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Cited by 66Sleep and Wakefulness ResearchNeuroscience and Neuropharmacology ResearchSleep and related disorders

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Sleep EEG changes after zolpidem in mice

Kopp, Caroline, Rudolph, Uwe, Tobler, Irene·2004·NeuroReport
DOI 10.1097/00001756-200410050-00031
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Abstract

Zolpidem is a widely used hypnotic that binds preferentially to alpha1GABAA receptors. We determined the role of these receptors in the effects of zolpidem on sleep in mutant mice carrying zolpidem-insensitive alpha1GABAA receptors and wild-type controls. Sleep was promoted by zolpidem in both genotypes. In wild-type mice non-REM sleep EEG power was markedly reduced in a broad frequency band >5 or 9 Hz after 5 and 10 mg/kg zolpidem, respectively. In mutants a power reduction appeared at the highest dose only, and was restricted to some low frequencies and the 9-10 Hz bin. We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by alpha1GABAA receptors.

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Crossref · 10.1097/00001756-200410050-00031

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  • Other studies reported divergent observations with regard to the effects of zolpidem on EEG sigma power, micro-arousals and consolidation of memory.

    “Other studies reported divergent observations with regard to the effects of zolpidem on EEG sigma power, micro-arousals and consolidation of memory67,68,95,96.”

    From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [67]

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Metadata

Authors
Kopp, C., Rudolph, U., & Tobler, I.
Affiliations
University of Zurich (CH)
ORCID
Rudolph, Uwe
Venue
NeuroReport
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2004-10
Volume
15
Issue
14
Pages
2299-2302
ISSN
0959-4965 (ISSN-L)
DOI
10.1097/00001756-200410050-00031
OpenAlex
W1997542405
Cited by
66
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 4 · 2014: 2 · 2013: 5 · 2012: 3
FWCI
1.33
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
zolpidem, sleep EEG, NREM sleep, hypnotics, EEG spectral power
MeSH terms
Zolpidem, Animals, Electroencephalography, Male, Mice, Mutant Strains, Pyridines, Sleep, Mice

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