · Cited by 250 · see citing works

MITOCHONDRIAL FUNCTION IN PARKINSON'S DISEASE

Bindoff, L. A., Birch‐Machin, M. A., Cartlidge, N. E. F., Parker, W. D., & Turnbull, D. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90291-2 · Cited by 245 · see citing works

Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders

Tarnopolsky, M. A., & Beal, M. F. (2001) · Annals of Neurology · doi:10.1002/ana.1028 · Cited by 244 · see citing works

The role of creatine kinase in inhibition of mitochondrial permeability transition

O’Gorman, E., Beutner, G., Dolder, M., Koretsky, A. P., Brdiczka, D. G., & Wallimann, T. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01045-4 · Cited by 243 · see citing works

Protective effect of the energy precursor creatine against toxicity of glutamate and β-amyloid in rat hippocampal neurons

Brewer, G. J., & Wallimann, T. W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741968.x · Cited by 230 · see citing works

Regulation of ubiquinone metabolism

Dallner, G., & Sindelar, P. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00307-5 · Cited by 199 · see citing works

Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation

Guan, M. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.6.573 · Cited by 193 · see citing works

Coenzyme Q₁₀ and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

Beal, M. F., Henshaw, D. R., Jenkins, B. G., Rosen, B. R., & Schulz, J. B. (1994) · Annals of Neurology · doi:10.1002/ana.410360613 · Cited by 189 · see citing works

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

Stachowiak, O., Dolder, M., Wallimann, T., & Richter, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16694 · Cited by 189 · see citing works

Ginkgo biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide

Oyama, Y., Chikahisa, L., Ueha, T., Kanemaru, K., & Noda, K. (1996) · Brain Research · doi:10.1016/0006-8993(95)01440-3 · Cited by 188 · see citing works

Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

Marangon, K., Devaraj, S., Tirosh, O., Packer, L., & Jialal, I. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00155-0 · Cited by 182 · see citing works

Mitochondria in Sporadic Amyotrophic Lateral Sclerosis

Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Trimmer, P. A., Miller, S. W., Maguire, D., Sheehan, J. P., Maguire, R. S., Pattee, G. L., Juel, V. C., et al. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6866 · Cited by 180 · see citing works

α-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats

Panigrahi, M., Sadguna, Y., Shivakumar, B. R., Kolluri, S. V. R., Roy, S., Packer, L., & Ravindranath, V. (1996) · Brain Research · doi:10.1016/0006-8993(96)00009-1 · Cited by 176 · see citing works

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2

Krauss, S., Zhang, C., & Lowell, B. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012410699 · Cited by 173 · see citing works

Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

Casteilla, L., Rigoulet, M., & Pénicaud, L. (2001) · IUBMB Life · doi:10.1080/15216540152845984 · Cited by 170 · see citing works

Electron Transport-Linked Ubiquinone-Dependent Recycling of α-Tocopherol Inhibits Autooxidation of Mitochondrial Membranes

Lass, A., & Sohal, R. S. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0606 · Cited by 162 · see citing works

A nuclear-mitochondrial DNA interaction affecting hearing impairment in mice

Johnson, K. R., Zheng, Q. Y., Bykhovskaya, Y., Spirina, O., & Fischel‐Ghodsian, N. (2001) · Nature Genetics · doi:10.1038/84831 · Cited by 157 · see citing works

The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance

Poderoso, J. J., Carreras, M. C., Schopfer, F. J., Lisdero, C. L., Galdo, N. A. R., Giulivi, C., Boveris, A. D., Boveris, A., & Cadenas, E. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00277-9 · Cited by 156 · see citing works

Ginkgo biloba extract (egb 761): inhibitory effect on nitric oxide production in the macrophage cell line raw 264.7

Kobuchi, H., Droy-Lefaix, M. T., Christen, Y., & Packer, L. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00873-8 · Cited by 154 · see citing works

Antioxidant action of ubiquinol homologues with different isoprenoid chain length in biomembranes

Kagan, V. E., Serbinova, E. A., Koynova, G. M., Kitanova, S., Tyurin, V. A., Stoytchev, T., Quinn, P. J., & Packer, L. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90114-x · Cited by 147 · see citing works

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

Simon, D. K., Pulst, S. M., Sutton, J. P., Browne, S. E., Beal, M. F., & Johns, D. R. (1999) · Neurology · doi:10.1212/wnl.53.8.1787 · Cited by 141 · see citing works

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

Brdiczka, D. G., Beutner, G., Rück, A., Dolder, M., & Wallimann, T. (1998) · BioFactors · doi:10.1002/biof.5520080311 · Cited by 138 · see citing works

Mitochondrial creatine kinase mediates contact formation between mitochondrial membranes.

Rojo, M., Hovius, R., DEMEL, R. A., Nicolay, K., & Wallimann, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54921-8 · Cited by 134 · see citing works

The Cloning and Expression of a Human Creatine Transporter

Sora, I., Richman, J., Santoro, G. P., Wei, H.-B., Wang, Y., Vanderah, T. W., Horváth, R., Nguyen, M., Waite, S. L., Roeske, W. R., et al. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2475 · Cited by 132 · see citing works

Kinetic study of free-radical-scavenging action of biological hydroquinones (reduced forms of ubiquinone, vitamin K and tocopherol quinone) in solution

Mukai, K., Morimoto, H., Kikuchi, S., & Nagaoka, S. (1993) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(93)90115-o · Cited by 126 · see citing works

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

Andreassen, O. A., Ferrante, R. J., Dedeoglu, A., & Beal, M. F. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00044 · Cited by 115 · see citing works

Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats

Ayoub, I. A., Lee, E. J., Ogilvy, C. S., Beal, M. F., & Maynard, K. I. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00881-7 · Cited by 107 · see citing works

Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine

Guthmiller, P., Pilsum, J. F. V., Boen, J. R., & McGuire, D. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32477-8 · Cited by 106 · see citing works

Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson’s disease

Simon, D. K., Mayeux, R. P., Marder, K. S., Kowall, N. W., Beal, M. F., & Johns, D. R. (2000) · Neurology · doi:10.1212/wnl.54.3.703 · Cited by 106 · see citing works

Dihydrolipoic Acid Maintains Ubiquinone in the Antioxidant Active Form by Two-Electron Reduction of Ubiquinone and One-Electron Reduction of Ubisemiquinone

Kozlov, A. V., Gille, L., Staniek, K., & Nohl, H. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1064 · Cited by 106 · see citing works

A common mitochondrial DNA variant associated with susceptibility to dilated cardiomyopathy in two different populations

Khogali, S., Mayosi, B. M., Beattie, J. M., McKenna, W. J., Watkins, H. C., & Poulton, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04422-6 · Cited by 104 · see citing works

Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity

Schulz, J. B., Ross Henshaw, D., Matthews, R. T., & Flint Beal, M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90033-0 · Cited by 103 · see citing works

Protective actions of l-carnitine and acetyl-l-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors

Virmani, A., Biselli, R., Spadoni, A., Rossi, S., Corsico, N., Calvani, M., Fattorossi, A., Simone, C. D., & Arrigoni‐Martelli, E. (1995) · Pharmacological Research · doi:10.1016/s1043-6618(05)80044-1 · Cited by 101 · see citing works

Cardiac energetics are abnormal in Friedreich ataxia patients in the absence of cardiac dysfunction and hypertrophy: An in vivo 31P magnetic resonance spectroscopy study

Lodi, R. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00357-1 · Cited by 101 · see citing works

Succinate-ubiquinone reductase linked recycling of α-tocopherol in reconstituted systems and mitochondria: Requirement for reduced ubiquinone

Maguire, J. J., Kagan, V. E., Ackrell, B. A. C., Serbinova, E. A., & Packer, L. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90049-3 · Cited by 95 · see citing works

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

Xu, C. J., Klunk, W. E., Kanfer, J. N., Xiong, Q. P., Miller, G., & Pettegrew, J. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.23.13435 · Cited by 95 · see citing works

Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia

Wolz, P., & Krieglstein, J. (1996) · Neuropharmacology · doi:10.1016/0028-3908(95)00172-7 · Cited by 95 · see citing works

Altered redox state of platelet coenzyme Q 10 in Parkinson's disease

Götz, M. E., Gerstner, A., Harth, R., Dirr, A., Janetzky, B., Kuhn, W., Riederer, P., & Gerlach, M. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050003 · Cited by 93 · see citing works

Decreases in mouse brain NAD+ and ATP induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): prevention by the poly(ADP-ribose) polymerase inhibitor, benzamide

Cosi, C., & Marien, M. R. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00829-4 · Cited by 87 · see citing works

Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury

Müller, U., & Krieglstein, J. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.77 · Cited by 84 · see citing works

Preincubation with Creatine Enhances Levels of Creatine Phosphate and Prevents Anoxic Damage in Rat Hippocampal Slices

Carter, A. J., MULLER, R. E., Pschorn, U., & Stransky, W. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062691.x · Cited by 83 · see citing works

Protection against peroxynitrite‐dependent tyrosine nitration and α1‐antiproteinase inactivation by oxidized and reduced lipoic acid

Whiteman, M., Tritschler, H., & Halliwell, B. B. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01489-6 · Cited by 81 · see citing works

Relations Between Tocopherol Depletion and Coenzyme Q During Lipid Peroxidation in rat Liver Mitochondria

Noack, H., Kube, U., & Augustin, W. (1994) · Free Radical Research · doi:10.3109/10715769409145637 · Cited by 81 · see citing works

Therapeutic Efficacy of EGb761 (Gingko biloba Extract) in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Ferrante, R. J., Klein, A., Dedeoglu, A., & Beal, M. F. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:1:89 · Cited by 78 · see citing works

Sequence Analysis of the Entire Mitochondrial Genome in Parkinson's Disease

Vives-Bauzá, C., Andreu, A. L., Manfredi, G., Beal, M. F., Janetzky, B., Gruenewald, T. H., & Lin, M. T. S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6388 · Cited by 73 · see citing works

Effect of acetyl-l-carnitine on recovery of brain phosphorus metabolites and lactic acid level during reperfusion after cerebral ischemia in the rat — study by 13P- and 1H-NMR spectroscopy

Aureli, T., Miccheli, A., Cocco, M. E. D., Ghirardi, O., Giuliani, A., Ramacci, M. T., & Conti, F. (1994) · Brain Research · doi:10.1016/0006-8993(94)90013-2 · Cited by 67 · see citing works

Anoxic ATP depletion in neonatal mice brainstem is prevented by creatine supplementation

Wilken, B., Ramirez, J., Probst, I., Richter, D. W., & Hanefeld, F. A. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.82.3.f224 · Cited by 54 · see citing works

Serum levels of coenzyme Q10 in patients with Parkinson's disease

Jiménez‐Jiménez, F. J., Molina, J. A., de Bustos, F., García‐Redondo, A., Gómez-Escalonilla, C., Martínez‐Salio, A., Berbel, Á., Camacho, A., Zurdo, M., Barcenilla, B., et al. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050015 · Cited by 50 · see citing works

Effect of lipoic acid on redox state of coenzyme Q in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate

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Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: Involvement of dopamine release and oxidative damage

Zhao, Y., Bu, Q., Zhou, Y. N., Lv, L., Yan, G., Chen, B., Wang, L., & Cen, X. (2010) · NeuroToxicology · doi:10.1016/j.neuro.2010.06.005 · Cited by 56 · see citing works

The Neuroprotective Role of Creatine

Klein, A., & Ferrante, R. J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6486-9_11 · Cited by 56 · see citing works

Acetyl-l-carnitine reduces impulsive behaviour in adolescent rats

Adriani, W., Rea, M., Baviera, M., Invernizzi, R. W., Carli, M., Ghirardi, O., Caprioli, A., & Giovanni Laviola, A. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1892-9 · Cited by 56 · see citing works

Mitochondrial Reactive Oxygen Species Inactivate Neuronal Nicotinic Acetylcholine Receptors and Induce Long-Term Depression of Fast Nicotinic Synaptic Transmission

Campanucci, V. A., Krishnaswamy, A., & Cooper, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5130-07.2008 · Cited by 54 · see citing works

Neuroprotective Therapy in Parkinson Disease

Chen, S., & Le, W. (2006) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000174353.28012.a7 · Cited by 53 · see citing works

Therapeutic attenuation of mitochondrial dysfunction and oxidative stress in neurotoxin models of Parkinson's disease

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Parkinson's disease: the first common neurological disease due to auto-intoxication?

Williams, A. C., Cartwright, L. S., & Ramsden, D. B. (2005) · QJM · doi:10.1093/qjmed/hci027 · Cited by 52 · see citing works

Real-Time Monitoring of Oxidative Stress in Live Mouse Skin

Wolf, A. M., Nishimaki, K., Kamimura, N., & Ohta, S. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.428 · Cited by 51 · see citing works

Protective Effects of Coenzyme Q10 Against Hydrogen Peroxide-Induced Oxidative Stress in PC12 Cell: The Role of Nrf2 and Antioxidant Enzymes

Li, L., Du, J., Lian, Y., Zhang, Y. L., Li, X., Liu, Y., Zou, L., & Wu, T. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0224-4 · Cited by 51 · see citing works

Rationale for the use of dopamine agonists as neuroprotective agents in Parkinson's disease

Schapira, A. H. V., & Olanow, C. W. (2003) · Annals of Neurology · doi:10.1002/ana.10514 · Cited by 50 · see citing works

Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms

Esposito, E., Toso, R. D., Pressi, G., Bramanti, P., Meli, R., & Cuzzocrea, S. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0466-0 · Cited by 49 · see citing works

Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation

Molinari, C., Morsanuto, V., Ghirlanda, S., Ruga, S., Notte, F., Gaetano, L., & Uberti, F. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2843121 · Cited by 49 · see citing works

Effects of Astaxanthin Supplementation on Oxidative Stress

Wu, D., Xu, H. Y., Chen, J., & Zhang, L. (2019) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000497 · Cited by 49 · see citing works

Natural compounds: evidence for a protective role in eye disease

Ritch, R. H. (2007) · Canadian Journal of Ophthalmology · doi:10.3129/can.j.ophthalmol.i07-044 · Cited by 47 · see citing works

Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease

Beal, M. F. (2009) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(09)70812-0 · Cited by 103 · see citing works

Mitochondria: Prospective Targets for Neuroprotection in Parkinson’s Disease

Yadav, A., Agarwal, S., Tiwari, S. K., & Chaturvedi, R. K. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140305224545 · Cited by 22 · see citing works

Mitochondrial therapy for Parkinson’s disease: Neuroprotective pharmaconutrition may be disease-modifying

KONES, R. J. (2010) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s12082 · Cited by 11 · see citing works

Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease

Beal, M. F. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07470.x · Cited by 523 · see citing works

Nonel approaches to correction of mitochondrial dysfunction and oxidative disorders in Parkinson’s disease

Gonchar, O. O., Im, M., Rozova, K. V., Bratus, L. V., & In, K. (2019) · Fìzìologìčnij žurnal · doi:10.15407/fz65.03.061 · Cited by 6 · see citing works