The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
Abstract
In this study we revealed the participation of P2X(7) receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [(3)H]glutamate and [(3)H]GABA was decreased in the hippocampus of P2X(7) receptor-deficient mice. ATP (10 mM) elicited [(3)H]glutamate and [(3)H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium (30 microM) and the P2X(7)-selective antagonist Brilliant Blue G (1 microM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R.
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“In accordance with these results, glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of the P2X7R KO mice [99].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [99]
Citations
Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
The Cytolytic P 2Z Receptor for Extracellular ATP Identified as a P 2X Receptor (P2X 7 )
Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., & Buell, G. (1996) · Science · doi:10.1126/science.272.5262.735 · Cited by 1,739
Altered Cytokine Production in Mice Lacking P2X7Receptors
Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924
Rapid Secretion of Interleukin-1β by Microvesicle Shedding
Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862
Tissue distribution of the P2X7 receptor
Collo, G., Neidhart, S., Kawashima, E. H., Kosco‐Vilbois, M. H., North, R. A., & Buell, G. N. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00140-8 · Cited by 493
P2X 7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes
Duan, S., Anderson, C. M., Keung, E. C., Chen, Y., Chen, Y., & Swanson, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01320.2003 · Cited by 489
Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., & Posmantur, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209478200 · Cited by 488
Brilliant Blue G Selectively Blocks ATP-Gated Rat P2X7Receptors
Jiang, L., Mackenzie, A. B., North, R. A., & Surprenant, A. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.82 · Cited by 401
Production and Release of Neuroprotective Tumor Necrosis Factor by P2X7Receptor-Activated Microglia
Suzuki, T., Hide, I., Ido, K., Kohsaka, S., Inoue, K., & Nakata, Y. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3792-03.2004 · Cited by 394
The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death
Virgilio, F. D. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80045-x · Cited by 374
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Items 101–107 of 107
Purinergic Signaling in Depression
Ribeiro, D. E., Kaster, M. P., Ulrich, H., Lisboa, S. F. D. S., & Joca, S. R. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_7
Purinergic Signaling in Brain Physiology
Glaser, T., & Ulrich, H. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_3
BindingDB (2013) · UC San Diego · doi:10.7270/q2959jr1
Metadata
- Authors
- Papp, L., Vizi, E. S., & Sperlágh, B.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Venue
- Neuroreport
- Published
- 2004-10
- Volume
- 15
- Issue
- 15
- Pages
- 2387-2391
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2000362394
- Cited by
- 102
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- P2X7 receptor, GABA release, glutamate release, hippocampus, Brilliant Blue G, P2 receptor antagonists, electrical stimulation
- MeSH terms
- Adenosine Triphosphate, Analysis of Variance, Animals, Benzenesulfonates, Electric Stimulation, gamma-Aminobutyric Acid, Hippocampus, Platelet Aggregation Inhibitors, Pyridoxal Phosphate, RNA, Messenger, Tritium, Receptors, Purinergic P2, Mice, Knockout, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, Purinergic P2X7, In Vitro Techniques
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