Effros, Rita B.

Chronic inflammation in the etiology of disease across the life span

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

Cited by 4,915

. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions.

Effros, R. B., Fletcher, C. V., Gebo, K., Halter, J. B., Hazzard, W. R., Horne, F. M., Huebner, R. E., Janoff, E. N., Justice, A. C., Kuritzkes, D., et al. (2008) · Clinical Infectious Diseases

HIV-related health complications and treatmentsHIV Research and Treatment

Cited by 539

HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group

High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes

HIV-related health complications and treatmentsHIV Research and Treatment

Cited by 522

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

Effros, R. B., Allsopp, R., Chiu, C.-P., Hausner, M. A., Hirji, K., Wang, L., Harley, C. B., Villeponteau, B., West, M. D., & Giorgi, J. V. (1996) · AIDS

HIV Research and TreatmentTelomeres, Telomerase, and Senescence

Cited by 457

Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence

Effros, R. B., Boucher, N., Porter, V., Zhu, X., Spaulding, C., Walford, R. L., Kronenberg, M., Cohen, D., & Schächter, F. (1994) · Experimental Gerontology

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 377

Reduced telomerase activity in human T lymphocytes exposed to cortisol

Choi, J., Fauce, S. R., & Effros, R. B. (2008) · Brain, Behavior, and Immunity

Telomeres, Telomerase, and SenescenceStress Responses and Cortisol

Cited by 352

Immunosenescence: what does it mean to health outcomes in older adults?

McElhaney, J. E., & Effros, R. B. (2009) · Current Opinion in Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 340

The role of CD8+ T‐cell replicative senescence in human aging

Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 336

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation☆

Spaulding, C., Guo, W., & Effros, R. B. (1999) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 258

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-α and IL-6 in C3B10RF1 mice

Spaulding, C. C., Walford, R. L., & Effros, R. B. (1997) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 224

CD28 Expression in T Cell Aging and Human Longevity

Boucher, N., Dufeu-Duchesne, T., Vicaut, E., Farge, D., Effros, R. B., & Schächter, F. (1998) · Experimental Gerontology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 194

Loss of CD28 expression on T lymphocytes: A marker of replicative senescence

Effros, R. B. (1997) · Developmental & Comparative Immunology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 175

Role of T lymphocyte replicative senescence in vaccine efficacy

Effros, R. B. (2007) · Vaccine

T-cell and B-cell ImmunologyTelomeres, Telomerase, and Senescence

Cited by 152

Telomere/telomerase dynamics within the human immune system: Effect of chronic infection and stress

Effros, R. B. (2011) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 137

Replicative senescence of CD8 T cells: Effect on human ageing

Effros, R. B. (2004) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 127

Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly

Effros, R. B. (1998) · The American Journal of Human Genetics

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 105

Insomnia and Telomere Length in Older Adults

Carroll, J. E., Esquivel, S., Goldberg, A., Seeman, T. E., Effros, R. B., Dock, J., Olmstead, R., Breen, E. C., & Irwin, M. R. (2016) · Sleep

Sleep and related disordersTelomeres, Telomerase, and Senescence

Cited by 85

Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes

Parish, S. T., Wu, J. E., & Effros, R. B. (2010) · Journal of Clinical Immunology

Telomeres, Telomerase, and SenescenceT-cell and B-cell Immunology

Cited by 85

Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes

Yang, O. O., Lin, H., Dagarag, M., Ng, H. L., Effros, R. B., & Uittenbogaart, C. H. (2005) · Virology

HIV Research and TreatmentTelomeres, Telomerase, and Senescence

Cited by 79

Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells

Chou, J. P., Ramirez, C. M., Wu, J. E., & Effros, R. B. (2013) · PLoS ONE

HIV Research and TreatmentHIV-related health complications and treatments

Cited by 78

The silent war of CMV in aging and HIV infection

Effros, R. B. (2016) · Mechanisms of Ageing and Development

Cytomegalovirus and herpesvirus researchTelomeres, Telomerase, and Senescence

Cited by 63

Kleemeier Award Lecture 2008 – the canary in the coal mine: telomeres and human healthspan

Effros, R. B. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 58