Cited by 457HIV Research and TreatmentTelomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

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Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

Effros, Rita B., Allsopp, Richard, Chiu, Choy-pik, Hausner, Mary Ann, Hirji, Karim, Wang, Lili, Harley, Calvin B., Villeponteau, Bryant, West, Michael D., Giorgi, Janis V.·1996·AIDS

DOI 10.1097/00002030-199607000-00001

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Abstract

OBJECTIVE: To test the hypothesis that the expanded population of non-proliferative CD28-CD8+ T cells in HIV disease have shortened telomeres, thereby providing evidence that increased rounds of CD8+ cell division occur during HIV disease, possibly leading to replicative senescence and exhaustion of CD8+ T-cell responses. DESIGN: CD8+ cells play a central role in control of HIV infection. In late HIV disease, an expanded population of CD28-CD8+ cells with reduced proliferative potential has been documented. A similar population of CD28-CD8+ cells has been identified in ageing humans, where telomere length measurements have suggested that these cells have reached the irreversible state of replicative senescence. METHODS: CD8+ cells from HIV-infected and control subjects were sorted by flow cytometry into CD28+ and CD28- fractions. Telomere lengths were determined as mean terminal restriction fragment (TRF) lengths by Southern hybridization. RESULTS: The TRF lengths of sorted CD28-CD8+ cells in HIV-infected subjects ranged between 5 and 7 kilobases (kb) and were significantly shorter than TRF lengths of CD28-CD8+ cells in uninfected subjects (P = 0.003). The TRF length in CD28-CD8+ cells from HIV-infected subjects was the same as that observed for centenarian peripheral blood mononuclear cells and is compatible with a state of replicative senescence. CONCLUSIONS: The shortened telomeres in the CD28-CD8+ cells in HIV-infected subjects and the poor proliferative potential of these cells identifies CD8+ cell replicative senescence as a newly described feature of HIV disease. Our results provide a mechanism for the loss of CD8+ cell control of viral replication that accompanies advanced HIV disease. Replicative senescence may contribute to exhaustion of the T-cell response as a result of chronic HIV disease. Whether this phenomenon occurs in other chronic viral infections is unknown.

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Heaps, A. G. (2012) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000132 · Cited by 3
Lymphocyte subpopulations from patients with primary antibody deficiency do not show increased telomere erosion
Tucker, V. C., Rye, A., Harrison, J., King, L., Duddridge, M., & Browning, M. J. (2004) · Immunobiology · doi:10.1078/0171-2985-00292 · Cited by 3
Cytotoxic T lymphocytes in Human Immunodeficiency Virus type-1 infection Important or impotent?
Gamberg, J., & Grant, M. D. (2000) · Clinical and Applied Immunology Reviews · doi:10.1016/s1529-1049(00)00004-0 · Cited by 3
Multiparameter Flow Cytometry
Serke, S. (1998) · Springer eBooks · doi:10.1007/978-3-642-58803-7_2 · Cited by 3
HIV Infection as a Model of Accelerated Immunosenescence
Appay, V., Sauce, D., & Kelleher, A. D. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_50 · Cited by 4
Immune Reconstitution and Viral Stimulation Are Required to Restore HIV-Specific CD8 T Cell Responses Following Advanced Infection
Gamberg, J., Barrett, L., Bowmer, I., Howley, C., & Grant, M. D. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000019776.38147.e6 · Cited by 3
Effects of Subcutaneous IL‐2 Therapy on Telomere Lengths in PBMC in HIV‐Infected Patients
Aladdin, H., Larsen, C. S., Schjerling, P., Møller, B. K., Buhl, M. R., Gerstoft, J., Pedersen, B. K., & Ullum, H. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00876.x · Cited by 3
The senescence-inhibitory p53 isoform Δ133p53α: enhancing cancer immunotherapy and exploring novel therapeutic approaches for senescence-associated diseases
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LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset
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Changes in Cellular Senescence Biomarkers Across Individuals at Different Stages of HIV Infection Before and After a Year of Antiretroviral Therapy
Ayala-Suárez, R., Rodríguez-Agustín, A., Maleno, M. J., Rovira, C., de Lazzari, E., Chivite, I., Mallolas, J., Ambrosioni, J., Sánchez‐Palomino, S., Martínez, E., et al. (2026) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiag133 · Cited by 2
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Appay, V., & Sauce, D. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_50 · Cited by 2
Training intensity distribution, physiological adaptation and immune function in endurance athletes
Neal, C. M. (2011) · Stirling Online Research Repository (University of Stirling) · Cited by 2
T-Cell Dynamics and Renewal in HIV-1 Infection
Clark, D. R., & Wolthers, K. C. (2000) · Springer eBooks · doi:10.1007/978-94-017-0685-8_4 · Cited by 2
CD28 downregulation and expression of NK-associated receptors on T cells in aging and situations of chronic activation of the immune system
Casado, J. G., DelaRosa, O., Peralbo, E., Tarazona, R., & Solana, R. (2002) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(02)13007-0 · Cited by 2
Regulation of T Cell Senescence in Health and Diseases
Mun, S., Choi, S., Kim, J., Kim, J., & Chung, Y. (2026) · Immune Network · doi:10.4110/in.2026.26.e27 · Cited by 1
Family Adversity and Autonomic Reactivity Association With Immune Changes in HIV-Affected School Children
Thomas, M., Wara, D. W., Saxton, K. B., Truskier, M., Chesney, M. A., & Boyce, W. T. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31829807fb · Cited by 1
Im Alter rückt die HIV-Infektion in den Hintergrund
Mück, B., Trapana, G., & Jäger, H. (2012) · MMW - Fortschritte der Medizin · doi:10.1007/s15006-012-0622-1 · Cited by 1
Analysis of the prevalence and severity of clinical manifestations of papillomavirus infection in HIV-infected women of childbearing age
Radzikhovskaya, M. V., Anisimova, O. S., Magadeev, H. D., Москвичева, М. Г., Telesheva, L. F., & Magadeev, R. D. (2021) · HIV Infection and Immunosuppressive Disorders · doi:10.22328/2077-9828-2021-13-1-37-44 · Cited by 1
A Novel FACS-Based Workflow for Simultaneous Assessment of RedOx Status, Cellular Phenotype, and Mitochondrial Genome Stability
McTernan, P. M., Katz, P. S., Porretta, C. P., Welsh, D. A., & Siggins, R. W. (2021) · BioChem · doi:10.3390/biochem1010001 · Cited by 1
Exercise, epigenetics, and aging
Chilton, W., Maier, M. C., Akinnibosun, O. A., O’Brien, B. J., & Charchar, F. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820682-9.00002-5 · Cited by 1
The Immune System
Mitchell, W., & Aspinall, R. (2008) · CRC Press eBooks · doi:10.3109/9781420065985-2 · Cited by 1
Cytotoxic T Lymphocytes in HIV-1 Infection
Klein, M. R., van der Burg, S. H., & Autran, B. (2000) · Springer eBooks · doi:10.1007/978-94-017-0685-8_6 · Cited by 1
Generation and Gene Expression of CD28-CD8 T-cells in Human
Weng, N. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_17 · Cited by 1
Telomeres and Replicative Senescence
Allsopp, R., Wang, S., Kim, N., & Harley, C. B. (1998) · CRC Press eBooks · doi:10.1201/b14256-24 · Cited by 1
Self-citation
Constraints on the CD8 T cell response in chronic HBV infection
Das, A. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Authors: Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V.
Affiliations: University of California, Los Angeles (US)
ORCID: Effros, Rita B.
Allsopp, Richard
Villeponteau, Bryant
West, Michael D.
Venue: AIDS
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-07
Volume: 10
Issue: 8
Pages: F17-22
ISSN: 0269-9370 (ISSN-L)
DOI: 10.1097/00002030-199607000-00001
OpenAlex: W1988707875
Cited by: 457
References: 0
Citations by year: 2026: 4 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 15 · 2020: 4 · 2019: 10 · 2018: 13 · 2017: 13 · 2016: 10 · 2015: 15 · 2014: 12 · 2013: 15 · 2012: 19
FWCI: 9.74
Type: journal article
Language: en
Open access: closed
Locations: AIDS (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai032883-05)
National Institute of Allergy and Infectious Diseases (U01AI035040, AI-32883, AI-28 697, P30AI028697, AI35040)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: telomere shortening, replicative senescence, HIV infection, CD8+ T cell exhaustion, T cell proliferation, chronic viral infection, immunosenescence
MeSH terms: Cell Division, DNA, Humans, Molecular Weight, HIV Infections, T-Lymphocyte Subsets, Telomere, Cellular Senescence, CD28 Antigens, CD8-Positive T-Lymphocytes

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Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

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