The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Multiple Validated Measures of Adherence Indicate High Levels of Adherence to Generic HIV Antiretroviral Therapy in a Resource-Limited Setting
Abstract
BACKGROUND: There are no validated measures of adherence to HIV antiretroviral therapy in resource-poor settings. Such measures are essential to understand the unique barriers to adherence as access to HIV antiretroviral therapy expands. METHODS: We assessed correspondence between multiple measures of adherence and viral load suppression in 34 patients purchasing generic Triomune antiretroviral therapy (coformulated stavudine, lamivudine, and nevirapine; CIPLA, Ltd., Mumbai, India) in Kampala, Uganda. Measures included 3-day patient self-report, 30-day visual analog scale, electronic medication monitoring, and unannounced home pill count. HIV-1 load was determined at baseline and 12 weeks. RESULTS: Mean adherence was 91%-94% by all measures. Seventy-six percent of subjects had a viral load of <400 copies/mL at 12 weeks. All measures were closely correlated with each other (R = 0.77-0.89). Each measure was also significantly associated with 12-week HIV load. There was no significant difference between patient-reported and objective measures of adherence. CONCLUSIONS: This sample of patients purchasing generic HIV antiretroviral therapy has among the highest measured adherence reported to date. Patient-reported measures were closely associated with objective measures. The relative ease of administration of the 30-day visual analog scale suggests that this may be the preferred method to assess adherence in resource-poor settings.
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Cites
Adherence to Protease Inhibitor Therapy and Outcomes in Patients with HIV Infection
Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., Wagener, M. M., & Singh, N. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-1-200007040-00004 · Cited by 3,289
Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., & PATIENT CARE COMMITTEE & ADHERENCE (2000) · AIDS Care · doi:10.1080/09540120050042891 · Cited by 1,428
Bangsberg, D. R., Hecht, F. M., Charlebois, E. D., Zolopa, A. R., Holodniy, M., Sheiner, L., Bamberger, J. D., Chesney, M. A., & Moss, A. (2000) · AIDS · doi:10.1097/00002030-200003100-00008 · Cited by 1,033
Self-citationNon-adherence to highly active antiretroviral therapy predicts progression to AIDS
Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., & Moss, A. (2001) · AIDS · doi:10.1097/00002030-200106150-00015 · Cited by 960
Self-citationA Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
Liu, H., Golin, C. E., Miller, L. G., Hays, R. D., Beck, C. K., Sanandaji, S., Christian, J., Maldonado, T., Duran, D., Kaplan, A. H., et al. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-10-200105150-00011 · Cited by 758
Arnsten, J. H., Demas, P. A., Farzadegan, H., Grant, R. W., Gourevitch, M. N., Chang, C., Buono, D., Eckholdt, H., Howard, A. A., & Schoenbaum, E. E. (2001) · Clinical Infectious Diseases · doi:10.1086/323201 · Cited by 637
Gifford, A. L., Bormann, J. E., Shively, M. J., Wright, B. C., Richman, D. D., & Bozzette, S. A. (2000) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200004150-00005 · Cited by 460
Walsh, J. C., Mandalia, S., & Gazzard, B. G. (2002) · AIDS · doi:10.1097/00002030-200201250-00017 · Cited by 443
Impact of Adherence and Highly Active Antiretroviral Therapy on Survival in HIV-Infected Patients
de Olalla, P. G., Knobel, H., Carmona, A., Guelar, A., López-Colomés, J. L., & Caylà, J. A. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00042560-200205010-00014 · Cited by 430
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Cited by
Lester, R. T., Ritvo, P., Mills, E. J., Kariri, A., Karanja, S., Chung, M. H., Jack, W., Habyarimana, J., Sadatsafavi, M., Najafzadeh, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61997-6 · Cited by 1,278
Pop-Eleches, C., Thirumurthy, H., Habyarimana, J. P., Zivin, J. G., Goldstein, M. P., de Walque, D., MacKeen, L., Haberer, J., Kimaiyo, S., Sidle, J., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834380c1 · Cited by 982
“The level of adherencewe observed was less than what has been seen in early reports using electronic monitoring [39].”
ResultSelf-citationExplaining Adherence Success in Sub-Saharan Africa: An Ethnographic Study
Ware, N. C., Idoko, J., Kaaya, S., Biraro, I. A., Wyatt, M. A., Agbaji, O., Chalamilla, G., & Bangsberg, D. R. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000011 · Cited by 437
Self-citationFinitsis, D. J., Pellowski, J. A., & Johnson, B. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088166 · Cited by 355
Johnson, M. O., Neilands, T. B., Dilworth, S. E., Morin, S. F., Remien, R. H., & Chesney, M. A. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9118-3 · Cited by 352
Metadata
- Authors
- Oyugi, J. H., Byakika-Tusiime, J., Charlebois, E. D., Kityo, C., Mugerwa, R., Mugyenyi, P., & Bangsberg, D. R.
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2004-08
- Volume
- 36
- Issue
- 5
- Pages
- 1100-1102
- ISSN
- 1525-4135 (ISSN-L)
- OpenAlex
- W1982799563
- Cited by
- 282
- References
- 17
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oyugi, J. H., Byakika-Tusiime, J., Charlebois, E. D., Kityo, C., Mugerwa, R., Mugyenyi, P., & Bangsberg, D. R. (2004). Multiple Validated Measures of Adherence Indicate High Levels of Adherence to Generic HIV Antiretroviral Therapy in a Resource-Limited Setting. JAIDS Journal of Acquired Immune Deficiency Syndromes. https://doi.org/10.1097/00126334-200408150-00014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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