Form, function, and use of retroviral Gag proteins
Abstract
From the Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center — Shreveport, Shreveport, Louisiana, USA.
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Peptides and spacer peptides regulate the timing of Gag polyprotein processing, establish correct virion morphology/core condensate structures, and ensure proper virion budding from the host cell membrane.
“They achieve this by regulating the timing of Gag polyprotein processing and establishing correct virion morphology/core condensate structures within the virion, as well as ensuring proper virion budding from the host cell membrane”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Wills and Craven 1991
Peptides and spacer peptides have important roles in virion assembly to ensure generation of infectious virus particles.
“These peptides and spacer peptides have important roles in virion assembly to ensure the generation of “infectious” virus particles.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Wills and Craven 1991
The general organization of the Gag domains (MA, CA, and NC) is highly conserved among different retroviruses.
“The general organization of these Gag domains (MA, CA, and NC) is highly conserved among different retroviruses”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Wills and Craven 1991
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Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication
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“…the fundamental building block for retroviral particle assembly, often referred to as an “assembly machine,” where each assembling virus particle may contain as many as 2000–5000 Gag molecules (Wills et al. 1991 , Vogt and Simon 1999 , Briggs et al. 2004 , Carlson et al. 2008 , Chen et al. 2009 ).”
Influential
- Authors
- Wills, J. W., & Craven, R. C.
- Affiliations
- Louisiana State University (US)
- ORCID
- Wills, John W.
- Venue
- AIDS
- Published
- 1991-06
- Volume
- 5
- Issue
- 6
- Pages
- 639-654
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W1970630169
- Cited by
- 515
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 12 · 2012: 11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA-47482)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- retroviral assembly, HIV-1, retroviral replication
- MeSH terms
- Morphogenesis, Retroviridae, Virus Replication, Gene Products, gag
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