The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men
Abstract
OBJECTIVE: The incidence of anal cancer among homosexual men exceeds that of cervical cancer in women, and HIV-positive homosexual men may be at even higher risk than HIV-negative men. Cervical cancer is preceded by high-grade squamous intra-epithelial lesions (HSIL) and anal HSIL may similarly be the precursor to anal cancer. In this study, we describe the incidence of and risk factors for HSIL in HIV-positive and HIV-negative homosexual and bisexual men. DESIGN: Prospective cohort study of HIV-positive and HIV-negative homosexual men. SETTING: The University of California, San Francisco. PATIENTS: 346 HIV-positive and 262 HIV-negative men enrolled at baseline, 277 HIV-positive and 221 HIV-negative homosexual men followed after baseline. STUDY DESIGN: A questionnaire was administered detailing lifestyle habits, medical history and sexual practices. Anal swabs for cytology and human papillomavirus studies were obtained, followed by biopsies of visible lesions. Human papillomavirus testing was performed using polymerase chain reaction (PCR) and 'hybrid capture'. Blood was obtained for HIV testing and measurement of CD4 levels. MAIN OUTCOME MEASURES: Incident HSIL. RESULTS: HIV-positive men were more likely to develop HSIL than HIV-negative men relative risk (RR), 3.7; 95% confidence interval (CI), 2.6-5.7. Life-table estimates of the 4-year incidence of HSIL was 49% (95% CI, 41-56) among HIV-positive men and 17% (95% CI, 12-23) among HIV-negative men. Among HIV-positive men, those with lower baseline CD4 counts (P = 0.007) and persistent infection with one or more human papillomavirus types, determined using PCR (P = 0.0001), were more likely to develop HSIL. CONCLUSIONS: HIV infection, lower CD4 levels and human papillomavirus infection were associated with high rates of incident HSIL among homosexual men. However, high rates were found at all CD4 levels among HIV-positive men and among HIV-negative men.
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Cites
Sexual Practices, Sexually Transmitted Diseases, and the Incidence of Anal Cancer
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Moss, A. R., Bacchetti, P., Osmond, D., Krampf, W., Chaisson, R. E., Stites, D., Wilber, J., Allain, J.-P., & Carlson, J. (1988) · BMJ · doi:10.1136/bmj.296.6624.745 · Cited by 544
Anal Cytology as a Screening Tool for Anal Squamous Intraepithelial Lesions
Palefsky, J. M., Holly, E. A., Hogeboom, C. J., Berry, J. M., Jay, N., & Darragh, T. M. (1997) · Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology · doi:10.1097/00042560-199704150-00004 · Cited by 343
Self-citationColposcopic appearance of anal squamous intraepithelial lesions: Relationship to histopathology
Jay, N., Berry, M. J., Hogeboom, C. J., Holly, E. A., Darragh, T. M., & Palefsky, J. M. (1997) · Diseases of the Colon & Rectum · doi:10.1007/bf02051199 · Cited by 265
Self-citationWinkelstein, W. (1987) · JAMA · doi:10.1001/jama.1987.03390030051019 · Cited by 240
Detection of human papillomavirus DNA in anal intraepithelial neoplasia and anal cancer.
Palefsky, J. M., Holly, E. A., Gonzales, J., Berline, J. W., Ahn, D. K., & Greenspan, J. S. (1991) · PubMed · Cited by 220
Self-citationZaki, S. R., Judd, R. L., Coffield, L. M., Greer, P. W., Rolston, F., & Evatt, B. L. (1992) · PubMed · Cited by 111
Breese, P., Judson, F. N., Penley, K. A., & Douglas, J. M. (1995) · Sexually Transmitted Diseases · doi:10.1097/00007435-199501000-00002 · Cited by 102
Cited by
2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host
Rubin, L. G., Levin, M. J., Ljungman, P., Davies, E. G., Avery, R., Tomblyn, M., Bousvaros, A., Dhanireddy, S., Sung, L., Keyserling, H., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/cit684 · Cited by 1,613
Machalek, D. A., Poynten, M., Jin, F., Fairley, C. K., Farnsworth, A., Garland, S. M., Hillman, R. J., Petoumenos, K., Roberts, J., Tabrizi, S. N., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70080-3 · Cited by 963
Richel, O., de Vries, H. J., van Noesel, C. J., Dijkgraaf, M. G., & Prins, J. M. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70067-6 · Cited by 181
Tong, W. W. Y., Jin, F., McHugh, L. C., Maher, T., Sinclair, B., Grulich, A. E., Hillman, R. J., & Carr, A. (2013) · AIDS · doi:10.1097/qad.0b013e3283633111 · Cited by 112
Nassereddine, H., Charpentier, C., Bucau, M., Joly, V, Bienvenu, L., Davitian, C., Abramowitz, L., Benabderrahmane, D., Kotelevets, L., Chastre, E., et al. (2018) · HIV Medicine · doi:10.1111/hiv.12661 · Cited by 6
Metadata
- Authors
- Palefsky, J. M., Holly, E. A., Ralston, M. L., Jay, N., Berry, J. M., & Darragh, T. M.
- Venue
- AIDS
- Published
- 1998-03
- Volume
- 12
- Issue
- 5
- Pages
- 495-503
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2088909920
- Cited by
- 391
- References
- 8
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. https://app.cochat.ai/papers/10.1097/00002030-199805000-00011
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- Palefsky, J. M., Holly, E. A., Ralston, M. L., Jay, N., Berry, J. M., & Darragh, T. M. (1998). High incidence of anal high-grade squamous intra-epithelial lesions among HIV-positive and HIV-negative homosexual and bisexual men. AIDS. https://doi.org/10.1097/00002030-199805000-00011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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