Increased presynaptic dopamine function in Asperger syndrome
Abstract
The etiology of Asperger syndrome is essentially unknown, but abnormality of the dopamine system has been shown in clinically overlapping disorders. The present study was designed to investigate the presynaptic dopamine function in Asperger syndrome. Eight healthy, drug-free males with Asperger syndrome and five healthy male controls were examined with positron emission tomography using 6-[18F]fluoro-L-DOPA ([18F]FDOPA) as a tracer. In the Asperger syndrome group, the [18F]FDOPA influx (Ki) values were increased in the striatum, i.e. in the putamen and caudate nucleus and in the frontal cortex. The results indicate that the dopamine system is affected in subjects with Asperger syndrome. Partially similar results have also been obtained in schizophrenia, suggesting an overlap not only of the clinical features but also of pathogenesis.
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Nieminen-von Wendt et al. found no evidence of reduced ventromedial prefrontal cortex DA metabolism in children with ASDs.
“whereas Nieminen-von Wendt and colleagues [588] found no such evidence.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [588]
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- Authors
- Nieminen-von Wendt, T. S., Metsähonkala, L., Kulomäki, T. A., Aalto, S., Autti, T. H., Vanhala, R., Eskola, O., Bergman, J., Hietala, J. A., & von Wendt, L. O.
- Affiliations
- Turku PET Centre (FI)
- Venue
- NeuroReport
- Published
- 2004-04
- Volume
- 15
- Issue
- 5
- Pages
- 757-760
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1964414015
- Cited by
- 40
- References
- 20
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Asperger syndrome, dopaminergic system, striatum, putamen, caudate nucleus, frontal cortex, dopamine transporter, schizophrenia, neuroimaging
- MeSH terms
- Adult, Basal Ganglia, Dihydroxyphenylalanine, Dopamine, Fluorine Radioisotopes, Frontal Bone, Humans, Functional Laterality, Male, Tomography, Emission-Computed, Presynaptic Terminals, Asperger Syndrome
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