Low medial prefrontal dopaminergic activity in autistic children
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Ernst et al. found reduced ventromedial prefrontal cortex DA metabolism in children with ASDs.
“Ernst and colleagues [587] found reduced ventromedial prefrontal cortex DA metabolism in children with ASDs”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [587]
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Tan, Z., Wei, H., Song, X., Mai, W., Yan, J., Ye, W., Ling, X., Hou, L., Zhang, S., Yan, S., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.806876 · Cited by 26 · see citing works
Greene, R. K., Walsh, E. C., Mosner, M. G., & Dichter, G. S. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.12.008 · Cited by 28 · see citing works
de Theije, C. G. M., van den Elsen, L. W. J., Willemsen, L. E. M., Milosevic, V., Korte-Bouws, G. A. H., da Silva, S. L., Broersen, L. M., Korte, S. M., Olivier, B., Garssen, J., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.001 · Cited by 26 · see citing works
- Authors
- Ernst, M., Zametkin, A., Matochik, J., Pascualvaca, D., & Cohen, R.
- Affiliations
- National Institutes of Health (US)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 350
- Issue
- 9078
- Pages
- 638
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2083953112
- Cited by
- 246
- References
- 6
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 11 · 2021: 17 · 2020: 18 · 2019: 13 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 14
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, medial prefrontal cortex, dopaminergic dysfunction, dopamine, theory of mind, Asperger syndrome, children, homovanillic acid, dopamine antagonists, social dysfunction
- MeSH terms
- Autistic Disorder, Child, Dopamine, Female, Humans, Male, Tomography, Emission-Computed, Prefrontal Cortex
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