Role of MC4 receptors in the depressor and bradycardic effects of α-MSH in the nucleus tractus solitarii of the rat
Abstract
The receptor subtype(s) responsible for the cardiovascular actions of the melanocortins remains to be elucidated. This study investigated the cardiovascular effects of central injection of alpha-MSH and a potent cyclic MC3/4 receptor agonist, MTII, in the presence and absence of the newly developed MC4 receptor selective antagonist, HS014. Both alpha-MSH (250 pmol) and MTII (20-500 pmol) produced a rapid decrease in blood pressure and heart rate after injection into the nucleus tractus solitarii (NTS) of urethane-anaesthetised male Sprague-Dawley rats. These responses were attenuated in a dose-dependent manner by prior local NTS blockade with HS014 (20 or 100 pmol), providing evidence for the role of the MC4 receptor in the cardiovascular changes following NTS injection of melanocortins in the rat.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The blood pressure-lowering response to microinjections of α-MSH into the dorsal motor nucleus of the vagus complex or the nucleus tractus solitarius was attenuated by MC4R blockade.
“The acute effects of CNS injections of α-MSH on BP depend on the brain area where it activates its receptors since microinjections of α-MSH into the dorsal motor nucleus of the vagus (DMV) complex or the NTS lowered BP [25, 26] and this response was attenuated by MC4R blockade.”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [25]
Microinjections of α-MSH into the dorsal motor nucleus of the vagus complex or the nucleus tractus solitarius lowered blood pressure.
“The acute effects of CNS injections of α-MSH on BP depend on the brain area where it activates its receptors since microinjections of α-MSH into the dorsal motor nucleus of the vagus (DMV) complex or the NTS lowered BP [25, 26] and this response was attenuated by MC4R blockade.”
From Role of the brain melanocortins in blood pressure regulation (2017) · cites this paper as [25]
Cites
Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157 · see citing works
Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
Haynes, W. G., Morgan, D. A., Djalali, A., Sivitz, W. I., & Mark, A. L. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.542 · Cited by 358 · see citing works
Grill, H. J., Ginsberg, A. B., Seeley, R. J., & Kaplan, J. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10128.1998 · Cited by 277 · see citing works
Brainstem and bulbospinal neurotransmitter systems in the control of blood pressure
Chalmers, J. P., & Pilowsky, P. M. (1991) · Journal of Hypertension · doi:10.1097/00004872-199108000-00001 · Cited by 261 · see citing works
Molecular Cloning and Characterisation of the Rat Fifth Melanocortin Receptor
Griffon, N., Mignon, V., Facchinetti, P., Díaz, J., Schwartz, J., & Sokoloff, P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1550 · Cited by 195 · see citing works
Li, S.-J., Varga, K., Archer, P., Hruby, V. J., Sharma, S. D., Kesterson, R. A., Cone, R. D., & Kunos, G. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05182.1996 · Cited by 152 · see citing works
Discovery of novel melanocortin4 receptor selective MSH analogues
Schiöth, H. B., Mutulis, F., Muceniece, R., Prūsis, P., & Wikberg, J. E. S. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701804 · Cited by 137 · see citing works
Self-citationBrain Melanocortin Receptors: From Cloning to Function
Adan, R. A. H., & Gispen, W. H. (1997) · Peptides · doi:10.1016/s0196-9781(97)00078-8 · Cited by 137 · see citing works
Melanocortins and cardiovascular regulation
Versteeg, D. H. G., Van Bergen, P., Adan, R. A. H., & De Wildt, D. J. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00615-3 · Cited by 98 · see citing works
Bertolini, A., Guarini, S., Rompianesi, E., & Ferrari, W. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90179-2 · Cited by 96 · see citing works
Schiöth, H. B., Muceniece, R., Mutulis, F., Prūsis, P., Lindeberg, G., Sharma, S. D., Hruby, V. J., & Wikberg, J. E. S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00079-x · Cited by 87 · see citing works
Self-citationHansen, M. J., Ball, M. J., & Morris, M. J. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03246-7 · Cited by 72 · see citing works
Self-citationLindblom, J., Schiöth, H. B., Larsson, A. C., et al. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00918-4 · Cited by 70 · see citing works
Self-citationMurphy, B. A., Nunes, C. N., Ronan, J. J., Hanaway, M., Fairhurst, A., & Mellin, T. N. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.273 · Cited by 68 · see citing works
Dunbar, J. C., & Lu, H. (2000) · Peptides · doi:10.1016/s0196-9781(99)00192-8 · Cited by 67 · see citing works
Kawai, Y., Inagaki, S., Shiosaka, S., Shibasaki, T., LING, N. C., Tohyama, M., & Shiotani, Y. (1984) · Brain Research · doi:10.1016/0006-8993(84)90539-0 · Cited by 55 · see citing works
Guarini, S., Bazzani, C., Cainazzo, M. M., Mioni, C., Ferrazza, G., Vergoni, A. V., Schiöth, H. B., Wikberg, J. E. S., & Bertolini, A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35205-x · Cited by 44 · see citing works
Self-citationSurvival rate after early treatment for acute type-A aortic dissection with ACTH-(1–24)
Noera, G., Lamarra, M., Guarini, S., & Bertolini, A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05631-8 · Cited by 43 · see citing works
Yamazoe, M., Shiosaka, S., Yagura, A., et al. (1984) · Peptides · doi:10.1016/0196-9781(84)90013-5 · Cited by 42 · see citing works
Cardiovascular effects of γ-MSH/ACTH-like peptides: structure-activity relationship
Van Bergen, P., Janssen, P. M. L., Hoogerhout, P., De Wildt, D. J., & Versteeg, D. H. G. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00657-5 · Cited by 40 · see citing works
Wildt, D. J. D., Ven, J. C. V. D., Bergen, P. V., Lang, H. D., & Versteeg, D. H. G. (1994) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00178205 · Cited by 31 · see citing works
Fodor, M., Sluiter, A. A., Frankhuijzen-Sierevogel, A. C., Wiegant, V. M., Hoogerhout, P., Wildt, D. J. D., & Versteeg, D. H. G. (1996) · Brain Research · doi:10.1016/0006-8993(96)00464-7 · Cited by 25 · see citing works
Callahan, M. F., Cunningham, J. T., Kirby, R. F., Johnson, A. K., & Gruber, K. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90925-0 · Cited by 22 · see citing works
α-MSH exhibits opioid antagonist-like effects in the brainstem of rats
Carter, D., & Lightman, S. L. (1987) · Peptides · doi:10.1016/0196-9781(87)90150-1 · Cited by 11 · see citing works
Sun, X. Y., Edvinsson, L. I., & Hedner, T. (1991) · Journal of Hypertension · doi:10.1097/00004872-199112006-00156 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kievit, P., Halem, H., Marks, D. L., Dong, J. Z., Glavas, M. M., Sinnayah, P., Pranger, L., Cowley, M. A., Grove, K. L., & Culler, M. D. (2013) · Diabetes · doi:10.2337/db12-0598 · Cited by 231 · see citing works
Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones
Ni, X.-P., Butler, A. A., Cone, R. D., & Humphreys, M. H. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000249702.49854.fa · Cited by 88 · see citing works
da Silva, A. A., do Carmo, J. M., Kanyicska, B., Dubinion, J., Brandon, E., & Hall, J. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100636 · Cited by 79 · see citing works
Role of Adrenergic Activity in Pressor Responses to Chronic Melanocortin Receptor Activation
Kuo, J. J., da Silva, A. A., Tallam, L. S., & Hall, J. E. (2004) · Hypertension · doi:10.1161/01.hyp.0000111836.54204.93 · Cited by 68 · see citing works
γ-MSH, sodium metabolism, and salt-sensitive hypertension
Humphreys, M. H. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00365.2003 · Cited by 51 · see citing works
The Brain Melanocortin System, Sympathetic Control, and Obesity Hypertension
da Silva, A. A., do Carmo, J. M., Wang, Z., & Hall, J. E. (2014) · Physiology · doi:10.1152/physiol.00061.2013 · Cited by 47 · see citing works
do Carmo, J. M., da Silva, A. A., Rushing, J. S., Pace, B., & Hall, J. E. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00518.2012 · Cited by 38 · see citing works
Role of the brain melanocortins in blood pressure regulation
do Carmo, J. M., da Silva, A. A., Wang, Z., Fang, T., Aberdein, N., Perez de Lara, C. E., & Hall, J. E. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.003 · Cited by 38 · see citing works
Tai, M.-H., Weng, W.-T., Lo, W.-C., Chan, J. Y. H., Lin, C.-J., Lam, H.-C., & Tseng, C.-J. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.118299 · Cited by 24 · see citing works
Chitravanshi, V. C., Bhatt, S., & Sapru, H. N. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90978.2008 · Cited by 16 · see citing works
- Authors
- Pavia, J. M., Schiöth, H. B., & Morris, M. J.
- Affiliations
- Uppsala University (SE)
- The University of Melbourne (AU)
- Venue
- Neuroreport
- Published
- 2003-04
- Volume
- 14
- Issue
- 5
- Pages
- 703-707
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2009640186
- Cited by
- 25
- References
- 25
- Citations by year
- 2017: 1 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- melanocortin-4 receptor, alpha-melanocyte-stimulating hormone, melanotan II, nucleus tractus solitarius, blood pressure, heart rate, melanocortin peptides, cardiovascular effects, receptor antagonism, central injection
- MeSH terms
- alpha-MSH, Animals, Blood Pressure, Bradycardia, Cardiovascular System, Cardiovascular Physiological Phenomena, Dose-Response Relationship, Drug, Heart Rate, Male, Microinjections, Peptides, Cyclic, Time Factors, Rats, Sprague-Dawley, Solitary Nucleus, Receptors, Corticotropin, Receptor, Melanocortin, Type 4, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
