The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice
Abstract
In this study we revealed the participation of P2X(7) receptors in the modulation of electrical stimulation and ATP-evoked GABA and glutamate release from mouse hippocampal slices. Whereas the uptake of radioactivity was not changed, the electrical stimulation-induced release of both [(3)H]glutamate and [(3)H]GABA was decreased in the hippocampus of P2X(7) receptor-deficient mice. ATP (10 mM) elicited [(3)H]glutamate and [(3)H]GABA efflux in wild-type mice, which was inhibited by the non-selective P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium (30 microM) and the P2X(7)-selective antagonist Brilliant Blue G (1 microM). The ATP-evoked release of both GABA and glutamate was virtually absent in the knockout mice. These results indicate that ATP facilitates GABA and glutamate release in the hippocampus by a mechanism involving P2X(7)R.
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“In accordance with these results, glutamate and GABA release induced by both electrical stimulation or P2X7R activation were absent in hippocampal slices of the P2X7R KO mice [99].”
From P2X7 Receptor Signaling in Stress and Depression (2019) · cites this paper as [99]
Citations
Cites
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Metadata
- Authors
- Papp, L., Vizi, E. S., & Sperlágh, B.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Venue
- Neuroreport
- Published
- 2004-10
- Volume
- 15
- Issue
- 15
- Pages
- 2387-2391
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2000362394
- Cited by
- 102
- References
- 26
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 5 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 8
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- P2X7 receptor, GABA release, glutamate release, hippocampus, Brilliant Blue G, P2 receptor antagonists, electrical stimulation
- MeSH terms
- Adenosine Triphosphate, Analysis of Variance, Animals, Benzenesulfonates, Electric Stimulation, gamma-Aminobutyric Acid, Hippocampus, Platelet Aggregation Inhibitors, Pyridoxal Phosphate, RNA, Messenger, Tritium, Receptors, Purinergic P2, Mice, Knockout, Glutamic Acid, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, Purinergic P2X7, In Vitro Techniques
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