Cited by 15Virus-based gene therapy researchAdvanced Drug Delivery SystemsRNA Interference and Gene Delivery

Matrix Mediated Viral Gene Delivery: A Review

Steinhauff, Douglas, Ghandehari, Hamidreza·2019·Bioconjugate Chemistry

Abstract

Polymeric matrices inherently protect viral vectors from pre-existing immune conditions, limit dissemination to off-target sites, and can sustain vector release. Advancing methodologies in development of particulate based vehicles have led to improved encapsulation of viral vectors. Polymeric delivery systems have contributed to increasing cellular transduction, responsive release mechanisms, cellular infiltration, and cellular signaling. Synthetic polymers are easily customizable, and are capable of balancing matrix retention with cellular infiltration. Natural polymers contain inherent biorecognizable motifs adding therapeutic efficacy to the incorporated viral vector. Recombinant polymers use highly conserved motifs to carefully engineer matrices, allowing for precise design including elements of vector retention and responsive release mechanisms. Composite polymer systems provide opportunities to create matrices with unique properties. Carefully designed matrices can control spatiotemporal release patterns that synergize with approaches in regenerative medicine and antitumor therapies.

Integrity signals

Registry

Crossref · 10.1021/acs.bioconjchem.8b00853

Cites

194 of 194 references verified0 citation errors · 0 not checkable

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  • bioPROTACs would most likely be delivered as mRNA or DNA constructs via a viral vector gene delivery system or in a nanoparticle.

    “Indeed, bioPROTACs would most likely be delivered as mRNA or DNA constructs via a viral vector gene delivery system204–206 or in a nanoparticle207–209.”

    From PROTAC targeted protein degraders: the past is prologue (2022) · cites this paper as [208]

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Authors
Steinhauff, D., & Ghandehari, H.
Affiliations
  • University of Utah (US)
  • Utah Center for Nanomedicine, Nano Institute of Utah, 36 South Wasatch Drive, Salt Lake City, Utah 84112, United States
Corresponding author
Ghandehari, Hamidreza
Venue
Bioconjugate Chemistry
Published
2019-02-01
Volume
30
Issue
2
Pages
384-399
ISSN
  • 1043-1802 (ISSN-L)
  • 1520-4812
OpenAlex
W2915044621
Cited by
15
References
194
Citations by year
2026: 1 · 2025: 4 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 1
FWCI
0.23
Type
journal article
Language
en
Open access
closed
Locations
  • Bioconjugate Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (R01 CA107621, RO1CA227225)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
viral gene delivery, polymer matrix, viral vectors, polymeric nanoparticles, immune evasion, natural polymers, synthetic polymers, regenerative medicine, cancer therapy
MeSH terms
Animals, Gels, Genetic Vectors, Humans, Polymers, Viruses, Gene Transfer Techniques

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