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Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

Papp, Lilla, Vizi, E. Sylvester, Sperlágh, Beáta·2004·Neuroreport

DOI 10.1097/00001756-200410250-00017

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Abstract

In this study we revealed the participation of P2X(7) receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [(3)H]glutamate and [(3)H]GABA was decreased in the hippocampus of P2X(7) receptor-deficient mice. ATP (10 mM) elicited [(3)H]glutamate and [(3)H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium (30 microM) and the P2X(7)-selective antagonist Brilliant Blue G (1 microM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R.

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Authors: Papp, L., Vizi, E. S., & Sperlágh, B.
Affiliations: HUN-REN Institute of Experimental Medicine (HU)
ORCID: Vizi, E. Sylvester
Sperlágh, Beáta
Venue: Neuroreport
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-10
Volume: 15
Issue: 15
Pages: 2387-2391
ISSN: 0959-4965 (ISSN-L)
DOI: 10.1097/00001756-200410250-00017
OpenAlex: W2000362394
Cited by: 102
References: 26
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
FWCI: 3.48
Type: journal article
Language: en
Open access: closed
Locations: Neuroreport (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: P2X7 receptor, GABA release, glutamate release, hippocampus, Brilliant Blue G, P2 receptor antagonists, electrical stimulation
MeSH terms: Adenosine Triphosphate, Analysis of Variance, Animals, Benzenesulfonates, Electric Stimulation, gamma-Aminobutyric Acid, Hippocampus, Platelet Aggregation Inhibitors, Pyridoxal Phosphate, RNA, Messenger, Tritium, Receptors, Purinergic P2, Mice, Knockout, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, Purinergic P2X7, In Vitro Techniques

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Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

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