The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up
Abstract
OBJECTIVE: To characterize the impact of intermittent use of triple drug antiretroviral therapy on survival. DESIGN, SETTING AND PARTICIPANTS: Population-based analysis of 1282 antiretroviral therapy naive HIV-positive individuals aged 18 years and older in British Columbia who started triple-combination therapy between August 1996 and December 1999. Therapy use was estimated by dividing the number of months of medications dispensed by the number of months of follow-up. Intermittent therapy was defined as the participant having obtained less than 75% of their medication in the first 12 months. MAIN OUTCOME MEASURE: Cumulative all-cause mortality rates from the start of triple drug antiretroviral therapy to 30 September 2000. RESULTS: As of 30 September 2000, 106 subjects had died. Cumulative mortality was 3.9% (+/- 0.5%) at 12 months. In a multivariate model, after controlling for other variables that were significant in the univariate analyses each 100 cell decrement in baseline CD4 cell count and the intermittent use of antiretroviral drugs were associated with increased mortality with risk ratios of 1.31 [95% confidence interval (CI), 1.16-1.49; P < 0.001] and 2.90 (95% CI, 1.93-4.36; P < 0.001), respectively. In order to control for downward drift, intermittent use of therapy was measured over the first year whereas other factors were measured at the end of year 1. After adjusting for all other factors, those participants who used antiretroviral drugs intermittently were 2.97 times (95% CI, 1.33-6.62; P = 0.008) more likely to die. CONCLUSION: Our study demonstrates that even after adjusting for other prognostic factors intermittent use of antiretroviral therapy was associated with increased mortality.
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Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma
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Self-citationIn vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
Condra, J. H., Schleif, W. A., Blahy, O. M., Gabryelski, L. J., Graham, D. J., Quintero, J., Rhodes, A., Robbins, H. L., Roth, E., Shivaprakash, M., et al. (1995) · Nature · doi:10.1038/374569a0 · Cited by 974
Non-adherence to highly active antiretroviral therapy predicts progression to AIDS
Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., & Moss, A. (2001) · AIDS · doi:10.1097/00002030-200106150-00015 · Cited by 960
Self-citationImproved Survival Among HIV-Infected Individuals Following Initiation of Antiretroviral Therapy
Hogg, R. S. (1998) · JAMA · doi:10.1001/jama.279.6.450 · Cited by 850
Self-citationMontaner, J. S. G., Reiss, P., Cooper, D., Vella, S., Harris, M., Conway, B., Wainberg, M. A., Smith, D., Robinson, P., Hall, D., et al. (1998) · JAMA · doi:10.1001/jama.279.12.930 · Cited by 756
Self-citationHogg, R. S. (2001) · JAMA · doi:10.1001/jama.286.20.2568 · Cited by 728
Self-citationCarpenter, C. C. J. (1997) · JAMA · doi:10.1001/jama.1997.03540480062040 · Cited by 725
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Pop-Eleches, C., Thirumurthy, H., Habyarimana, J. P., Zivin, J. G., Goldstein, M. P., de Walque, D., MacKeen, L., Haberer, J., Kimaiyo, S., Sidle, J., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834380c1 · Cited by 982
Self-citationBarriers to Antiretroviral Adherence for Patients Living with HIV Infection and AIDS in Botswana
Weiser, S., Wolfe, W., Bangsberg, D., Thior, I., Gilbert, P., Makhema, J., Kebaabetswe, P., Dickenson, D., Mompati, K., Essex, M., et al. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200311010-00004 · Cited by 473
Self-citationMeasuring Adherence to Antiretroviral Therapy in a Diverse Population Using a Visual Analogue Scale
Giordano, T. P., Guzman, D., Clark, R., Charlebois, E. D., & Bangsberg, D. R. (2004) · HIV Clinical Trials · doi:10.1310/jfxh-g3x2-eym6-d6ug · Cited by 337
Self-citationFood Insecurity as a Barrier to Sustained Antiretroviral Therapy Adherence in Uganda
Weiser, S. D., Tuller, D. M., Frongillo, E. A., Senkungu, J., Mukiibi, N., & Bangsberg, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010340 · Cited by 321
Self-citationOyugi, J. H., Byakika-Tusiime, J., Charlebois, E. D., Kityo, C., Mugerwa, R., Mugyenyi, P., & Bangsberg, D. R. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200408150-00014 · Cited by 282
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Metadata
- Authors
- Hogg, R. S., Heath, K., Bangsberg, D., Yip, B., Press, N., O'Shaughnessy, M. V., & Montaner, J. S. G.
- Venue
- AIDS
- Published
- 2002-05
- Volume
- 16
- Issue
- 7
- Pages
- 1051-1058
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2156330207
- Cited by
- 425
- References
- 29
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hogg, R. S., Heath, K., Bangsberg, D., Yip, B., Press, N., O'Shaughnessy, M. V., & Montaner, J. S. G. (2002). Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up. AIDS. https://doi.org/10.1097/00002030-200205030-00012
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